Significant intraocular pressure associated with open-angle glaucoma: Korea National Health and Nutrition Examination Survey 2010-2011

Kim, Ko Eun; Kim, Joon Mo; Lee, Jungmin; Lee, Mi Yeon; Park, Ki Ho

doi:10.1371/journal.pone.0235701

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…These observations suggest a potential link between UA, glaucoma development, and oxidative stress in the pathogenesis of PACG. [22][23][24]…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin D and Uric Acid Levels in Glaucoma Patients: A Comprehensive Investigation

Sachdeva,

Kumar,

Malik

2023

Indian Journal of Medical Biochemistry

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Objective: Glaucoma is an eye condition characterized by optic nerve damage due to inflammation and oxidative stress, often associated with increased intraocular pressure (IOP). Vitamin D, a fat-soluble vitamin with anti-inflammatory properties, and uric acid (UA), an antioxidant molecule capable of scavenging nitrogen radicals and superoxide in plasma, were the specific biomarkers of interest in this research. Therefore, the aim of this study was to assess serum levels of vitamin D and UA in glaucoma patients within the North Indian population. Materials and methods:The study enrolled 45 age and sex-matched controls and 45 glaucoma patients. Serum levels of vitamin D and UA were measured using the radioimmunoassay (RIA) and enzymatic methods, respectively. Results: The analysis revealed that the mean of vitamin D in the test group was 23.42 ± 6.56 (ng/mL), while in the control group, it was 29.28 ± 2.58 (ng/mL). Similarly, the UA level was 4.57 ± 1.19 (mg/dL) in the test and 5.87 ± 1.74 in the control. Conclusion:The present research demonstrated that the level was significantly lowered in both vitamin D and UA in glaucoma patients compared to healthy individuals. These findings emphasize the importance of routinely estimating serum vitamin D and UA in individuals suspected of having glaucoma. Additionally, the results may prove valuable for ophthalmologists in managing and monitoring patients with glaucoma.

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“…These observations suggest a potential link between UA, glaucoma development, and oxidative stress in the pathogenesis of PACG. [22][23][24]…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin D and Uric Acid Levels in Glaucoma Patients: A Comprehensive Investigation

Sachdeva,

Kumar,

Malik

2023

Indian Journal of Medical Biochemistry

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“…Multivariate adjusted models showed that men without glaucoma who drank alcohol over 2 times per month exhibited significant increases in IOP according to amount of alcohol consumed and that men who drank alcohol over 2 times per week were significantly more likely to have high IOP (≥18 mmHg). In this study, we defined 18 mmHg as a high IOP value because it has been associated with the development of OAG [ 29 , 30 ]. In subjects with glaucoma, the IOPs of men who did not consume alcohol at all were higher than among the total sample, while we observed significant increases in IOP among women glaucoma subjects who drank alcohol over 4 times per week.…”

Section: Discussionmentioning

confidence: 99%

Effects of Consumption of Alcohol on Intraocular Pressure: Korea National Health and Nutrition Examination Survey 2010 to 2011

et al. 2020

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This study researched the association between alcohol consumption, intraocular pressure (IOP), and risk of open-angle glaucoma (OAG) using nationwide population-based cross-sectional data from the Korean population based survey. Information on alcohol intake was obtained by questionnaire and comprehensive ophthalmic examinations were performed. Among a total of 6057 participants, the prevalence of OAG was 4.4% (6.0% for men and 3.0% for women). Multivariate adjusted models showed that alcohol consumption showed significant relationship with changes in IOP. In sex-stratified analyses, alcohol consumption more than 2 times per week was associated with increased IOP in men without OAG, while in women with OAG drinking alcohol more than 4 times per week was associated with increased IOP. This study showed significant differences between men and women without glaucoma who consumed alcohol more than four times per week (p-value: 0.03). Our results suggest that alcohol consumption is associated with risk of elevated IOP depending on sex and presence of glaucoma in Koreans. Therefore, patients who need to control IOP should consider the effects of alcohol consumption.

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“…IOP, a major causal risk factor for developing glaucoma and currently the only modifiable glaucoma risk factor, is affected by menopause (Vajaranant and Pasquale 2012 ; Altintas et al 2004 ; Vajaranant et al 2016 ; Panchami and S. R. et al. 2013 ; Kim et al 2020 ). Ocular hypertension (OHT), defined as an IOP > 21 mmHg, is associated with an increased risk of developing glaucoma compared to the normotensive population (IOP of 10–21 mmHg) (Morrison and Pollack 2003 ; Sommer et al 1991 ; Sugiyama 2012 ).…”

Section: Menopause and Glaucoma Riskmentioning

confidence: 99%

Evidence for Menopause as a Sex-Specific Risk Factor for Glaucoma

2022

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Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive loss of visual function and retinal ganglion cells (RGC). Current epidemiological, clinical, and basic science evidence suggest that estrogen plays a role in the aging of the optic nerve. Menopause, a major biological life event affecting all women, coincides with a decrease in circulating sex hormones, such as estrogen. While 59% of the glaucomatous population are females, sex is not considered a risk factor for developing glaucoma. In this review, we explore whether menopause is a sex-specific risk factor for glaucoma. First, we investigate how menopause is defined as a sex-specific risk factor for other pathologies, including cardiovascular disease, osteoarthritis, and bone health. Next, we discuss clinical evidence that highlights the potential role of menopause in glaucoma. We also highlight preclinical studies that demonstrate larger vision and RGC loss following surgical menopause and how estrogen is protective in models of RGC injury. Lastly, we explore how surgical menopause and estrogen signaling are related to risk factors associated with developing glaucoma (e.g., intraocular pressure, aqueous outflow resistance, and ocular biomechanics). We hypothesize that menopause potentially sets the stage to develop glaucoma and therefore is a sex-specific risk factor for this disease. Graphical Abstract

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Significant intraocular pressure associated with open-angle glaucoma: Korea National Health and Nutrition Examination Survey 2010-2011

Cited by 6 publications

References 27 publications

Serum Vitamin D and Uric Acid Levels in Glaucoma Patients: A Comprehensive Investigation

Serum Vitamin D and Uric Acid Levels in Glaucoma Patients: A Comprehensive Investigation

Effects of Consumption of Alcohol on Intraocular Pressure: Korea National Health and Nutrition Examination Survey 2010 to 2011

Evidence for Menopause as a Sex-Specific Risk Factor for Glaucoma

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