SIKVAV-Modified Chitosan Hydrogel as a Skin Substitutes for Wound Closure in Mice

Chen, Xionglin; Cao, Xiaoming; Che, Xiangxin; Xu, Xiaoyuan; Ma, Baicheng; Zhang, Jie; Huang, Tao

doi:10.3390/molecules23102611

Cited by 34 publications

(24 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rarely, an endothelial layer was complete. The loss of endothelial cells may expose the extracellular matrix, which obviously sets various pathological processes in motion [23][24][25][26]. The increased activation of matrix metalloproteinases in pathologically altered human cardiac valves emphasizes the crucial role of the extracellular matrix in the development of this disease [26].…”

Section: Discussionmentioning

confidence: 99%

Evidence of woven bone formation in carotid artery plaques

Mirzaie¹,

Guliyev²,

Schultz³

et al. 2021

J Cardiol Cardiovasc Med

View full text Add to dashboard Cite

Objective: Plaque morphology plays an important prognostic role in the occurrence of cerebrovascular events. Echolucent and heterogeneous plaques, in particular, carry an increased risk of subsequent stroke. Depending on the quality of the plaque echogenicity based on B-mode ultrasound examination, carotid plaques divide into a soft lipid-rich plaque and a hard plaque with calcification. The aim of this study was to investigate structural changes in the basement membrane of different carotid artery plaque types. Patients and methods: Biopsies were taken from 10 male patients (average age; 75 + 1 years) and 7 females (68 + 3 years). The study population included patients suffering from a filiform stenosis of the carotid artery, 8 patients with acute cerebrovascular events and 9 with asymptomatic stenosis. Scanning electron and polarised light microscopic investigations were carried out on explanted plaques to determine the morphology of calcified areas in vascular lesions. Results: By means of scanning electron microscopy, multiple foci of local calcification were identified. The endothelial layer was partially desquamated from the basement membrane and showed island-like formations. Polarised light microscopy allows us to distinguish between soft plaques with transparent structure and hard plaques with woven bone formation. Conclusion: The major finding of our study is the presence of woven bone tissue in hard plaques of carotid arteries, which may result from pathological strains or mechanical overloading of the collagen fibers. These data suggest a certain parallel with sclerosis of human aortic valves due to their similar morphological characteristics.

show abstract

Section: Discussionmentioning

confidence: 99%

Evidence of woven bone formation in carotid artery plaques

Mirzaie¹,

Guliyev²,

Schultz³

et al. 2021

J Cardiol Cardiovasc Med

View full text Add to dashboard Cite

show abstract

“…Controlled anticancer drug release [142] Tumor targeted therapy [143] N-octyl-O-sulfate chitosan Self-assembled polymeric micelles Absorption enhancement of anticancer drug [144,145] Tumor targeted therapy [146][147][148] Increasing stability of drug loaded liposomes [149] 2-[phenylhydrazine (or hydrazine)-thiosemicarbazone]-chitosan Powder Pharmaceutical and food industries [150] (Ser-Ile-Lys-Val-Ala-Val) peptide-modified chitosan Hydrogel Skin substitutes for wound closure in mice [53,151] Galactosylated chitosan (GC) NPs Tumor targeted therapy [152][153][154][155] siRNA delivery [156,157] N-palmitoyl chitosan (NPCS) MPs and micelles Tumor targeted therapy [158,159] O-palmitoyl chitosan (OPC) Liposomes Intestinal drug delivery [160] Hydroxyapatite/CS NPs Drug delivery [161][162][163][164] CS loaded with antioxidant NPs Hydrogel Drug release [165] PEGylated CS NPs Tumor targeted therapy [166][167][168] Chitosan-based vaccine Polyelectrolyte, NPs Intranasal CS-DNA vaccine [169,170] 4. Conclusions CS, as a natural polymer, is actively used in tissue engineering and regenerative medicine as a biomaterial alone, as well as in combination with other polymers.…”

