Signs of reperfusion injury following CO2 pneumoperitoneum: an in vivo microscopy study

Nickkholgh, Arash; Barro-Bejarano, Miriam; Liang, Rui; Zorn, Markus; Mehrabi, Arianeb; Gebhard, Martha-Maria; Büchler, Markus W.; Gutt, Carsten N.; Schemmer, Peter

doi:10.1007/s00464-007-9386-6

Cited by 49 publications

(50 citation statements)

References 67 publications

(67 reference statements)

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“…A study by Nickkholgh et al demonstrated that pneumoperitoneum at 12 mmHg for 90 minutes induced histological (in vivo light microscopy) and biochemical (plasma liver enzyme levels) evidence of liver reperfusion injury in rats. 10 A significant increase in oxidative stress (MDA, protein carbonyls) was also observed in a rat model of laparoscopic donor nephrectomy. 33 Extra-abdominal organs also demonstrate oxidative stress with pneumoperitoneum, such as significantly increased MDA levels in rat lungs 2 and 6 h after deflation.…”

Section: Discussionmentioning

confidence: 91%

“…7,30,35 Pneumoperitoneum performed in rats with a pressure of 5, 10 or 15 mmHg resulted in an incremental increase in the formation of free oxygen radicals in lung and liver tissues. 36 In the study by Nickkholgh and colleagues, 10 histological and biochemical evidence of liver reperfusion injury was demonstrable at 12 mmHg but not at 8 mmHg.…”

Section: Discussionmentioning

confidence: 96%

“…8,9 These findings have led to the hypothesis that abdominal insufflation and consequently raised intra-abdominal pressure may produce significant organ ischemia, followed by reperfusion injury upon deflation of the abdomen. 10 One of the main consequences of ischemia-reperfusion injury is an imbalance between oxidants and antioxidants causing oxidative stress. 10 Volatile anesthetics used in laparoscopic surgery can also augment the release of inflammatory mediators and free radicals.…”

mentioning

confidence: 99%

“…10 One of the main consequences of ischemia-reperfusion injury is an imbalance between oxidants and antioxidants causing oxidative stress. 10 Volatile anesthetics used in laparoscopic surgery can also augment the release of inflammatory mediators and free radicals. Thus, general anesthesia (i.e., volatile anesthetics) may impair immunologic defense mechanisms inducing an inflammatory reaction in the macrophages.…”

mentioning

confidence: 99%

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Impact of Volatile Anesthetics on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy for Gallstones

Yalçın¹,

Aydoğan²,

Serdaroğlu³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : This study aimed to investigate the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and the paraoxonase and arylesterase activities of patients with gallstones and compare them with healthy individuals as well as to assess the impact of sevoflurane and desflurane on oxidative stress markers in laparoscopic surgery. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Forty patients scheduled for laparoscopic surgery (Patient Group) and 30 healthy volunteers as control subjects (Control Group) were enrolled in the study. The patient group was randomized to desflurane group (n= 0) and sevoflurane group (n= 20). Blood samples were collected preoperatively and at postoperative 6 hours in order to measure the levels of TAS, TOS, OSI, and paraoxonase and arylesterase activities. Preoperative and postoperative laboratory findings of sevoflurane and desflurane group were compared with the Mann Whitney U test between groups and the Wilcoxon test within a group. R Re es su ul lt ts s: : Preoperative TOS, OSI levels in the patient group were significantly increased and arylesterase activities were significantly decreased compared to the control group (p<0.05) [(TOS (µmol H2O2 equiv/L), 19.64 ± 2.16 vs. 14.25 ± 1.83), (OSI 1.85 ± 0.53 vs. 0.98 ± 0.24), (Arylesterase (U/L), 45.19 ± 6.82 vs. 49.66 ± 4.78)]. There was no statistically significant difference between sevoflurane and desflurane group in laboratory findings of the preoperative and the postoperative period (p> 0.05). Preoperative and postoperative TAS, TOS, OSI results and activities of paraoxonase and arylesterase were not significantly different in the sevoflurane group (p> 0.05). Although the preoperative and postoperative levels of TAS and TOS and paraoxonase and arylesterase activities in the desflurane group was not significantly different, postoperative OSI was significantly increased (p< 0.05) (OSI 1.80 ± 0.57 vs 2.20 ± 0.67). C Co on nc cl lu us si io on n: : Patients with gallstone are exposed to a potent oxidative stress influencing TOS, OSI levels and arylesterase activities. Sevoflurane and desflurane had similar effects on oxidative stress during laporoscopic surgery in this patient group; however, OSI was increased in the desflurane group in the postoperative period compared to preoperative levels (p< 0.05).K Ke ey y W Wo or rd ds s: : Gallstones; laparoscopy; sevoflurane; desflurane; oxidative stress Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmada, safra taşı olan hastalarda total oksidan seviye (TOS), total antioksidan seviye (TAS), oksidatif stres indeksi (OSİ) seviyelerinin ve paraoksonaz, arilesteraz aktivitelerinin, sağlıklı bireylerdeki parametrelerle karşılaştırılması ve laparoskopik cerrahide oluşan oksidatif stres üzerinde sevofluran ve desfluranın etkilerinin araştırılması amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Laparoskopik cerrahi planlanan 40 hasta (hasta grubu) ve 30 sağlıklı gönüllü (kontrol grubu) çalışmaya dâhil...

