Significance of protein kinase C in the neuropsychotoxicity induced by methamphetamine-like psychostimulants

Shin, Eun Joo; Dang, Duy Khanh; Hwang, Young Gwang; Tran, Hai Quyen; Sharma, Naveen; Jeong, Ji Hoon; Jang, Choon‐Gon; Nah, Seung Yeol; Nabeshima, Toshitaka; Yoneda, Yukio; Cadet, Jean Lud; Kim, Hyoung Chun

doi:10.1016/j.neuint.2019.01.014

Cited by 20 publications

(9 citation statements)

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“…The dorsal striatum is a brain region that is integral to various behavioral changes consequent to drug taking behaviors including habit forming and drug seeking during periods of opioid withdrawal 19,22,23,59 . Similar to other observations with cocaine, methamphetamine, and other drugs 58,[60][61][62][63][64][65][66] , we found increased phosphorylation of PKC, ERK1/2, MSK1/2, and pCREB in the rat dorsal striatum after repeated exposure to oxycodone SA. Increased phosphorylation of H3S10pK14Ac, a marker that is downstream of these kinases 34,37,67 is of interest because these findings suggest that repeated exposure to long-access oxycodone self-administration might engender a permissive molecular state characterized by increased histone H3 phosphoacetylation and a more open chromatin structure.…”

Section: Discussionsupporting

confidence: 90%

Oxycodone self-administration activates the mitogen-activated protein kinase/ mitogen- and stress-activated protein kinase (MAPK-MSK) signaling pathway in the rat dorsal striatum

Blackwood¹,

McCoy²,

Ladenheim³

et al. 2021

Sci Rep

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To identify signaling pathways activated by oxycodone self-administration (SA), Sprague–Dawley rats self-administered oxycodone for 20 days using short—(ShA, 3 h) and long-access (LgA, 9 h) paradigms. Animals were euthanized 2 h after SA cessation and dorsal striata were used in post-mortem molecular analyses. LgA rats escalated their oxycodone intake and separated into lower (LgA-L) or higher (LgA-H) oxycodone takers. LgA-H rats showed increased striatal protein phosphorylation of ERK1/2 and MSK1/2. Histone H3, phosphorylated at serine 10 and acetylated at lysine 14 (H3S10pK14Ac), a MSK1/2 target, showed increased abundance only in LgA-H rats. RT-qPCR analyses revealed increased AMPA receptor subunits, GluA2 and GluA3 mRNAs, in the LgA-H rats. GluA3, but not GluA2, mRNA expression correlated positively with changes in pMSK1/2 and H3S10pK14Ac. These findings suggest that escalated oxycodone SA results in MSK1/2-dependent histone phosphorylation and increases in striatal gene expression. These observations offer potential avenues for interventions against oxycodone addiction.

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Section: Discussionsupporting

confidence: 90%

Oxycodone self-administration activates the mitogen-activated protein kinase/ mitogen- and stress-activated protein kinase (MAPK-MSK) signaling pathway in the rat dorsal striatum

Blackwood¹,

McCoy²,

Ladenheim³

et al. 2021

Sci Rep

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“…However, dopamine is also an important object that cannot be ignored. We especially emphasized the role of PKC in the MA-induced hypertensive effect while the PKC has been found to mediate phosphorylation of the dopamine transporter and subsequently regulate synaptic dopamine release [44]. Furthermore, ionotropic glutamate receptors and mGluRs are close to each other in the postsynaptic membrane [45] and may crosstalk to each other to shape their output information [46].…”

Section: Discussionmentioning

confidence: 99%

Activation of mGluR5 and NMDA Receptor Pathways in the Rostral Ventrolateral Medulla as a Central Mechanism for Methamphetamine-Induced Pressor Effect in Rats

et al. 2020

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Acute hypertension produced by methamphetamine (MA) is well known, mainly by the enhancement of catecholamine release from sympathetic terminals. However, the central pressor mechanism of the blood-brain-barrier-penetrating molecule remains unclear. We used radio-telemetry and femoral artery cannulation to monitor the mean arterial pressure (MAP) in conscious free-moving and urethane-anesthetized rats, respectively. Expression of Fos protein (Fos) and phosphorylation of N-methyl-D-aspartate receptor subunit GluN1 in the rostral ventrolateral medulla (RVLM) were detected using Western blot analysis. ELISA was carried out for detection of protein kinase C (PKC) activity in the RVLM. MA-induced glutamate release in the RVLM was assayed using in vivo microdialysis and HPLC. Systemic or intracerebroventricular (i.c.v.) administration of MA augments the MAP and increases Fos expression, PKC activity, and phosphorylated GluN1-ser 896 (pGluN1-ser 896) in the RVLM. However, direct microinjection of MA into the RVLM did not change the MAP. Unilateral microinjection of a PKC inhibitor or a metabotropic glutamate receptor 5 (mGluR5) antagonist into the RVLM dose-dependently attenuated the i.c.v. MA-induced increase in MAP and pGluN1-ser 896. Our data suggested that MA may give rise to glutamate release in the RVLM further to the activation of mGluR5-PKC pathways, which would serve as a central mechanism for the MA-induced pressor effect.

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“…Oxidative stress can disrupt intracellular reduction-oxidation (redox) levels, which in turn inhibits/activates several signaling molecules and signaling pathways, such as the Kelch-like ECH-associated protein 1 (Keap1)/Nrf2 signaling pathway [ 41 , 42 , 43 , 44 ], the NF-κB signaling pathway (a key regulator of protein synthesis) [ 45 , 46 ], brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling channel [ 47 ], the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway [ 48 ], protein kinase C [ 49 , 50 ], MAPKs [ 51 , 52 ], adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK), etc. These signaling molecules ultimately regulate the expression of relevant redox-related target genes to regulate redox levels.…”

Section: Oxidative Stress Signal Pathwaysmentioning

confidence: 99%

Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs

Hao

Xing

2021

Animals

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Oxidative stress refers to the dramatic increase in the production of free radicals in human and animal bodies or the decrease in the ability to scavenging free radicals, thus breaking the antioxidation–oxidation balance. Various factors can induce oxidative stress in pig production. Oxidative stress has an important effect on pig performance and healthy growth, and has become one of the important factors restricting pig production. Based on the overview of the generation of oxidative stress, its effects on pigs, and signal transduction pathways, this paper discussed the nutritional measures to alleviate oxidative stress in pigs, in order to provide ideas for the nutritional research of anti-oxidative stress in pigs.

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Significance of protein kinase C in the neuropsychotoxicity induced by methamphetamine-like psychostimulants

Cited by 20 publications

References 124 publications

Oxycodone self-administration activates the mitogen-activated protein kinase/ mitogen- and stress-activated protein kinase (MAPK-MSK) signaling pathway in the rat dorsal striatum

Oxycodone self-administration activates the mitogen-activated protein kinase/ mitogen- and stress-activated protein kinase (MAPK-MSK) signaling pathway in the rat dorsal striatum

Activation of mGluR5 and NMDA Receptor Pathways in the Rostral Ventrolateral Medulla as a Central Mechanism for Methamphetamine-Induced Pressor Effect in Rats

Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs

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