Significant Association between <i>IL-17F</i> Promoter Region Polymorphism and Susceptibility to Asthma in a Korean Population

Abstract

Background: Individual differences in susceptibility to asthma would be expected because of common DNA variants of single nucleotide polymorphisms (SNPs) across populations. The pro-inflammatory cytokine IL-17F has homology with the IL-17 motif and induces the expression of other inflammatory cytokines in airway epithelial cells. This study aimed to identify IL-17F gene polymorphisms and to determine a possible association between these polymorphisms and susceptibility to asthma through a case-control study in a Korean population. Methods: We identified SNPs in the IL-17F gene by sequencing. Genotyping was conducted using the high-resolution melting (HRM) method on 424 asthma patients and 548 healthy controls. Results: The genotype and allele frequencies of rs1889570 SNP were significantly different between asthma patients and healthy controls (p = 0.001 and 0.002, respectively). The rs1889570 SNP genotype was also positively associated with the number of peripheral blood eosinophils in asthma patients (p = 0.03). The frequencies of haplotypes AA (p = 0.01), GG (p = 0.01) and AG (p = 0.006) were significantly different between asthma patients and healthy controls. Conclusions: In this study, we confirmed that the rs1889570 polymorphism of the IL-17F gene is associated with susceptibility to asthma in a Korean population.

Pathogenesis of severe asthma

“…These associations are consistent with in vitro findings that IL‐17A can promote neutrophil migration through IL‐8 stimulation by facilitating neutrophil transmigration . Various studies have identified genetic variants of IL‐17A and IL‐17F to be associated with asthma risk but none has dealt with severe asthma . Hence, IL‐17 signalling pathway may be associated with a subset of patients characterized as having ‘neutrophilic’ asthma.…”

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

“…Multiple previous studies have reported an association between IL-17 gene polymorphisms and autoimmune diseases (Jin et al, 2011;Zhang et al, 2013;Maalmi et al, 2014;Shen et al, 2015). Jin et al (2011) reported an association between IL-17 gene polymorphisms and susceptibility to asthma in a Korean population, and suggested that the rs1889570 polymorphism was correlated with the development of asthma.…”

“…Jin et al (2011) reported an association between IL-17 gene polymorphisms and susceptibility to asthma in a Korean population, and suggested that the rs1889570 polymorphism was correlated with the development of asthma. Shen et al (2015) reported that the IL-17 rs2275913 and rs3819024 variant alleles were associated with a decreased risk of rheumatoid arthritis, while the IL-17 rs3819025 and rs8193036 variant alleles were correlated with an increased risk of rheumatoid arthritis.…”

Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects

“…Although the Th17 cytokines, IL-17A and IL-17F [26,27], and SNPs of IL-17A or IL-17F gene [28][29][30][31] have previously been shown Table 3 Associations of genotype with allergic rhinitis or allergic rhinitis plus asthma risk. to be associated with asthma, to our knowledge this is the first study to report a genetic association between IL-17A and IL-17F genes and allergic rhinitis.…”