Significant Increase of Benign Endometrial Cells on Papanicolaou Smears in Women Using Hormone Replacement Therapy

Mount, Sharon L.; Wegner, Elisabeth K.; Eltabbakh, Gamal H.; Olmstead, Jennifer I.; Drejet, Anne

doi:10.1097/00006250-200209000-00009

Cited by 8 publications

(19 citation statements)

References 8 publications

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“…Even higher prevalence figures of 1.1% and 1.3% endometrial cells in postmenopausal women were recently reported. 21,28 These figures are in striking contrast to those of older and some newer studies, in which only 0.01%, 21 0.03%, 14 0.06%, 10 and 0.11% 11 of Pap smears showed benign endometrial cells that were either outof-phase or occurred in postmenopausal women. A study contemporary with the last two studies 10,11 specifically examining the frequency of finding endometrial cells in Pap smears 3 found endometrial cells in 0.6% of postmenopausal women.…”

Section: Discussioncontrasting

confidence: 61%

“…Women taking estrogen supplements have increased rates of benign endometrial cells seen on Pap tests, most likely derived from normal endometrium stimulated by exogenous estrogens. 28 Mount and coworkers 28 found that women Ն 50 years of age taking HRT have a relative prevalence of 1.56 of benign endometrial cells on Pap test (1.5% vs. 1%). Presumably, the recent and possibly permanent decline in the popularity of HRT will affect future studies in this area.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Significance of benign endometrial cells in papanicolaou tests from women aged ≥ 40 years

Thrall

Kjeldahl

Savik

et al. 2005

Cancer

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Significance of benign endometrial cells in papanicolaou tests from women aged ≥ 40 years

Thrall

Kjeldahl

Savik

et al. 2005

Cancer

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“…These findings demonstrate that women on HRT have a reduced incidence of endometrial pathology, which is in agreement with findings in a previous study. 12 All (100.00%) of the women with endometrial carcinoma presented with AUB, and 86.27% of women with endometrial pathology other than endometrial carcinoma presented with AUB. Irregular menstruation is known to be associated with perimenopausal status.…”

Section: Hormone Replacement Therapymentioning

confidence: 97%

“…A significant decrease in the prevalence of endometrial carcinoma was noted in those on HRT. 12 One limitation of this study was that Pap tests were counted as significant follow-up after the initial diagnosis of endometrial cells. Histologic sampling or ultrasonographic measurements of endometrial thickness and hysteroscopic analysis are much more reliable as follow-up procedures.…”

Section: Hormone Replacement Therapymentioning

confidence: 99%

Clinical Significance of Reporting Benign-Appearing Endometrial Cells in Pap Tests in Women Aged 40 Years and Over

Jones

Frain²,

Crabtree³

2009

Acta Cytologica

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“…Previous studies showed Endometrial cells on Pap tests have been associated with normal endometrial findings in 22-97% of women, polyps in 1-41%, hyperplasias 1-20%, atypical hyperplasia in 0.6-8%, and carcinoma in 1-15% [42,43,44].…”

Section: Discussionmentioning

confidence: 96%

Manual Liquid Based Cytology in Diagnosis of Gynecologic Pathology

Manoli¹

2016

CRJ

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Abnormal uterine bleeding (AUB) is a commonly encountered complaint in gynecology department. Endometrial cancer is the fourth most common malignancy in women and the most frequent gynecological cancer in developed countries. With 5,28, 000 new cases every year, cervical cancer is the fourth most common cancer affecting women worldwide, after breast, colorectal, and lung cancers. Though the cytological examination has been the mainstay for early detection of cervical cancer, and found to be useful in detection of endometrial cancer, its widespread use has not been possible in the developing countries due to paucity of resources, man power and other facilities Its sensitivity reduces to less than 50% when there is presence of obscuring blood, inflammation or thick areas of overlapping epithelial cells. Manual Liquid Based Cytology (MLBC) is a cost effective technique that enables cells to be suspended in a monolayer and thus improve detection of precursor lesions and specimen adequacy. The residual sample can be used for other tests like Cell block and immunocytochemistry. Objectives: 1. To improve the diagnosis of gynecological cancers by a method called as Manual Liquid Based Cytology (MLBC). 2. To study a cost effective method of studying both endometrial and cervical cancer with help of ancillary techniques like cellblock, immunocytochemistry 3To compare the findings between conventional pap smear (CPS) and MLBC in detection of gynecological conditions of endometrium and cervix. Methodology: Samples were collected using Ayres spatula by split sample technique from transformation zone of cervix which included outpatients of gynecology dept. The women were aged between 20-60 years, 82 cases with bleeding history were taken to study endometrial pathology, while 100 cases of white discharge per vagina were selected to study the cervix. 60 cases were later subjected to ancillary studies like cellblock with Immunocytochemistry. Histopathological correlation was done for cases wherever possible. Results: The study on endometruim showed MLBC is more sensitive and specific than CPS in diagnosis of malignant lesions. The contingency coefficient for LBC/Histopathology V/s CPS/Histopathology was 0.572 V/s 0.556. It was observed for cervical lesion that increased detection rate was 150% for low grade intraepithelial lesion. The Positive predictive value for diagnosing neoplastic lesions on cell blocks was 75%, while Concordance Rate of CB/Histopathology Vs CPS/Histopathology was 74% vs. 54%. Conclusion: MLBC is a cost effective method for detections of cancerous lesions of endometruim and cervix.

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Significant Increase of Benign Endometrial Cells on Papanicolaou Smears in Women Using Hormone Replacement Therapy

Cited by 8 publications

References 8 publications

Significance of benign endometrial cells in papanicolaou tests from women aged ≥ 40 years

Significance of benign endometrial cells in papanicolaou tests from women aged ≥ 40 years

Clinical Significance of Reporting Benign-Appearing Endometrial Cells in Pap Tests in Women Aged 40 Years and Over

Manual Liquid Based Cytology in Diagnosis of Gynecologic Pathology

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