Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population*

Özdaş, Talih; Özdaş, Sibel; Babademez, Mehmet Alı; Muz, Sami̇ Engi̇n; Atilla, Mahmut Huntürk; Baştimur, Sibel; İzbırak, Afife; Kurt, Kenan; Öz, Işılay

doi:10.3906/sag-1512-93

Cited by 3 publications

(5 citation statements)

References 36 publications

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“…This susceptibility to infection may be caused by genetic dispositions. The role of different variations in inflammatory genetic factors, such as polymorphisms of mannose binding lectin (MBL), toll-like receptors (TLRs), secretoglobulins (SCGBs), or IL-10, were analyzed [ 20 , 21 , 22 , 23 ]. Grasso et al found that the MBL2 00 genotype is a prognostic marker of AH in children [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, Babademez et al stated that TLR4 polymorphisms were associated with an increased risk of AH, but they did not find the same association when they analyzed TLR2 polymorphisms [ 20 ]. In addition, in the work of Özdaş et al, the presence of single nucleotide polymorphisms (SNPs) of secretoglobulins were associated with an increased risk of AH [ 22 ]. Another study demonstrated the role of the IL-10 genotype GG in resistance to hypertrophy [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

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Siblings’ Risk of Adenoid Hypertrophy: A Cohort Study in Children

Zwierz

Domagalski

Masna

et al. 2023

IJERPH

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Background: The aim of this study was to compare adenoid size in preschool-age siblings using flexible nasopharyngoscopy examination (FNE) when they reach the same age. The occurrence of adenoid symptoms in these patients was also analyzed. This study was conducted to analyze the adenoid size in siblings when they reach the same age and substantiate a correlation between adenoid hypertrophy (AH) and adenoid symptoms. Methods: We analyzed and reported on the symptoms, ENT examination results, and FNE of 49 pairs of siblings who were examined at the same age. Results: There was a strong association in adenoid size between siblings when they are at a similar age (r = 0.673, p < 0.001). Second-born children whose older sibling had IIIo AH (A/C ratio > 65%) had a risk of IIIo AH 26 times greater than patients whose older sibling did not have IIIo AH (OR = 26.30, 95% CI = 2.82–245.54). Over 90% of snoring children whose siblings had confirmed IIIo AH would develop IIIo AH by the time they reach the same age. Second-born children in whom snoring occurs and whose older siblings have a IIIo AH have about a 46 times higher risk of IIIo AH compared to patients who did not meet these two conditions (p < 0.001, OR = 46.67, 95% CI = 8.37–260.30). Conclusions: A significant familial correlation between adenoid size in siblings when they reach the same age was shown. If the older sibling has a confirmed overgrown adenoid (IIIo AH) and their younger sibling presents adenoid symptoms, particularly snoring, it is highly probable that they will also have an overgrown adenoid.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Siblings’ Risk of Adenoid Hypertrophy: A Cohort Study in Children

Zwierz

Domagalski

Masna

et al. 2023

IJERPH

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“… 27 Genetic factors include, among others, polymorphisms in genes coding: SCGB1D4 (IFN-γ stimulated cytokine regulating chemotaxis of immune cells), TLR2 and TLR4 (play a key role in the regulation of the immune system through recognition of molecular patterns commonly found on pathogens (pathogen-associated molecular patterns)). 28 29 …”

Section: Pathogenesis Of Ahmentioning

confidence: 99%

“…Moreover, elevated levels of proinflammatory cytokines such as high-sensitivity C reactive protein, IL-1 and IL-10, interferon-γ (IFN-γ), TNF-α (tumor necrosis factor α) as well as intercellular adhesion molecule-1 in children with AH have been observed 27. Genetic factors include, among others, polymorphisms in genes coding: SCGB1D4 (IFN-γ stimulated cytokine regulating chemotaxis of immune cells), TLR2 and TLR4 (play a key role in the regulation of the immune system through recognition of molecular patterns commonly found on pathogens (pathogen-associated molecular patterns)) 28 29…”

Section: Pathogenesis Of Ahmentioning

confidence: 99%

Adenoid hypertrophy in children: a narrative review of pathogenesis and clinical relevance

Niedzielski

Chmielik

Mielnik–Niedzielska

et al. 2023

bmjpo

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Adenoids (nasopharyngeal tonsils), being part of Waldeyer’s ring, are masses of lymphoid tissues located at the junction of the roof and the posterior wall of the nasopharynx. Adenoids play an important role in the development of the immune system and serve as a defence against infections, being the first organs that come into contact with respiratory and digestive antigens. The causes of adenoid hypertrophy are not fully known. They are most likely associated with aberrant immune reactions, infections, environmental exposures and hormonal or genetic factors. The aim of this review is to summarise the current knowledge of adenoid hypertrophy in children and associated diseases. Adenoid hypertrophy has many clinical manifestations that are frequent in the paediatric population and is accompanied by various comorbidities.

