Significance of the platelet distribution width as a severity marker for the development of preeclampsia

Yang, Sean; Cho, Soo Hyun; Kwon, Han Sung; Sohn, In Sook; Hwang, Han Sung

doi:10.1016/j.ejogrb.2013.12.036

Cited by 96 publications

(126 citation statements)

References 19 publications

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“…Notably higher PDW values of the SGA and Oligohydramnios group in both first and third trimester could not be attributed to any specific pathologic mechanism. There are two different studies in the literature about high PDW values; one of them attributed it to having high predictive value to make the diagnosis of threatened preterm labor (16), other one attributed it to having a role as a prediction marker for the severity of preeclampsia (17). Probably, patients diagnosed with SGA and oligohydramnios may share the same pathogenesis which make increase PDW values as threatened preterm labor and preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

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Are Leukocyte and Platelet Indices Associated with Small for Gestational Age Birth and/or Oligohydramnios?

Ersoy¹,

Özler²,

Öztaş³

et al. 2016

Acta Med Anatol

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Introduction:To investigate whether certain leukocyte and platelet indices predict Small for Gestational Age (SGA) birth and/ or oligohydramnios. Materials and Methods:In this retrospective study, 408 pregnant women were included, who didn't have foreknown systemic diseases and other risk factors like drug use, smoking. Patients diagnosed with SGA birth (Group-I, n=59), SGA birth and oligohydramnios (Group-II, n=46), solely oligohydramnios (Group-III, n=23) and control group (Group-IV, n=280, matched for maternal age and body mass index) were selected from medical records. Leukocyte and platelet indices in first trimester and third trimester, demographic and obstetric data were obtained from medical records. Then, groups were compared.Results: Maternal ages and body mass indices were similar among groups. Total leukocyte, neutrophil, lymphocyte and platelet counts, platelet indices (p<0.001), neutrophil to lymphocyte ratios (p<0.001) were significantly different between first and third trimester values in all patients. Platelet distribution width values of group-II in both trimester were significantly higher than ones of group-IV. Conclusion:Most hematologic parameters were not associated with SGA birth and/or oligohydramnios, but it was clarified that they differ significantly between first and third trimester. A new prospective study with larger sample size may present more definitive results.

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Section: Discussionmentioning

confidence: 99%

“…Acta Med Anatol 2016;4(1): [14][15][16][17][18][19][20] WBC in the first trimester ratio (WBC3/WBC1) values in group-I were significantly higher than in group-IV. Both NLR in the first trimester and NLR in the third trimester values were similar between two groups.…”

Section: Original Article Ersoy Et Almentioning

confidence: 99%

Are Leukocyte and Platelet Indices Associated with Small for Gestational Age Birth and/or Oligohydramnios?

Ersoy¹,

Özler²,

Öztaş³

et al. 2016

Acta Med Anatol

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“…n : number of participants with data to the corresponding parameter.Missing data: N – n .General reference range listed with reference to: a local recommendation for the Central Laboratory at Queen Ingrid Hospital, Greenland, b [22], c [23], d [24], e [25]. …”

Section: Methodsmentioning

confidence: 99%

“…When the reference range was not given from The Central Laboratory at QIH, the parameter was listed with the reference range to several relevant laboratory studies; 1) a study including Danish pregnant women [22]; 2) a database review for maternal laboratory studies [23]; 3) a study regarding platelet markers in pregnant women [24]; and 4) a reference range for RDW for healthy adults [25]. For BASO, EO, LYMPH, MONO, and NEU count, the data were presented in 109/L.…”

Section: Methodsmentioning

confidence: 99%

Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study

Knudsen

Long

Bonefeld-Jörgensen

2018

International Journal of Circumpolar Health

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The Arctic populations have high blood concentrations of persistent organic pollutants (POPs). Exposure to POPs was related to adverse health effects e.g. immune, neurological and reproductive systems. This study investigates associations between serum POP levels and haematological markers in Greenlandic pregnant women. This cross-sectional study included 189 women enrolled in 2010–2011 at the Greenlandic West coast by the inclusion criteria ≥18 years of age and had lived for 50% or more of their life in Greenland. The associations between the sum of the POP variables polychlorinated biphenyls (sumPCBs), organochlorine pesticides (sumOCPs), perfluoroalkylated substances (sumPFASs) and 24 haematological markers were analysed using linear regression adjusted for age, pre-pregnancy BMI, parity, gestation week, plasma-cotinine and alcohol intake. It showed a significantly inverse association between several haematological markers (eosinophil, lymphocyte, neutrophil and white blood cells) and sumPCBs, sumOCPs and sumPFASs. In addition, the monocyte, mean corpuscular haemoglobin concentration, plateletcrit and platelet count markers were significantly inversely associated with sumPFASs, but the haematocrit and mean erythrocyte corpuscular volume were positively associated with sumPFASs. In conclusion, exposure to POPs influenced several haematological markers, especially cell count parameters, suggesting immunosuppressive potential of POPs in Greenlandic pregnant women. The data need further investigations.

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“…Because PE can progress rapidly, it requires prompt intervention that may include observation in a tertiary care setting and termination of pregnancy, either by inducing labor or by Cesarean section, which is the only known cure for this condition [5]- [8]. As it affects multiple organs, no single, specific and cost-effective marker to predict PE has yet been proposed [9]. However, several models have been suggested but are found to be not clinically relevant [10]- [12].…”

Section: Introductionmentioning

confidence: 99%

Changes in Platelet Indices during Pregnancy as Potential Markers for Prediction of Preeclampsia Development

Nooh¹,

Abdeldayem²

2015

OJOG

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Objective: To assess whether changes in platelet indices, detectable by simple complete blood count (CBC), during pregnancy could be used as markers for prediction of development of preeclampsia (PE). Methods: A total of 2813 pregnant women who received regular antenatal care until delivery were included. Participants were divided into 3 groups: normotensive pregnant women (n = 2621), women with PE without severe features (n = 169), and women with PE with severe features (n = 23). Blood samples were collected during antenatal visits and/or during the period of in-patient hospital stay, and changes in platelet indices were compared among the three groups. Results: Platelet count (PC) was decreasing while mean platelet volume (MPV) and platelet distribution width (PDW) were increasing as PE progressed. Receiver operating characteristics (ROC) curve analysis showed that PDW had the largest area under curve (AUC) [0.980 (95% CI: 0.964 -1.000)], making it the best marker for predicting development of PE. Also, PDW showed the most statistically significant correlation with mean arterial pressure (MAP) (r = 0.902, p = 0.000), making it the best marker for predicting severity of hypertension. Conclusion: This study provides evidence that PC decreases while MPV and PDW increase as pregnancy advances, and these changes are more pronounced in PE than normotensive pregnancy. These changes predate development of PE by 2 -8 weeks and are proportional to the progress of this disorder. The selected platelet indices, especially PDW, have the potential to be utilized as markers for not only prediction of PE development but also severity of hypertension.

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Significance of the platelet distribution width as a severity marker for the development of preeclampsia

Cited by 96 publications

References 19 publications

Are Leukocyte and Platelet Indices Associated with Small for Gestational Age Birth and/or Oligohydramnios?

Are Leukocyte and Platelet Indices Associated with Small for Gestational Age Birth and/or Oligohydramnios?

Persistent organic pollutants and haematological markers in Greenlandic pregnant women: the ACCEPT sub-study

Changes in Platelet Indices during Pregnancy as Potential Markers for Prediction of Preeclampsia Development

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