Significance of tenascin serum level as tumor marker in primary colorectal carcinoma

Riedl, S; Bodenmüller, Heinz; Hinz, Ulf; Holle, Rolf; Möller, Peter; Schlag, Peter M.; Herfarth, Christian; Faissner, Andréas

doi:10.1002/ijc.2910640113

Cited by 36 publications

(29 citation statements)

References 19 publications

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“…This finding has been described by others in colorectal cancer (Sugawara et al, 1991;Riedel et al, 1992Riedel et al, , 1995Sakai et al, 1993;Hauptmann et al, 1995) and in several other tumour types (Natali and Zardi, 1989;Ibrahim et al, 1993;Moch et al, 1993;Shoji et al, 1993;Ikeda et al, 1995;Ilunga and Iriyama, 1995;Yoshida et al, 1995). Like Sugawara et al (1991), we also found two different staining patterns.…”

Section: Discussionsupporting

confidence: 91%

“…Studies of this putative marker of the tumour matrix are also of considerable interest in colorectal cancer (Sugawara et al, 1991;Riedel et al, 1992;Sakai et al, 1993;Hauptmann et al, 1995;Riedel et al, 1995) because of the potential involvement of tenascin (or tenascin-like proteins) in cell adhesion and invasion during the metastatic process. Moreover, diagnostic and possibly therapeutic monoclonal antibodies, specific for the larger tenascin isoforms present in tumours, have been developed (Leprini et al, 1994).…”

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confidence: 99%

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Stromal tenascin distribution as a prognostic marker in colorectal cancer

Kressner

Lindmark²,

Tomasini-Johansson³

et al. 1997

Br J Cancer

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Summary A total of 169 colorectal adenocarcinomas, obtained from patients with a median follow-up of 6.5 years, were studied with immunohistochemical staining on cryosections using a monoclonal anti-tenascin antibody to evaluate the possible association between the staining patterns and tumour stage, tumour differentiation and survival. We found two different staining patterns in the tumour stroma -a diffuse stromal fibrillar staining in 92 out of 169 (54%) tumours and a subglandular staining in the remaining 77 tumours. When the entire group of patients (P < 0.01) and the group of potentially cured patients (P < 0.03) were analysed univariately, it was found that diffuse stromal fibrillar staining was associated with a shorter survival time than subglandular staining. In a multivariate analysis, the Dukes' stage and age were independent prognostic factors, whereas the tenascin expression did not retain a clear independent relationship to survival (P = 0.06).Hence, it appears that the tumour expression of tenascin may be a potential prognostic marker in colorectal cancer, in so far as a diffuse stromal fibrillar staining pattern seems to indicate an increased risk of poor outcome. However, after adjustment for age and Dukes' stage, the additional prognostic value of tenascin remains to be established in further analyses.Keywords: tenascin; colorectal cancer; tumour stage; tumour differentiation; survival; immunohistochemistry Tenascin is a large hexameric extracellular matrix protein that is present during embryonic development but essentially absent in normal adult tissues (Schenk and Chiquet-Ehrismann, 1994) and is expressed only at low levels or in a very restricted distribution. Several tenascin isoforms have been described . Tenascin has been suggested to be of importance in the normal healing process and in tumours, in which its role is presumed to be connected with cell adhesion and detachment, cell growth, cell migration and angiogenesis (Mackie et al, 1988;Ekblom and Aufterheide, 1989;Erickson and Bourdon, 1989; ChiquetEhrismann, 1993;Hahn et al, 1995; Joshi et al, 1995). It has been proposed that, although tenascin has no cell adhesion activity, it does affect the cell shape and, thus, may inhibit cell attachment to other extracellular proteins, including fibronectin (Mackie, 1994). It is also thought that tenascin plays a role in coordinating the provisional extracellular matrix surrounding the cancer tissue (Sakakura and Kusakabe, 1994).Several reports have shown an up-regulation of tenascin in various tumour stroma, such as breast (Moch et al, 1993;Shoji et al, 1993;Yoshida et al, 1995), lung (Natali and Zardi, 1989), prostatic (Ibrahim et al, 1993) and gastric carcinomas (Ikeda et al, 1995;Ilunga and Iriyama, 1995). Studies of this putative marker of the tumour matrix are also of considerable interest in colorectal cancer (Sugawara et al, 1991;Riedel et al, 1992;Sakai et al, 1993;Hauptmann et al, 1995;Riedel et al, 1995) because of the potential involvement of tenascin (or tenascin-like proteins) i...

