Fibrous stroma in SCC appeared to have a desmoplastic response. However, an independent invasive mechanism may regulate the stroma, with tumor desmoplasia occurring in highly developed, invasive tumors.

This study concludes that bFGF and FGFR-1 expressions in fibroblasts at the invasive front are linked to the mode of invasion and the prognosis in OSCC.

[1] Petrological studies have suggested that oceanic crust is formed during the initial stage of subduction. However, there is little geophysical evidence for the formation of oceanic crust in the fore-arc region. We conducted an active-source seismic survey in the fore-arc region of the Izu-Bonin intraoceanic arc to examine processes of crustal formation associated with the initiation of subduction. We used seismic refraction tomography to obtain a detailed seismic velocity model and diffraction-stack migration of picked reflection travel times to derive reflectivity images. These data show a remarkably thin crust (<10 km thick) along the northern half of the Bonin ridge and abrupt crustal thickening (to ∼20 km) toward the south of the ridge. Comparison of velocity-depth profiles of the thin fore-arc crust of the Bonin ridge with those of typical oceanic crusts showed them to be seismologically identical. Boninitic magmatism is evident in the area of thin crust and tholeiitic-calcalkaline andesitic volcanism in the area of thick crust. High-precision dating of the volcanic rocks showed that the thin fore-arc oceanic crust was created soon after initiation of subduction (48-45 Ma) and that the nonoceanic thick crust was created with tholeiitic-calcalkaline andesitic magmatism after the boninitic magmatism was ceased. Our seismological image strongly supports the view that fore-arc oceanic crust was formed by fore-arc spreading during the initial stage of subduction along the Izu-Bonin intraoceanic arc.Citation: Kodaira, S., N. Noguchi, N. Takahashi, O. Ishizuka, and Y. Kaneda (2010), Evolution from fore-arc oceanic crust to island arc crust: A seismic study along the Izu-Bonin fore arc,

We suggest that it is important to investigate the expression of p53 and PCNA at the invasive front of OSCC.

No abstract