2021
DOI: 10.1080/08923973.2021.1966031
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Silencing lncRNA LINC01410 suppresses cell viability yet promotes apoptosis and sensitivity to temozolomide in glioblastoma cells by inactivating PTEN/AKT pathway via targeting miR-370-3p

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Cited by 14 publications
(5 citation statements)
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“…LINC01410 depletion stimulates apoptotic cell death and diminishes survival rate. LINC01410 suppresses miRNA-370–3p to down-regulate PTEN, causing Akt-mediated tumorigenesis [ 94 ].…”
Section: Lncrnas In Proliferation and Invasionmentioning
confidence: 99%
“…LINC01410 depletion stimulates apoptotic cell death and diminishes survival rate. LINC01410 suppresses miRNA-370–3p to down-regulate PTEN, causing Akt-mediated tumorigenesis [ 94 ].…”
Section: Lncrnas In Proliferation and Invasionmentioning
confidence: 99%
“…A literature search revealed various lncRNAs affecting TMZ resistance in glioma, as well as their functions and targets ( 62 - 82 ). This list of lncRNAs is presented in Table I .…”
Section: Oncogenic Lncrnas Promote Tmz Resistance In Gliomasmentioning
confidence: 99%
“…Inhibition of miR-370-3p reversed the effects of LINC01410 silencing on the malignant biological behavior of GBM cells. Based on these findings, LINC01410 was concluded to promote glioma growth and TMZ resistance by sponging miR-370-3p to inhibit the PTEN/AKT pathway ( 62 ).…”
Section: Oncogenic Lncrnas Promote Tmz Resistance In Gliomasmentioning
confidence: 99%
“…ROR1-AS1 inhibition triggers apoptosis in lung cancer cells by dephosphorylating AKT [47]. LINC01410 and lncRNA PITPNA-AS1 are overexpressed in glioblastoma cells [48,49]. LINC01410 knockdown induces temozolomide-induced apoptosis of glioblastoma cells by upregulating PTEN expression and dephosphorylating AKT [48].…”
Section: Apoptosis By Akt-regulating Lncrnasmentioning
confidence: 99%
“…LINC01410 and lncRNA PITPNA-AS1 are overexpressed in glioblastoma cells [48,49]. LINC01410 knockdown induces temozolomide-induced apoptosis of glioblastoma cells by upregulating PTEN expression and dephosphorylating AKT [48]. LncRNA PITPNA-AS1 inhibits apoptosis of glioblastoma cells by upregulating epidermal growth factor receptor (EGFR) expression and phosphorylating AKT [49].…”
Section: Apoptosis By Akt-regulating Lncrnasmentioning
confidence: 99%