Significant Role of Small Respiratory Tracts: New Possibilities of Cyclesonide in Therapy of Bronchial Asthma

Фассахов, Р. С.

doi:10.21518/2079-701x-2017-18-56-60

Cited by 6 publications

(1 citation statement)

References 38 publications

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“…The vast majority of patients with severe asthma exhibit small airways dysfunction (SAD), which is currently considered a pathogenetic component of the disease [6,7]. The presence of SAD can predetermine the uncontrolled course of asthma, which makes it an important target for therapy [8].…”

Section: Introductionmentioning

confidence: 99%

Specificities of small airways dysfunction development in patients with mild asthma

Mineeva¹,

Аntonyuk²,

Yurenko³

et al. 2021

Russ Open Med J

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The study goal was to identify specificities of small airways dysfunction development (SAD) in patients with mild asthma. Material and Methods — The study involved 114 patients with mild asthma. Depending on the condition of their small airways, the patients were split among two groups: Group 1 of 94 patients with asthma without SAD (82.5%); Group 2 of 20 patients with asthma and SAD (17.5%). The control group consisted of 25 volunteers. SAD was diagnosed by the presence of air trapping and hyperinflation. Results — SAD was diagnosed in 17.5% of patients with mild asthma. The development of SAD was observed in 80% of asthma patients with ailment duration of over 5 years and family history of asthma. Obesity was diagnosed 1.7 times more often in patients with SAD compared with those without it. Food allergy, allergic rhinitis, allergic conjunctivitis, urticaria and bronchial obstruction were identified two or more times more often in patients with SAD compared with those without it. Among all patients with mild asthma and SAD, bronchial obstruction was detected in 55% of cases. Conclusion — The development of SAD in the presence of mild asthma is characteristic for patients with ailment duration over 5 years, family history of asthma, obesity, predominant sensitization to food allergens, and concomitant non-pulmonary allergic diseases. Bronchial obstruction is not the obligatory feature of SAD development in presence of mild asthma.

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Section: Introductionmentioning

confidence: 99%

Specificities of small airways dysfunction development in patients with mild asthma

Mineeva¹,

Аntonyuk²,

Yurenko³

et al. 2021

Russ Open Med J

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Comparative Evaluation of the Effectiveness of Anti-Inflammatory Therapy of Bronchial Asthma With Combined Inhaled Medications in Patients With Cold and Osmotic Airway Hyperresponsiveness

Пирогов¹,

Prikhodko²,

Перельман³

et al. 2019

Bulletin Physiology and Pathology of Respiration

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Small respiratory passages dysfunction in bronchial asthma

Kytikovа

Аntonyuk

Гельцер

et al. 2020

Pulʹmonologiâ (Mosk.)

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The small respiratory passages dysfunction (SRPD) is found in the vast majority of patients with bronchial asthma (BA). The SRPD is currently recognized as the important pathogenetic feature of BA. The purpose of this review is to analyze the current scientific knowledge about the poorly studied aspects of the small respiratory passages (SRR) participation in the development of pathological process in BA, as well as the impact of small bronchial dysfunction on the clinical course, the exacerbation frequency and the disease control. The importance of SRPD diagnostics in BA patients for optimal and timely treatment is discussed. The modern methods of RPD pathology diagnostics are described; their informative use in the comparative study aspect is considered.

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Significant Role of Small Respiratory Tracts: New Possibilities of Cyclesonide in Therapy of Bronchial Asthma

Cited by 6 publications

References 38 publications

Specificities of small airways dysfunction development in patients with mild asthma

Specificities of small airways dysfunction development in patients with mild asthma

Comparative Evaluation of the Effectiveness of Anti-Inflammatory Therapy of Bronchial Asthma With Combined Inhaled Medications in Patients With Cold and Osmotic Airway Hyperresponsiveness

Small respiratory passages dysfunction in bronchial asthma

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