Significance of Serum Vitamin D Level in Tuberculosis Patients

Khan, Salauddin; Khan, Nafees A.; Shameem, Mohammad; Bhargva, Rakesh; Khan, Irfan; Anand, Nithin

doi:10.7860/jcdr/2018/28226.11781

Cited by 3 publications

(5 citation statements)

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“…A total of 24 studies, 1,21–27,29–33,45–47,52–54,56–60 3295 tuberculosis patients and 18 080 healthy controls were included in the meta-analysis of comparing the blood 25-hydroxyvitamin D concentration of the tuberculosis patients with that of the healthy controls (Fig. 3).…”

Section: Resultsmentioning

confidence: 99%

“…Among the 47 studies, seven studies reported the vitamin A status, two studies reported the vitamin C status, 33 studies reported the vitamin D status or the number of people with VDD, and five studies reported the vitamin E status in the tuberculosis group versus the control group. The 47 included studies included 32 case-control studies, 1,15,21,[24][25][26]28,[31][32][33][34][45][46][47][48][49][50][51][52][53] seven cross-sectional studies, 21,22,27,29,30,54,55 and eight cohort or nested case-control studies. 16,35,[56][57][58][59][60][61] The study characteristics are shown in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Associating the blood vitamin A, C, D and E status with tuberculosis: a systematic review and meta-analysis of observational studies

Fei

Wang

et al. 2022

Food Funct.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Associating the blood vitamin A, C, D and E status with tuberculosis: a systematic review and meta-analysis of observational studies

Fei

Wang

et al. 2022

Food Funct.

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“…Most studies performed to evaluate vitamin D levels in TB included only pulmonary TB. Very few studies in the recent past have included both pulmonary TB and extrapulmonary TB [13][14][15][16]. Hammami, F. et al, in their study, included only patients with extrapulmonary TB [17], and Pareek et al predominantly studied vitamin D deficiency in extrapulmonary TB [18].…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, among the 29 extrapulmonary TB patients, the most prevalent cases were observed in TB of spine-13 (44.83%) followed by pleural TB-7 (24.14%), TB lymph node-3 (10.34%), disseminated TB-2 (6.89%), CNS TB-2 (6.89%), TB abdomen -1 (3.45%), and TB salpingitis-1 (3.45%). In a few studies, TB pleural effusion was the predominant site of extrapulmonary TB [13,14,16,19]. In other studies, the TB lymph node was the predominant site of extrapulmonary TB [15,17,18].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Mamadapur,

Nagaraju,

Prabhu

2024

Medicina

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Background and Objectives: Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis, a member of the Mycobacterium tuberculosis complex. It contributes to significant morbidity and mortality. Treatment of TB poses a considerable challenge because of emerging drug resistance and the longer duration of therapy. Various past studies, both in vitro and in vivo, have established the role of vitamin D in the pathogenesis and treatment of TB. Results of in vivo studies are inconsistent, and this study aims to determine vitamin D levels and their association with newly diagnosed TB (pulmonary and extrapulmonary) cases and normal populations. Material and Methods: A Prospective Case-Control study with 116 subjects (58 cases and 58 controls) was conducted over two years. 29 cases of pulmonary TB and 29 cases of extrapulmonary TB constituted 58 cases of TB. Vitamin D levels were measured and compared in both the cases and controls. Data analysis was carried out using SPSS software 22.0. Results: The prevalence of vitamin D deficiency was 68.96% in the cases, while it was 51.72% in the controls. The reported median and quartile of serum vitamin D levels were 14.35 ng/mL (8.65, 25.48) in the TB group and 19.08 ng/mL (13.92, 26.17) in the control group. There was a significant statistical difference between the TB and non-TB populations with a p-value of 0.029 on the Mann–Whitney test. Conclusion: Vitamin D deficiency was more prevalent in individuals with TB than those without TB.

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“…Twenty-one studies [20][21][22][23][24][25]27,[30][31][32][33][35][36]41] showed a significant association between the presence of active TB and vitamin D deficiency (VDD), i.e. VDD was found in active TB patients.…”

Section: Outcomes Of the Included Studiesmentioning

confidence: 99%

Association of Vitamin D Deficiency With Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis

Kafle¹,

Basnet²,

Karki³

et al. 2021

Cureus

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Pulmonary tuberculosis, caused by Mycobacterium tuberculosis, is a significant public health issue, especially in developing countries, affecting millions of people every year. Despite the development of many antitubercular antibiotics and increased awareness of preventive methods, it is still a major cause of mortality worldwide. Vitamin D, a micronutrient known to have a major role in bone and calcium metabolism, has also shown its immunomodulatory effects to suppress mycobacterial growth. We conducted a systematic review and meta-analysis of the available evidence to explore the association between vitamin D levels and tuberculosis. We performed a systematic search for articles from inception to May 2021 in multiple databases. We included 26 studies in our qualitative synthesis and 12 studies in meta-analysis or quantitative synthesis. In our meta-analysis, we used a random-effect model to calculate the odds ratio (OR) of vitamin D deficiency in tuberculosis patients compared to the healthy controls. On pooled analysis, we found that the odds of the participants having vitamin D deficiency was 3.23 times more in tuberculosis patients compared to the healthy group (OR=3.23, CI = 1.91-5.45, p<0.0001). Thus, we concluded that there is an association between low levels of vitamin D and tuberculosis infections. We suggest conducting longterm prospective cohort studies in tuberculosis endemic countries to better understand the causal relationship between vitamin D deficiency and tuberculosis.

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Significance of Serum Vitamin D Level in Tuberculosis Patients

Cited by 3 publications

References 0 publications

Associating the blood vitamin A, C, D and E status with tuberculosis: a systematic review and meta-analysis of observational studies

Associating the blood vitamin A, C, D and E status with tuberculosis: a systematic review and meta-analysis of observational studies

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Association of Vitamin D Deficiency With Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis

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