Summary:given carefully planned dental prophylaxis including fluorides and chlorhexidine, no increase in prevalence of caries could be found. 3,5 Salivary function, dental caries and caries-associated salivary microorganisms were investigated in childrenThe aim of the present investigation was to study the effect of conditioning regimens used in bone marrow transundergoing BMT during a 4-year longitudinal study. Fourteen children were conditioned with CY and TBI plantation on salivary function, changes in caries-associated microflora and development of dental caries in children, and 12 with CY with or without BU. Four years after BMT the mean salivary secretion rate was 1.3 ± 0.7 during a 4-year longitudinal study. ml/min in the chemotherapy group, compared to 0.7 ± 0.5 in the TBI/CY group (P Ͻ 0.05). The mean salivary secretion rate fell from 0.9 ± 0.5 ml/min before Patients and methods TBI to 0.2 ± 0.1 after 3 months (P Ͻ 0.01), 0.3 ± 0.3 ml/min after 6 months (P Ͻ 0.01) and 0.5 ± 0.6, 1 year Patients after TBI (P Ͻ 0.05). Mean reduction in stimulated salivary flow 3 months after TBI was 78% in the TBI/CYThe study included 26 recipients of allogeneic BMT, grafted between August 1983 and May 1992. Children over group compared to 36% in the chemotherapy group (P Ͻ 0.05). Children conditioned with chemotherapy 4 years of age were considered able to cooperate to salivary sampling during the follow-up. A total of 56 children, 4 to showed an increased salivary flow compared to baseline; this was not found in TBI-treated children, suggesting 12 years of age were grafted during this period. Twentythree children died during the first year, three during the that damage to the salivary glands may be permanent. Four years after BMT, children conditioned with TBI second year and one child during the third year after BMT. Three children did not cooperate with the baseline salivary had significantly higher counts of mutans streptococci (P Ͻ 0.05) and lactobacilli (P Ͻ 0.01) compared to agesecretion test. The children were divided into two groups according to conditioning therapy: TBI/CY group (n = 14) matched controls. However, the prevalence of dental caries did not differ between children conditioned with and chemotherapy group (n = 12). Baseline characteristics of the children are presented in Table 1. TBI, chemotherapy and healthy controls. Keywords: bone marrow transplantation; children; dental Patients with hematological malignancies were treated with CY 60 mg/kg once daily i.v. on days 1 and 2 (total caries; mutans streptococci; total body irradiation dose 120 mg/kg) combined with 10 Gy TBI, delivered by a linear accelerator at a mean dose rate of 0.04 Gy/min, with the lungs shielded to receive no more than 9 Gy, or Advances in treatment of malignancy in childhood have BU 4 mg/kg p.o. in divided doses daily for 4 days in combiresulted in an increasing number of long-term survivors.nation with CY (total dose 120 mg/kg). 6,7 Patients with Apart from acute toxicity, conditioning regimens used in SAA received CY (200 mg/k...

BackgroundDrooling can be a severe disability and have high impact on daily life. Reversible treatment is preferable.AimTo analyse whether sublingual administration of atropine eyedrops is a useful reversible treatment option for severe drooling in children with disabilities.DesignThe study had a prospective, single‐system research design. The participants served as their own controls. The study period was 3 weeks without treatment, 4 weeks with atropine eyedrop solution 10 mg/mL one drop a day followed by 4 weeks of one drop twice a day. Parents’ rating of their child's drooling was assessed on a 100‐mm VAS, and unstimulated salivary secretion rate measurement was performed together with notations about side effects and practicality.ResultsParents’ VAS assessment of drooling decreased from a median (range) of 74 (40–98) at baseline to 48 (18–88) (P = 0.05) and 32 (12–85) (P = 0.004) after 4 weeks of atropine once a day and another 4 weeks of atropine twice a day, respectively (n = 11). Unstimulated salivary secretion rates decreased from baseline to end of study (P = 0.032). Several parents complained about difficult administration. No irreversible side effects were noted.ConclusionsSublingual atropine eyedrops may be an alternative for treatment of severe drooling in children with disabilities.

An early identification of individuals with oligodontia can be made in a majority of cases by checking that all permanent incisors have erupted at the age of 8 years. The validity in asking individuals about normal and abnormal function of ectodermal organs was found to be low. This indicates that there is a strong need to establish routine clinical criteria for dysplasia of ectodermal organs.

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Eighty-seven per cent of the participants with PWS demonstrated dysfunction in two or more domains, particularly in the domains Oral motor function, Habits and Face at rest.