Significance of preoperative butyrylcholinesterase as an independent predictor of biochemical recurrence-free survival in patients with prostate cancer treated with radical prostatectomy

Koie, Takuya; Οhyama, Chikara; Hatakeyama, Shingo; Imai, Atsushi; Yoneyama, Takahiro; Hashimoto, Yasuhiro; Yoneyama, T.; Tobisawa, Yuki; Hosogoe, Shogo; Yamamoto, Hayato; Kitayama, Masato; Hirota, Kazuyoshi

doi:10.1007/s10147-015-0880-x

Cited by 19 publications

(21 citation statements)

References 23 publications

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“…Patient demographics are shown in Table 3. Staging and grading information regarding the tumors and patient follow-up have been described previously [35]. In brief, PSA recurrence after RP was defined by two consecutive PSA values of >0.2 ng/mL with a 1-month interval and after a postoperative decrease below the detection limit (<0.001 ng/mL).…”

Section: Methodsmentioning

confidence: 99%

Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer

Hagiwara

Tobisawa

Kaya

et al. 2017

IJMS

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Wisteria floribunda agglutinin (WFA) preferably binds to LacdiNAc glycans, and its reactivity is associated with tumor progression. The aim of this study to examine whether the serum LacdiNAc carrying prostate-specific antigen–glycosylation isomer (PSA-Gi) and WFA-reactivity of tumor tissue can be applied as a diagnostic and prognostic marker of prostate cancer (PCa). Between 2007 and 2016, serum PSA-Gi levels before prostate biopsy (Pbx) were measured in 184 biopsy-proven benign prostatic hyperplasia patients and 244 PCa patients using an automated lectin-antibody immunoassay. WFA-reactivity on tumor was analyzed in 260 radical prostatectomy (RP) patients. Diagnostic and prognostic performance of serum PSA-Gi was evaluated using area under the receiver-operator characteristic curve (AUC). Prognostic performance of WFA-reactivity on tumor was evaluated via Cox proportional hazards regression analysis and nomogram. The AUC of serum PSA-Gi detecting PCa and predicting Pbx Grade Group (GG) 3 and GG ≥ 3 after RP was much higher than those of conventional PSA. Multivariate analysis showed that WFA-reactivity on prostate tumor was an independent risk factor of PSA recurrence. The nomogram was a strong model for predicting PSA-free survival provability with a c-index ≥0.7. Serum PSA-Gi levels and WFA-reactivity on prostate tumor may be a novel diagnostic and pre- and post-operative prognostic biomarkers of PCa, respectively.

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Section: Methodsmentioning

confidence: 99%

Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer

Hagiwara

Tobisawa

Kaya

et al. 2017

IJMS

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“…Serum levels of BChE has been found to decrease during inflammation. Koie et al [54] in a retrospective study reviewed the pathological records of 535 PC patients submitted to RP. The cut-off point for the serum BChE level was determined as 168 IU/L according to previously described methods.…”

Section: Prognostic Value Of Inflammation In Prostate Cancer Submittementioning

confidence: 99%

“…As of now, the studies are mainly retrospective, but some findings may suggest that the grade of inflammation in preoperative biopsy specimens could be used to risk-stratify men with PC for risk of biochemical progression after RP [54, 55]. However, in a multivariate analysis after adjustment with the other clinical parameters (PSA, clinical stage, Gleason score), inflammation did not result an independent predictor.…”

Section: Prognostic Value Of Inflammation In Prostate Cancer Submittementioning

confidence: 99%

Prognostic value of inflammation in prostate cancer progression and response to therapeutic: a critical review

et al. 2016

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Prostate is an immune-competent organ normally populated by inflammatory cells. Prostatic inflammation origin can be multi-factorial and there are some emerging evidences on its possible role as a factor involved in prostate cancer (PC) pathogenesis and progression.This review critically analyzes the role of inflammation as a prognostic factor for progression and aggressiveness of PC. We verified the last 10 years literature data on the association between inflammation and PC aggressiveness, or PC response to therapies.Several studies tried to correlate different inflammatory factors with the aggressiveness and metastatization of PC; all data sustain the role of inflammation in PC progression but they also produce confusion to identify a reliable clinical prognostic marker.Data on patients submitted to radical prostatectomy (RP) showed that cases with marked intraprostatic tissue inflammation are associated with higher rate of biochemical progression; systemic inflammation markers appear to have a significant prognostic value.Analyzing data on patients submitted to radiotherapy (RT) emerges a significant association between high neuthrophil to lymphocyte ratio (NLR) and decreased progression free survival and overall survival; also plateled to lymphocyte ratio (PLR) and C-reactive protein (CRP) have been proposed as significant prognostic factors for progression and overall survival.In patients submitted to androgen deprivation therapy (ADT), inflammation may drive castration resistant PC (CRPC) development by activation of STAT3 in PC cells. NLR has been proposed as independent predictor of overall survival in CRPC submitted to chemotherapy.Most of data are focused on markers related to systemic inflammation such as NLR and CRP, more than specifically to chronic prostatic inflammation. The suggestion is that these inflammatory parameters, also if not specific for prostatic inflammation and possibly influenced by several factors other than PC, can integrate with established prognostic factors.

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“…A study including 108 academic and community practices throughout Japan found that preoperative serum PSA levels and Gleason scores were higher in a Japanese cohort compared with those in an American cohort . Similarly, several previous reports of Japanese cohorts have reported poorer prognosis after RP compared with North American or European cohorts . It has been reported that the rate of PSA screening in Japan is much lower than that in European counties .…”

Section: Introductionmentioning

confidence: 96%

Prostate‐specific antigen screening impacts on biochemical recurrence in patients with clinically localized prostate cancer

et al. 2018

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Significance of preoperative butyrylcholinesterase as an independent predictor of biochemical recurrence-free survival in patients with prostate cancer treated with radical prostatectomy

Abstract: This study validated preoperative serum BChE levels as an independent prognostic factor for PCa after RP.

Cited by 19 publications

References 23 publications

Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer

Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer

Prognostic value of inflammation in prostate cancer progression and response to therapeutic: a critical review

Prostate‐specific antigen screening impacts on biochemical recurrence in patients with clinically localized prostate cancer

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