2019
DOI: 10.1002/jcb.29206
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Silencing of long noncoding RNA HOXD‐AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway

Abstract: Accumulating findings reveal that long noncoding RNAs (lncRNAs) as crucial regulatory molecules serve vital functions in the progression of hepatocellular carcinoma (HCC). This study aims to investigate the biological roles and mechanisms of lncRNA HOXD cluster antisense RNA 1 (HOXD‐AS1) in HCC cells based on transcriptome analysis. The Cancer Genome Atlas data analysis and experimental validation showed that HOXD‐AS1 was increased in HCC tissues/cell lines and positively relevant to histologic grade. The subc… Show more

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Cited by 23 publications
(23 citation statements)
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“…Accumulating studies have also confirmed that migration and invasion of HCC were crucial in the prognosis of patients with HCC 36,37 . The previous report also revealed that lncRNAs, such as HOXD‐AS1 and EIF3J‐AS1 , play a role in migration and invasion of HCC 38,39 . Consistently, our result also revealed that H19 expression was associated with invasion in MHCC97H cells.…”
Section: Discussionsupporting
confidence: 88%
“…Accumulating studies have also confirmed that migration and invasion of HCC were crucial in the prognosis of patients with HCC 36,37 . The previous report also revealed that lncRNAs, such as HOXD‐AS1 and EIF3J‐AS1 , play a role in migration and invasion of HCC 38,39 . Consistently, our result also revealed that H19 expression was associated with invasion in MHCC97H cells.…”
Section: Discussionsupporting
confidence: 88%
“…mRNAs, miRNAs, lncRNAs and circRNAs affect the occurrence and development of cancer by regulating the activation of ERK signaling pathway. It is reported that lncRNA HOXD-AS1 influences the proliferation and invasion of hepatocellular carcinoma cells by regulating the activation of ERK signaling pathway [20]; miR-98 inhibits cell growth and invasion in retinoblastoma by targeting ERK signaling Pathway [21]; cicrRNA_006528 promotes the occurrence and development of breast cancer by activating ERK signaling pathway [22]; ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7) inhibit the proliferation of lung cancer by inhibiting the activation of ERK signaling pathway [19]. Our previous studies have shown that CLDN8 promotes the proliferation and metastasis of colon cancer cells by activating MAPK/ERK signaling pathway [23].…”
Section: Introductionmentioning
confidence: 99%
“…23 However, no direct evidence supports the role of PME-1 in tumor cell migration and invasion. Given the versatility of the critical role of ERK and GSK-3β pathway in HCC tumorigenesis, 24,25 we speculate that the tumor promotor role of PME-1 in HCC can be ascribed to this mechanism, and more studies are necessary to clarify this speculation in the future work.…”
Section: Discussionmentioning
confidence: 94%