Significant association between leukoaraiosis and metabolic syndrome in healthy subjects

Abstract

Article abstractObjective: To investigate the relationship between leukoaraiosis (LA), which has been considered as an intermediate substitute of ischemic brain damages, and metabolic syndrome (MetS) that attracts attention as a risk factor for cerebrovascular diseases, in healthy subjects derived from various age groups. Methods:We studied 1,030 healthy persons at ages between 28 and 78 years (mean, 52.7 years) with no past history of stroke who visited a health care facility for routine health checkups. MetS was defined using the criteria of the National Cholesterol

Higher intraocular pressure is associated with leukoaraiosis among middle-aged and elderly Koreans without glaucoma or dementia

“…[14][15][16] Atherosclerotic changes in ocular vessels and the cerebral artery that are associated with cardiometabolic risk factors may be responsible for elevated intraocular pressure and leukoaraiosis. 17,18 Indeed, in the present study, hypertension and diabetes mellitus were more prevalent in the leukoaraiosis group. Atherosclerotic changes in the ocular vessels and cerebral artery have been simultaneously observed in patients with glaucoma.…”

Elevated Levels of Hemoglobin A1c Are Associated With Cerebral White Matter Disease in Patients With Stroke

“…Previous studies assessing the relationship between WMD and DM, metabolic syndrome, dyslipidemia, higher levels of fasting glucose, and increased insulin resistance yielded controversial results. 11,12,14,16,17,22,23 In these studies, however, HbA1c was not analyzed. A similar study by Heo et al 25 showed rather unexpected negative association between HbA1c and severe WMD in diabetic patients.…”

Metabolic Syndrome, Prediabetes, and Brain Abnormalities on MRI in Patients With Manifest Arterial Disease: The SMART-MR Study

“…MetS has been reported to be a risk factor for ischemic stroke and silent brain infarction in studies among healthy people and in patients with coronary heart disease (8-11), but in 2,197 Chinese patients with type 2 diabetes without cerebrovascular disease at baseline, MetS failed to predict ischemic stroke and in contrast, macrovascular disease (ischemic heart disease and middle cerebral artery stenosis), and microvascular disease (retinopathy) contributed to the occurrence of incident stroke independently (12). No association between MetS and WMH was found in middle-aged people (n = 1,812) in whom relatively crude visual rating methods were applied (6), but in another study among 1,030 healthy subjects using the same rating scale, MetS was associated with every grade of leukoaraiosis (13).…”

“…Previous crosssectional studies showed no differences in brain volume between subjects with and without MetS (5,6), but high HbA 1c has been identified as a risk factor for a greater rate of brain atrophy over 6 years in a prospective study (7). For the relation of MetS with ischemic stroke, contradictory results have been reported (8)(9)(10)(11)(12), as well as for the relation of MetS with WMH (5,13). Not all of these studies used volumetric assessment of WMH and measures of brain atrophy.…”