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Section: Discussionsupporting

confidence: 91%

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confidence: 99%

Stromal tenascin distribution as a prognostic marker in colorectal cancer

Kressner

Lindmark²,

Tomasini-Johansson³

et al. 1997

Br J Cancer

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“…Further investigations have shown that TN also contains a site that promotes cell adhesion (Spring et al, 1989). These properties, combined with the observations that TN is involved in the migration of cells during development of embryonic tissues and the migration of keratinocytes in skin wounds (Latijnhouwers et al, 1994), leads to speculation that the overexpression of TN in tumours may be involved in the invasion process (Riedl et al, 1995;Ishihara et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Expression of the extracellular matrix protein tenascin in malignant and benign ovarian tumours

Wilson

Langdon²,

Lessells³

et al. 1996

Br J Cancer

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Summary The extracellular matrix protein tenascin (TN) is overexpressed in a number of solid tumours. This, however, is the first study to examine TN expression in ovarian tumours. TN protein was examined in frozen sections of 50 human ovarian tumours by immunohistochemistry. Malignant and borderline tumours showed a significantly greater incidence and intensity of stromal staining than benign tumours (P<0.0001 and P=0.038 respectively). Seven omental metastases were also examined and showed a strikingly similar protein distribution to their primary tumour counterparts. The expression pattern of different RNA isoforms, created by alternative splicing of the primary transcript, was identified using reverse transcription-polymerase chain reactions (RT-PCR). The smallest TN RNA splice variant (284 bp) was found in all tumours examined, while the appearance of larger molecular weight transcripts (-490 and 556 bp), as major forms, was predominantly limited to malignant tumours, with 9/12 malignant tumours showing this pattern compared with 1/6 benign tumours. These data suggest that malignant ovarian tumours have increased expression of TN compared with benign tumours and this may be associated with induction of specific isoforms.

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“…Two distinct stromal staining patterns have been described in colorectal cancer [11, 28, 29], and the distribution of these patterns has been proposed as a prognostic factor, in that a diffuse stromal staining pattern may indicate an increased risk of poor outcome [28, 29]. Further, elevated preoperative serum levels of tenascin-C have been reported to reflect the total tumor burden and to correlate with metastatic disease in colorectal cancer [30]. Also, a significant relationship between tenascin mRNA expression and deep invasion and the presence of lymph node metastasis has been seen in colon carcinomas [31].…”

Section: Introductionmentioning

confidence: 99%

Tenascin-C Expression and Its Prognostic Significance in Colorectal Cancer

Lundin¹,

Nordling

Lundin³

et al. 2007

Oncology

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Objective: The extracellular matrix glycoprotein tenascin-C has been proposed as a tumor marker with prognostic significance in many cancer forms, but in colorectal cancer, reported results have been controversial. The aim of this study was to evaluate the prognostic value of immunohistochemical tenascin-C expression in a series of 231 patients with colorectal cancer. Methods: Paraffin-embedded formalin-fixed specimens were stained with a tenascin-C-specific monoclonal antibody, and the stromal staining intensity and pattern were analyzed. Results: Tenascin-C immunoreactivity was observed in all 231 specimens, with a pattern of staining that was diffuse and interstitial. The staining was occasional in 39 (17%), moderate in 106 (46%) and strong in 86 specimens (37%). There was no statistically significant association between tenascin-C immunoreactivity and any of the other clinicopathological variables. The cumulative 5-year survival rates of patients with occasional and weak staining were similar (56.8 and 54.9%, respectively), while the patients with strong tenascin-C staining had a lower survival rate (46.1%). This difference in survival was not significant (p = 0.23). The staining pattern and distribution can be viewed from digitized representative microscope slides (virtual slides) at http://www.webmicroscope.net/supplements/tenascin. Conclusions: Our results indicate that immunohistochemical expression of tenascin-C is not of prognostic significance in colorectal cancer.

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Significance of tenascin serum level as tumor marker in primary colorectal carcinoma

Cited by 36 publications

References 19 publications

Stromal tenascin distribution as a prognostic marker in colorectal cancer

Stromal tenascin distribution as a prognostic marker in colorectal cancer

Expression of the extracellular matrix protein tenascin in malignant and benign ovarian tumours

Tenascin-C Expression and Its Prognostic Significance in Colorectal Cancer

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