Significance of stromal desmoplasia and myofibroblast appearance at the invasive front in squamous cell carcinoma of the oral cavity

Abstract

Fibrous stroma in SCC appeared to have a desmoplastic response. However, an independent invasive mechanism may regulate the stroma, with tumor desmoplasia occurring in highly developed, invasive tumors.

Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival

“…The findings in our study, which showed a statistically significant association between the frequency of myofibroblast appearance and poorer survival rates, are in accordance with prior reports 20,[24][25][26] . On the other hand, some authors did not find a significant association between myofibroblasts and patients survival 17 .…”

“…On the contrary, Vered et al 24 observed that abundance of SMF had an independent adverse effect on local control. In our study, lymph node metastases and regional recurrence occurred more frequently in the abundant myofibroblast group, which was also demonstrated by the findings of other authors 17,26 . However, this is the first study addressing its proliferation regarding occurrence of occult neck disease.…”

Comparison of Myofibroblasts Expression in Oral Squamous Cell Carcinoma, Verrucous Carcinoma, High Risk Epithelial Dysplasia, Low Risk Epithelial Dysplasia and Normal Oral Mucosa

“…In this study, myofibroblast expression was not observed in NOM, which is similar to the findings of Etemad-Moghadam et al [26]. The a-SMA expression was significantly [25]. Thus, results of this study support the Marsh et al [28] hypothesis that myofibroblast expression can be used in predicting the prognosis and deciding the treatment modalities.…”

“…Various studies reported the presence of stromal myofibroblasts in invasive breast, throat, and larynx cancers [21][22][23]. Recently, several studies [24][25][26][27][28] have investigated myofibroblast expression in oral squamous cell carcinoma (OSCC) and few studies [26,27] have investigated myofibroblast expression in oral premalignant lesions (oral epithelial dysplasia). The aim of this investigation was to assess the possible association between the presence of myofibroblasts and disease progression in the oral mucosa from premalignant conditions, to verrucous carcinoma to invasive squamous cell carcinoma.…”

Fibroblast-activation protein: a single marker that confidently differentiates morpheaform/infiltrative basal cell carcinoma from desmoplastic trichoepithelioma

“…[40][41][42][43][44] In contrast, in the skin, the desmoplastic stromal response may be observed in malignant and benign tumors. 3,4,[45][46][47][48][49][50][51][52] Given this, the obvious question is whether desmoplasia associated with a benign neoplasm is any different from that associated with malignant tumors.…”