Signs and symptoms from ectodermal organs in young Swedish individuals with oligodontia

Bergendal, Birgitta; Norderyd, Johanna; Bågesund, Mats; Holst, A

doi:10.1111/j.1365-263x.2006.00741.x

Cited by 33 publications

(35 citation statements)

References 12 publications

(24 reference statements)

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“…As it was reported previously and as in our study, the most common missing tooth was the maxillary lateral incisor, followed by bicuspids (Szepesi, 2006;Altug-Atac, 2007;Gábris, 2006). In contrast, other studies reported that bicuspids were the most common missing teeth (Bergendal et al, 2006 Onyeaso, 2006), and the data regarding fused teeth in our study were higher since they were 4.3% of the whole sample and the third more frequent diagnosed entity. It is important to have a close follow-up with these patients in order to prevent future problems during exfoliation of the fused teeth and eruption of the succedaneous one (Ledesma-Montes et al, 2012a).…”

Section: Discussioncontrasting

confidence: 54%

Developmental Alterations of Teeth in Young Patients

Ledesma‐Montes

Garcés-Ortı́z²,

Salcido³

et al. 2015

RADI

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Research motivation: The objective of this study was to know the frequency of dental developmental alterations in Mexican children and adolescents attending the Stomatological Clinics of the Faculty of Dentistry of the Universidad Nacional Autónoma de México. Research design/methodology: The files of the patients attended in our institution were reviewed and 128 were from patients among 2 and 18 years old with dental developmental alterations were selected. Data on diagnosis, age, gender and involved tooth were analyzed by Students T test and p<0.05 was considered significant. Main findings: The most frequent dental developmental alterations were: supernumeraries, missing teeth and fused teeth. Other entities were also found. Prevalence of dental alterations in the sample was 29.8% and 217 dental alterations were diagnosed. Of 217 teeth, 83.4% were permanent and 16.6% were deciduous teeth. Implications: Data obtained from this study will address the consciousness of the authorities and personnel of the institutions involved in providing health services on the importance to conduct imagenologic studies in children and adolescent population for early recognition of the intrabony pathological conditions.

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Section: Discussioncontrasting

confidence: 54%

Developmental Alterations of Teeth in Young Patients

Ledesma‐Montes

Garcés-Ortı́z²,

Salcido³

et al. 2015

RADI

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“…Thus, oligodontia represents a more severe clinical expression of disturbed tooth development than hypodontia. Individuals with oligodontia constitute approximately 1% of all individuals with hypodontia, and both conditions may be found in the same family, indicating variable expression of shared genetic factors [Polder et al, 2004;Bergendal et al, 2006]. In this study we used a population-based approach to clarify the prevalence of mutations in the AXIN2, MSX1, PAX9, EDA, EDAR, and EDARADD genes in non-syndromic oligodontia.…”

mentioning

confidence: 99%

“…In both studies the subjects were recruited from specialist centers. Epidemiological studies from a cohort of Swedish children estimated the prevalence of oligodontia with or without additional ectodermal signs and symptoms to 0.09% [Bergendal et al, 2006]. Within this cohort, structured interviews of 114 individuals with non-syndromic oligodontia showed 12 individuals (10.5%) with self-reported abnormal hair, nails, or sweating.…”

mentioning

confidence: 99%

Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes

Bergendal¹,

Klar²,

Stecksén‐Blicks³

et al. 2011

American J of Med Genetics Pt A

130

104

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Oligodontia is defined as the congenital lack of six or more permanent teeth, excluding third molars. Oligodontia as well as hypodontia (lack of one or more permanent teeth) are highly heritable conditions associated with mutations in the AXIN2, MSX1, PAX9, EDA, and EDAR genes. Here we define the prevalence of mutations in the AXIN2, MSX1, PAX9, EDA, and EDAR genes, and the novel candidate gene EDARADD in a cohort of 93 Swedish probands with non-syndromic, isolated oligodontia. Mutation screening was performed using denaturing gradient gel electrophoresis and DNA sequence analysis. Analyses of the coding sequences of the six genes showed sequence alterations predicted to be damaging or potentially damaging in ten of 93 probands (10.8%). Mutations were identified in the EDARADD (n = 1), AXIN2 (n = 3), MSX1 (n = 2), and PAX9 (n = 4) genes, respectively. None of the 10 probands with mutations had other self-reported symptoms from ectodermal tissues. The oral parameters were similar when comparing individuals with and without mutations but a family history of oligodontia was three times more frequent for probands with mutations. EDARADD mutations have previously been reported in a few families segregating hypohidrotic ectodermal dysplasia and this is, to our knowledge, the first report of an EDARADD mutation associated with isolated oligodontia.

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“…EDs comprise a large heterogeneous group of genetic disorders with developmental abnormalities in two or more of the following ectodermal structures: teeth, skin, sweat glands, nails and hair. The salivary glands are ectodermal in origin, and reduced salivary secretion has been demonstrated in both ED and isolated oligodontia [4,5]. In these conditions, it is also common for present teeth to be peg-shaped.…”

Section: Introductionmentioning

confidence: 99%

Associations between ectodermal dysplasia, psychological distress and quality of life in a group of adults with oligodontia

Saltnes

Jensen

Saeves

et al. 2017

Acta Odontologica Scandinavica

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Objective: The aim of this study was to assess demographics, self-reported signs of ectodermal dysplasia (problems with hair, nails, skin and sweat glands), present teeth, previous dental treatment, psychological distress and QoL in individuals with oligodontia, and to explore the associations between these factors. We also aimed to compare the level of psychological distress and QoL between the study group and normative samples. Methods: Forty-seven individuals with oligodontia registered at a resource centre in Norway were included in the study. The participants completed self-administered questionnaires on demographics, ED signs, dental treatments, psychological distress and QoL (overall, health-related-and oral healthrelated QoL). Relevant statistics (independent t-test, correlation analysis and hierarchical multiple regressions) were used. Results: Thirty-five participants reported ED signs. Forty-one participants had tooth replacements (nine had removable dentures). Sixteen had 10 present teeth, 13 perceived dry mouth and seven were unemployed. Persons with 10 present teeth had higher anxiety-and depression-scores than those having >10 present teeth. Unemployment, dry mouth and removable dentures indicated poor healthrelated-and oral health related QoL. Compared to a normative sample; the study group had significantly poorer mental health (MH)-related QoL, mean (SD); (51.1(8.2) versus 46.8(9.3), p < .001) and more anxiety, mean (SD); (4.5(3.1) versus 6.7(3.6), p < .001). ED signs and treatments were most important for psychological distress and MH related QoL (MCS), whereas demographic parameters were most important for the other QoL measures. Conclusions: The psychological burden of oligodontia is significant, emphasizing the importance of a holistic approach by caregivers. ARTICLE HISTORY

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Signs and symptoms from ectodermal organs in young Swedish individuals with oligodontia

Cited by 33 publications

References 12 publications

Developmental Alterations of Teeth in Young Patients

Developmental Alterations of Teeth in Young Patients

Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes

Associations between ectodermal dysplasia, psychological distress and quality of life in a group of adults with oligodontia

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