This paper presents an approach to reduce substrate cross-talk noise between noisy and sensitive circuitry in mixed-signal integrated circuits at different stages of design and layout development. Silencer! a new, fully automated, schematic-driven substrate noise coupling analysis tool is introduced to accomplish this task. The tool seamlessly enables substrate noise coupling analysis in a standard mixed-signal design flow. Two different methods, fast scalable macro-models and a boundary element solver are integrated into Silencer!. These methods allow extractions of a substrate network from geometric layout information. Simulation results obtained with Silencer! are accurate to within 10% of measured integrated circuits.Index Terms-Coupling noise, integrated circuit noise, mixed-signal noise, noise analysis tool, noise minimization, pre-/post-layout analysis, substrate noise, substrate noise analysis, supply noise.