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“…Обнаружение у большинства пациентов с гипертрофией глоточной миндалины вирусов группы герпеса, аденовирусов, человеческого бокавируса подчеркивает их лимфотропность и значимую роль в развитии патологии лимфоглоточного кольца [3,4]. В научной литературе описаны данные, продемонстрировавшие значимость полиморфизма отдельных нуклеотидов генов SCGB1D4 (IIS) и Ugrp2 в повышении риска развития гипертрофии аденоидов у детей и влияние мутации в гене DEFB1 на риск формирования хронического увеличения аденоидной ткани [5,6]. В публикациях отмечено негативное воздействие табачного дыма и неблагоприятных факторов окружаю щей среды на аденоиды у детей, проживающих в крупных городах и промышленных центрах, по сравнению с детьми пригородов и сел.…”

Section: Introductionunclassified

The effectiveness of the use of topical bacterial lysates in frequently ill children with pharyngeal tonsil hypertrophy and/or exacerbation of chronic adenoiditis

Vladimirova,

Martynova

2023

Medicinskij sovet

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Introduction. The issue of diseases of the lymphopharyngeal ring in childhood remains extremely relevant in the outpatient practice of otorhinolaryngologists.Aim. To study the effectiveness of the use of bacterial lysates (IRS-19, Imudon) in frequently ill children with adenoid hypertrophy, exacerbation of chronic adenoiditis at the outpatient stage of treatment.Materials and methods. Examination and treatment of 67 children (35 girls and 32 boys) with hypertrophy of the pharyngeal tonsil and/or exacerbation of chronic adenoiditis at the age of 3 to 14 years (average age was 8.7 ± 6.2 years) was carried out based on two state polyclinics in Samara during the period from May 2023 to August 2023. The patients were divided into 2 groups matched by sex and age: the control group (n = 33) and the main group (n = 34), which additionally used topical bacterial lysate IRS-19 and a mixture of bacterial lysates Imudon. Complaints were assessed, ENT examination, endoscopic endonasal revision of the nasal cavity and nasopharynx, acoustic impedancemetry was performed, study of smears-prints from the structures of the pharyngeal tonsil, a serological blood test (ELISA) with the determination of IgG and IgM for herpes viruses (types I, II, IV, VI), cytomegalovirus and Epstein-Barr virus were conducted on the first day of treatment, on the 10th day of treatment and in dynamics after 3 months.Results. By the 10th day in the main group, nasal congestion decreased in 73% of cases, discharge from the anterior nasal cavity in 78% of cases; the size of adenoid vegetations decreased and reached grade I in 34.4% of cases, grade II adenoids were detected in 49.3% of cases, in the control group the size of adenoids corresponded to grade II (50.5% of cases) and grade III (34.7% of cases). In dynamics, after 3 months of observation, children in the main group, using bacterial lysates (IRS-19, Imudon), showed a significant decrease in episodes of ARVI and adenoiditis, in contrast to the control group, where the incidence was 2.3 times higher.Discussion. A significant decrease in the frequency of complaints from patients in the main group and a more pronounced decrease in the size of the pharyngeal tonsil were revealed.Conclusions. Thus, the results of the study indicate the therapeutic and preventive effectiveness of including bacterial lysates (IRS-19, Imudon) in complex therapy in children with hypertrophy of the pharyngeal tonsil and/or exacerbation of chronic adenoiditis.

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Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population*

Cited by 3 publications

References 36 publications

Siblings’ Risk of Adenoid Hypertrophy: A Cohort Study in Children

Siblings’ Risk of Adenoid Hypertrophy: A Cohort Study in Children

Adenoid hypertrophy in children: a narrative review of pathogenesis and clinical relevance

The effectiveness of the use of topical bacterial lysates in frequently ill children with pharyngeal tonsil hypertrophy and/or exacerbation of chronic adenoiditis

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