Significance of serological monitoring in a Bombay Rh (D) negative phenotype pregnant woman: A case report

Jain, Ashish; Kumawat, Vijay; Patil, Sandeep; Kumar, Prateek; Marwaha, Neelam; Sharma, Ratti Ram

doi:10.1016/j.transci.2012.06.026

Cited by 8 publications

(16 citation statements)

References 6 publications

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“…The patient had potent high titre anti-H antibodies and the author expected the newborns to suffer from HDN which did not occur, probably due to weak expression of H antigen on infant's RBC. A similar observation was made by Jain et al [15] at our institute.…”

Section: Discussionsupporting

confidence: 91%

Acute Hemolytic Transfusion Reaction in a Patient with Bombay Phenotype: Implications for ABO Grouping

Malhotra

Dhawan²,

Jain³

et al. 2013

Indian J Hematol Blood Transfus

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Section: Discussionsupporting

confidence: 91%

Acute Hemolytic Transfusion Reaction in a Patient with Bombay Phenotype: Implications for ABO Grouping

Malhotra

Dhawan²,

Jain³

et al. 2013

Indian J Hematol Blood Transfus

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“…The Bombay blood group is one of the oldest and unique blood groups that has ever existed [1]. It was first discovered and described in India by Dr Bhende and colleagues about five decades ago [2].…”

Section: Introductionmentioning

confidence: 99%

“…It is a rare blood group that lacks the unique antigen known as the H antigen or the OH group on the surface of erythrocytes of individuals. Its occurrence is estimated to be about 1 in 7600 individuals in the general population, 1 in 10,000 and 1:100, 000 in the Indian community and Europe, respectively [1,[3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical relevance of the Bombay or the OH phenotype lies in the ability to cause haemolytic disease of the foetus and the newborn (HDFN) with its attendant consequences as the antibodies cross the placenta into the foetal circulation [1,6,7]. It is unclear, but has been noted that the OH phenotype can result in blood transfusion reaction if individuals with the Bombay blood group receive blood from other groups [3,[8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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The Bombay Blood Group: How Rare is It? A Case Report and a Review of the Literature

Ekanem

Poozhikalayil

Sinha

2020

JAMMR

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The Bombay blood group is a rare type of blood group which is very distinct from the ABO system and was first discovered in India about five decades ago. This blood group describes individuals who lack the H antigen and thus present with the anti H antibodies in addition to anti A and anti B antibodies. Bombay blood group is sometimes mistaken for blood group O. The significance of this blood group is in its ability to potentially cause fatal blood transfusion reaction and haemolytic disease of the foetus and the neonate. Aim: This case report aims to elucidate the rare occurrence of the Bombay blood group. Methods: We describe a case report of the pregnancy, labour and delivery of a multiparous Indian woman with the Bombay blood group in her second pregnancy. Results: The index case had an uneventful pregnancy, labour and delivery without the need for blood transfusion. The neonate was Rhesus D positive and did not have any complications. Conclusion: Bombay blood group is a rare blood group which can lead to blood transfusion reactions and haemolytic disease of the foetus and newborn. Pregnancy, labour and delivery should be managed in a unit with the availability of anti H blood to avoid foetal and maternal complications.

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“…Furthermore, Bcl-2 is unique in that it inhibits apoptosis rather than promoting cell proliferation. Multiple genes have been identified within the Bcl-2 family; some of these genes, such as Bcl-xs, Bax and Bak, drive the death mechanism and others, such as Bcl-2 and Bcl-xl, act against apoptotic cell death ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative Effect of Recombinant Shiga Toxin in Induction of Pro- and Anti-Apoptotic Markers and Inflammatory Cytokines in Epithelial and Monocytic Cells

Jafari

Oloomi

Bouzari

2016

Jundishapur J Microbiol

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Background:Shiga toxins (Stxs, also referred to as verotoxins) are a family of bacterial protein toxins generated by Stx producing-Escherichia coli (STEC), such as E. coli serotype O157:H7.Objectives:The aim of this study was to investigate the effect of recombinant and native Shiga toxin (Stx) in induction of pro- and anti-apoptosis factors and stimulation of immune response to HeLa and THP-1 cells.Materials and Methods:The HeLa and THP-1 cells were used to study the effect of native and recombinant Shiga toxin. For this purpose, 106 cells were cultured overnight in six-well plates and different concentrations of Stx were added to each well. The cells were then collected after 24 hours of incubation. Total RNA and protein was extracted. Firstly, the total RNA was used in reverse transcription-polymerase chain reaction (RT-PCR) for detection of interleukin (IL)-1α, IL-1β, IL-8, tumor necrosis factor (TNF)-α, B-cell lymphoma (Bcl)-2 and Bcl-xl transcript. Protein expression of pro- and anti-apoptotic factors was also confirmed by western blot analysis.Results:The IL-1α and IL-8 were increased by recombinant and native Stx. Interleukin-1β was detected in THP-1, while TNF-α was detected HeLa cells. Furthermore, Bcl-2 and Bcl-xl expression was observed in HeLa cells. However, expression of Bak was reduced by recombinant Stx and native toxin at the protein level, while Bcl-xl expression was increased.Conclusions:These results suggest that toxins induce inflammatory responses, particularly through expression of chemokine. Recombinant Stx and native toxin induced apoptosis by balancing between different pro- and anti-apoptotic Bcl-2 family-factors in epithelial cells. In this study, for the first time, recombinant and native Stx induction of apoptotic factors and stimulation of immune response to HeLa and THP-1 cells were compared.

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Significance of serological monitoring in a Bombay Rh (D) negative phenotype pregnant woman: A case report

Cited by 8 publications

References 6 publications

Acute Hemolytic Transfusion Reaction in a Patient with Bombay Phenotype: Implications for ABO Grouping

Acute Hemolytic Transfusion Reaction in a Patient with Bombay Phenotype: Implications for ABO Grouping

The Bombay Blood Group: How Rare is It? A Case Report and a Review of the Literature

Comparative Effect of Recombinant Shiga Toxin in Induction of Pro- and Anti-Apoptotic Markers and Inflammatory Cytokines in Epithelial and Monocytic Cells

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