Section: Cs/derivativesmentioning

confidence: 99%

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

et al. 2019

View full text Add to dashboard Cite

Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent biodegradability, biocompatibility, and antimicrobial activity. Due to the presence of free amine groups in its backbone chain, chitosan could be further chemically modified to possess additional functional properties useful for the development of different biomaterials in regenerative medicine. In the current review, we will highlight the progress made in the development of chitosan-containing bioscaffolds, such as gels, sponges, films, and fibers, and their possible applications in tissue repair and regeneration, as well as the use of chitosan as a component for drug delivery applications.

show abstract

“…Then, the specimens were embedded in paraffin blocks and a microtome (Leica Biosystems, Germany) was employed to obtain multiple sections with 4 µm thickness. The tissue sections were stained by Hematoxylin & Eosin (H&E) 34 and Masson's trichrome 35 methods, separately. The mounted slides were observed by a digital light microscope which was equipped with an Olympus DP70 digital camera (Olympus, Japan).…”

Section: Animal Model and Histological Evaluationmentioning

confidence: 99%

“…Also, the specimens were stained with Masson's trichrome to analysis collagen deposition. Collagen deposition at the wound matrix plays a critical role in the healing process, as it provides scaffolds for wound-healing cells 35 . More accumulation of collagen fibers and collagen deposition was observed in the PU/EEP-PCL/Gel group's specimens in comparison with the PU/EEP membrane and Ctrl.…”

Section: Hydrolytic and Enzymatic Degradation Hydrolytic Degradationmentioning

confidence: 99%

A Novel Bilayer Wound Dressing Composed of a Dense Polyurethane/Propolis Membrane and a Biodegradable Polycaprolactone/Gelatin Nanofibrous Scaffold

Eskandarinia

Kefayat

Agheb

et al. 2020

Sci Rep

155

View full text Add to dashboard Cite

one-layer wound dressings cannot meet all the clinical needs due to their individual characteristics and shortcomings. Therefore, bilayer wound dressings which are composed of two layers with different properties have gained lots of attention. in the present study, polycaprolactone/gelatin (pcL/Gel) scaffold was electrospun on a dense membrane composed of polyurethane and ethanolic extract of propolis (pU/eep). the pU/eep membrane was used as the top layer to protect the wound area from external contamination and dehydration, while the PCL/Gel scaffold was used as the sublayer to facilitate cells' adhesion and proliferation. the bilayer wound dressing was investigated regarding its microstructure, mechanical properties, surface wettability, anti-bacterial activity, biodegradability, biocompatibility, and its efficacy in the animal wound model and histopathological analyzes. Scanning electron micrographs exhibited uniform morphology and bead-free structure of the PCL/Gel scaffold with average fibers' diameter of 237.3 ± 65.1 nm. Significant anti-bacterial activity was observed against Staphylococcal aureus (5.4 ± 0.3 mm), Escherichia coli (1.9 ± 0.4 mm) and Staphylococcus epidermidis (1.0 ± 0.2 mm) according to inhibition zone test. The bilayer wound dressing exhibited high hydrophilicity (51.1 ± 4.9°), biodegradability, and biocompatibility. The bilayer wound dressing could significantly accelerate the wound closure and collagen deposition in the Wistar rats' skin wound model. taking together, the pU/eep-pcL/Gel bilayer wound dressing can be a potential candidate for biomedical applications due to remarkable mechanical properties, biocompatibility, antibacterial features, and wound healing activities. Skin is always at the exposer of different types of damages 1. Severe skin damages can be life-threatening due to loss of human body fluids, electrolytes, and nutritional components from the wound area. Therefore, wound dressings have gained lots of attention 2. An ideal wound dressing should protect the wound from external contaminants and facilitate the healing process. However, one-layer wound dressings cannot meet all the clinical needs due to their individual characteristics and shortcomings. Therefore, bilayer wound dressings which are

show abstract

SIKVAV-Modified Chitosan Hydrogel as a Skin Substitutes for Wound Closure in Mice

Cited by 34 publications

References 30 publications

Evidence of woven bone formation in carotid artery plaques

Evidence of woven bone formation in carotid artery plaques

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

A Novel Bilayer Wound Dressing Composed of a Dense Polyurethane/Propolis Membrane and a Biodegradable Polycaprolactone/Gelatin Nanofibrous Scaffold

Contact Info

Product

Resources

About