2019
DOI: 10.3389/fnins.2019.01335
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Significant Effects of Maternal Diet During Pregnancy on the Murine Fetal Brain Transcriptome and Offspring Behavior

Abstract: Background: Maternal over-and undernutrition in pregnancy plays a critical role in fetal brain development and function. The effects of different maternal diet compositions on intrauterine programing of the fetal brain is a lesser-explored area. The goal of this study was to investigate the impact of two chowmaternal diets on fetal brain gene expression signatures, fetal/neonatal growth, and neonatal and adult behavior in a mouse model. Methods: Throughout pregnancy and lactation, female C57Bl/6J mice were fed… Show more

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Cited by 24 publications
(17 citation statements)
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References 142 publications
(183 reference statements)
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“…It has also been reported that HSD during pregnancy and lactation induced a significant increase in mitochondrial superoxide in postnatal day (PND) 7 offspring’s hippocampus and prefrontal cortex 10 . The specific detriment in those brain regions may result in hyperactivity, altering social activity, and emotional behavior impairment 14 . Combined with all of the above evidences, it implied that maternal HSD might affect the offspring’s brain structural and functional maturation and lead to some serious consequences.…”
Section: Introductionmentioning
confidence: 95%
See 1 more Smart Citation
“…It has also been reported that HSD during pregnancy and lactation induced a significant increase in mitochondrial superoxide in postnatal day (PND) 7 offspring’s hippocampus and prefrontal cortex 10 . The specific detriment in those brain regions may result in hyperactivity, altering social activity, and emotional behavior impairment 14 . Combined with all of the above evidences, it implied that maternal HSD might affect the offspring’s brain structural and functional maturation and lead to some serious consequences.…”
Section: Introductionmentioning
confidence: 95%
“…10 The specific detriment in those brain regions may result in hyperactivity, altering social activity, and emotional behavior impairment. 14 Combined with all of the above evidences, it implied that maternal HSD might affect the offspring's brain structural and functional maturation and lead to some serious consequences.…”
mentioning
confidence: 97%
“…The magnitude of differences between cohorts aligned with the principal imaging axis, suggesting a differential impact of perinatal adversity on cortical development that is potentially encoded by a selective vulnerability across regions due to differential maturation rates. Adverse intrauterine environments can result in altered patterns of fetal gene expression and brain development [74][75][76][77][78][79], and we demonstrate overlapping genetic associations between alterations in preterm cortical structure and differential expression in an experimental model of fetal hypoxic-ischaemic brain injury [57]. However, the antecedents and impacts of preterm birth on brain development are multifactorial, and we remain cautious on speculating about the causal mechanisms that may underlie the relationships observed in this study without further empirical evidence.…”
Section: Plos Biologymentioning
confidence: 62%
“…Ma et al report that in early to mid-gestational nutrient-restricted ewes, the brain weight of the fetus was transiently reduced at mid-gestation and returned to normal levels at term [19]. With regard to the qualitative effect of malnutrition on the brain, Edlow et al showed that differences in the relative deficiency in micronutrients including minerals, vitamins, and amino acids provoked differential expression of more than 1000 genes in the mice embryonic brain, such as brain-derived neurotrophic factor (BDNF) and Kruppel-like factor 3 (KLF3), a transcription regulator linked to various neurological disorders [20]. In addition, protein restriction during the perinatal period is known to impair hippocampal development, leading to reduced BDNF levels.…”
Section: Discussionmentioning
confidence: 99%