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Impact of Volatile Anesthetics on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy for Gallstones

Yalçın¹,

Aydoğan²,

Serdaroğlu³

et al. 2012

Turkiye Klinikleri J Med Sci

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“…Many studies have focused on changes in blood ow in intra-and extra-peritoneal organs, which is reduced during operation but is normalized a er desu ation [5][6][7]. is ischemia/reperfusion e ect leads to the overproduction of oxidants or the malfunction of the scavenging systems, postoperatively; even causing cellular damage and resultant organ dysfunction [8,9,10].…”

mentioning

confidence: 99%

Low-dose ketamine pretreatment reduces oxidative damage and inflammatory response following CO2 pneumoperitoneum in rats

Xu¹,

Gào²,

Peng³

et al. 2014

CIM

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Low-dose ketamine pretreatment reduces oxidative damage and in ammatory response following CO2 pneumoperitoneum in rats AbstractPurpose: e duration of pneumoperitoneum during laparoscopic procedures may contribute to post-surgical oxidative stress. Previous studies have shown that low-dose ketamine, an anesthetic with anti-in ammatory properties, protects various organs from ischemia-reperfusion injury. is study investigated the e ects of low-dose ketamine on the overproduction of oxidants and the tissue damage caused by intra-abdominal pressure during CO2 pneumoperitoneum.Methods: Male Sprague Dawley rats received a CO2 pneumoperitoneum of 15 mmHg and preceded by either low-dose ketamine (KP1, 5 mg/kg; KP2, 10 mg/kg) or 0.9% saline (PR, 3 ml). General anethesia was provided by pentobarbital and sevo urane. e control group (CR) received an intraperitoneal saline injection and sham surgery. ree hours a er pneumoperitoneum, serum concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), superoxide dismutase (SOD) and intestinal fatty acid binding protein (iFABP) were measured and liver, kidney, lung, and intestine were evaluated for tissue damage.Results: e highest plasma MDA, TNF-α, IL-6 and iFABP values were observed at T1 (a er 3 hours of pneumoperitoneum) in the PR group, followed by the KP1, KP2, and CR groups (P < 0.01). SOD concentrations showed an opposite trend and were highest in the CR group, followed by the KP2, KP1, and PR groups (P < 0.01). TNF-α concentration was signi cantly lower in the KP2 than the KP1 group (P < 0.05). Histopathologic scoring of organ sections demonstrated the lowest scores in the KP2 group, followed by the KP1 and PR groups, in an increasing order (P < 0.05).Conclusion: Pretreatment with low-dose ketamine before general anaesthesia protects against potential oxidative damage and in ammatory response caused by CO2 pneumoperitoneum.

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Laparoscopic Contraindications, Complications, and Conversion

Buote¹,

McClaran²

2015

Small Animal Laparoscopy and Thoracoscopy

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Signs of reperfusion injury following CO2 pneumoperitoneum: an in vivo microscopy study

Cited by 49 publications

References 67 publications

Impact of Volatile Anesthetics on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy for Gallstones

Impact of Volatile Anesthetics on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy for Gallstones

Low-dose ketamine pretreatment reduces oxidative damage and inflammatory response following CO2 pneumoperitoneum in rats

Laparoscopic Contraindications, Complications, and Conversion

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