In this study, we have investigated magnetohydrodynamic Couette flow across a deformable porous regime with entropy generation having equal suction and injection velocities. The aim of this work is to analyze the novel impact of thermophoresis deposition, activation energy, and magnetic effect by considering viscosity and thermal conductivity as dependent on temperature in a deformable porous regime. The dimensional equations are turned into nonlinear ordinary differential equations (ODEs) through proper similarity variables. To solve these ODEs, we utilized the MATLAB bvp4c approach. Graphs are used to study the behavior of many physical parameters such as skin friction, Bejan number, velocity, displacement, entropy generation, concentration, and temperature. It is found that the viscosity parameter reduces the solid displacement, whereas it enhances the fluid concentration. Due to the impact of suction/injection and drag parameters, fluid velocity becomes reduced. The thermal conductivity parameter raises entropy generation and temperature, but it decays the Bejan number. The volume fraction parameter plays an interesting behavior in skin friction. Moreover, the current work is compared with prior research work while neglecting the newly introduced effects, and the results remain consistent.