Significant Increase of IL-8 Sputum Levels in Treatment Resistant Severe Asthma Compared with Difficult to Treat Severe Asthma Patients

E, Auteri S Glenda

doi:10.4172/2157-7412.1000218

Cited by 4 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-17A orchestrate the neutrophilic influx into the airways [22], but on other hand there are growing evidence that IL-17A enhance Th2 mediated immune response [10,24,25]. Other potent chemoattractant of neutrophils in the airways is IL-8 [26], found to be elevated in serum [27], BAL [8] and sputum of treatment-refractory severe asthma [28].…”

Section: Introductionmentioning

confidence: 99%

Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A in pre-defined groups of adult patients with moderate and severe bronchial asthma

Dimitrova

Youroukova

Ivanova‐Todorova

et al. 2019

Respiratory Medicine

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A in pre-defined groups of adult patients with moderate and severe bronchial asthma

Dimitrova

Youroukova

Ivanova‐Todorova

et al. 2019

Respiratory Medicine

View full text Add to dashboard Cite

“…IL-8 is a chemokine of EOS and neutrophils, which play a decisive role in asthma aggravation, severe asthma, refractory asthma and hormone-resistant asthma, and promote the occurrence of airway remodeling by increasing the migration and proliferation of ASMCs. Studies revealed that (8,9) in patients with severe resistant asthma, the level of IL-8 was significantly increased in sputum, and IL-8 could enhance the contraction of ASM by increasing the expression of L-shaped Ca 2+ . More interestingly (10), asthma, which is mainly characterized by neutrophil inflammation, has an increased bacterial load and a unique microbiota composition, and is accompanied by excessive inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

“…Glucocorticoid is the first choice of drugs for asthma prevention and treatment, which can effectively inhibit airway inflammation and the proliferation of ASMCs, and reduce AHR (7). Patients with severe or refractory asthma have poor treatment outcomes, despite adhering to highdose inhaled corticosteroids, resulting in persistent or recurrent symptoms (8). Repeated exposure to allergens can cause glucocorticoid insensitivity in asthmatic mice (9).…”

Section: Introductionmentioning

confidence: 99%

The role and mechanism of 1,25-dihydroxyvitamin D3 in regulating the Rho-kinase signaling pathway in asthmatic rats

Tian

Chen

et al. 2021

Transl Pediatr

View full text Add to dashboard Cite

Background: Bronchial asthma (referred to as asthma in the present study) is the most common chronic airway inflammatory disease in childhood. The present study aimed to investigate the effect ofwhich is closely associated with asthmatic airway smooth muscle cells (ASMCs), and explored its role and mechanism in the Rho-kinase signaling pathway. Methods: The acute asthma model was induced by ovalbumin (OVA) and pertussis bacillus, and ASMCs obtained from asthmatic rats were cultured in vitro. These cells were randomly divided into five groups: control (N) group, TNF-α (TNF) group, 1,25-(OH) 2 D 3 (VD) group, dexamethasone (DXM) group, and 1,25-(OH) 2 D 3 + DXM (L) group. The protein expression levels of VDR, ROCK, MLC20 and P-MLC20 were detected by western blot, and the mRNA expression levels of VDR, ROCK, MLC20 and P-MLC20 were detected by real-time quantitative PCR.Results: The expression of ROCK, MLC20 and P-MLC20 in each treatment group were significantly lower, when compared to the TNF group (P<0.05), but this remained stronger than (P<0.05) or similar to (P>0.05) that in the N group. Conclusions:The regulation mechanism of 1,25-(OH) 2 D 3 in alleviating asthma should be correlated to its regulation of the expression of related signaling molecules in the Rho-kinase signaling pathway, and this effect may be achieved by regulating the mRNA and protein expression of the VDR gene.

show abstract

“…Two possible phenotypes based on the inflammatory process have been proposed: Th2 asthma, which is characterized by relatively higher blood eosinophilic counts and higher exhaled nitric oxide (FeNO, which is produced by the Th2-regulated nitric oxide synthase enzyme), and non-Th2 asthma, which is typified by relatively lower eosinophils counts and lower FeNO [1,2]. These two phenotypes respond very differently to treatment with inhaled corticosteroids [3], and the airway microbiota might be one possible explanation for this. With the polymerase chain reaction (PCR) and 16s RNA gene-sequencing techniques, differences in the microbiota between asthma phenotypes [4][5][6][7][8] and allergic inflammations [2,9] were previously identified.…”

Section: Introductionmentioning

confidence: 99%

Airway Microbiome Composition and Co-Occurrence Network Are Associated with Inflammatory Phenotypes of Asthma

Li,

Zou,

et al. 2023

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Introduction: The composition and co-occurrence network of the airway microbiome might influence the asthma inflammatory phenotype. Airway microbiota change with asthma phenotypes, and the structure of the bacterial community in the airway might differ between different asthma inflammatory phenotypes and may also influence therapy results. Identifying airway microbiota can help to investigate the role that microbiota play in the asthma inflammatory process. Methods: Induced sputum from 55 subjects and 12 healthy subjects from Beijing, China, was collected and analyzed for bacterial microbiota. Microbiome diversity, composition, co-occurrence networks, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were predicted and compared between the study groups. Results: Significant differences in the sputum microbiome composition, co-occurrence network, and predicted functional pathways were observed between the two inflammatory phenotypes. Asthmatics in the low FeNO group exhibited lower α-diversity in the sputum microbiota and had higher abundance of the phylum Proteobacteria compared with that of the high FeNO group. The network in the high FeNO group was more “closed” and “connected” compared with that of the low FeNO group, and an alteration in the abundance of keystone species T. socranskii was found. Significantly different predicted metabolic subfunctions including nucleotide metabolism, lipid metabolism, energy metabolism, replication and repair, and drug resistance antimicrobial and carbohydrate metabolism between the two studied phenotypes were also observed. Conclusion: Our findings confirm that the airway microbiota is associated with the asthma inflammation process. The differences in the airway microbiome composition and co-occurrence network may affect distinct asthma inflammatory phenotypes, suggesting the possibility that more targeted therapies could be applied based on the airway bacterial genera.

show abstract

Significant Increase of IL-8 Sputum Levels in Treatment Resistant Severe Asthma Compared with Difficult to Treat Severe Asthma Patients

Cited by 4 publications

References 21 publications

Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A in pre-defined groups of adult patients with moderate and severe bronchial asthma

Serum levels of IL-5, IL-6, IL-8, IL-13 and IL-17A in pre-defined groups of adult patients with moderate and severe bronchial asthma

The role and mechanism of 1,25-dihydroxyvitamin D3 in regulating the Rho-kinase signaling pathway in asthmatic rats

Airway Microbiome Composition and Co-Occurrence Network Are Associated with Inflammatory Phenotypes of Asthma

Contact Info

Product

Resources

About