Silent myocardial ischemia in diabetic and nondiabetic patients with coronary artery disease

Falcone, Colomba; Nespoli, Luigi; Geroldi, Diego; Gazzaruso, Carmine; Buzzi, Maria Paola; Auguadro, Carla; Tavazzi, Luigi; Schwartz, Peter J.

doi:10.1016/s0167-5273(02)00558-2

Cited by 37 publications

(25 citation statements)

References 49 publications

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“…Diabetic patients mostly have been shown to have a higher incidence of silent ischemia than nondiabetic patients. 19 -21 One study, however, by Falcone et al 22 found equivalent rates of ischemia during exercise ECG testing in the absence of angina (58% versus 64%, PϭNS). However, only patients with documented CAD by angiography were included, and those with neuropathy and retinopathy were excluded.…”

Section: Silent Ischemia and Diabetesmentioning

confidence: 99%

Stress Testing in Patients With Diabetes Mellitus

2006

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Section: Silent Ischemia and Diabetesmentioning

confidence: 99%

Stress Testing in Patients With Diabetes Mellitus

2006

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“…This is of major public health importance since patients with type 2 diabetes are at increased risk of developing and dying from cardiovascular disease, which accounts for up to 70% of deaths in this population [2]. The epidemiology and characteristics of coronary artery disease in type 2 diabetes are well described in the literature [3][4][5][6][7]. The focus in reducing cardiovascular deaths in diabetes tends almost exclusively to be on reducing fresh coronary events.…”

Section: Introductionmentioning

confidence: 99%

The epidemiology of left ventricular hypertrophy in type 2 diabetes mellitus

2005

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Aims/hypothesis: Patients with type 2 diabetes mellitus are at greater cardiovascular risk than the general population. Although it is widely acknowledged that diabetes is a risk factor for coronary artery disease, the increased prevalence of potentially lethal left ventricular abnormalities in this population is less well appreciated. Methods: We carried out an echocardiographic study of 500 subjects with type 2 diabetes mellitus to assess the prevalence of left ventricular hypertrophy (LVH) and left ventricular systolic dysfunction (LVSD). We also assessed whether abnormalities in diastolic filling parameters were present. Results: Of the 371 patients in whom left ventricular mass could be successfully assessed, 264 had LVH (71%). Left ventricular systolic dysfunction was much less common, being present in 16/385 patients (4.2%). Long axis contraction was abnormal in 29/429 patients (6.8%). Diastolic filling abnormalities were present in 178/435 (41%) of patients who could be classified using the selected criteria. Conclusions: We conclude that left ventricular abnormalities are common in type 2 diabetic patients. As medical therapy is available for both LVH and LVSD and has been demonstrated to reduce cardiovascular death, these left ventricular abnormalities could be ideal targets for screening, followed by selective therapeutic intervention.

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“…9,10) Moreover, diabetes mellitus and hypercholesterolemia were implicated as risk factors, but there is no direct evidence that either of these factors can adequately explain the increased vulnerability to coronary heart disease. 11,12) Although, coronary heart disease is the leading cause of death in developed countries, developing countries such as Jordan has noticed an increase in deaths related to coronary heart disease. Risk factors such as obesity, smoking, low physical activities and unhealthy life style have been observed in Jordan.…”

Section: Introductionmentioning

confidence: 99%

The Association of Blood Biochemical Parameters with Myocardial Infarction

Nusier

El-Akawi

Otoom

2004

JOURNAL OF HEALTH SCIENCE

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Biochemical changes that occurred in the blood of myocardial infarction patients were investigated. Two hundred and fifty two patient, 180 males and 72 females were involved in this study. The mean age was 49.3 ± 9.25 years. Biochemical parameters including serum total protein, albumin, total bilirubin, and total cholesterol to albumin ratio were analyzed. Biochemical parameters showed that the increased level of triglyceride and total bilirubin were associated with myocardial infarction. Triglyceride and total bilirubin levels in myocardial infarction patients were 2.3 ± 1.4 mmol/l and 12.3 ± 3.2 mol/l respectively, whereas those of healthy controls were 1.7 ± 1.2 mmol/l for triglyceride and 9.7 ± 3.7 mol/l for bilirubin. On the other hand, serum total protein and albumin concentrations were lower in myocardial infarction patients compared with those of controls. Total protein level was 65.5 ± 3.1 g/l in myocardial infarction patients and 76.2 ± 5.3 g/l in healthy controls. Albumin levels in both patients and controls were 40.2 ± 3.2 g/l and 45.4 ± 4.5 g/l correspondingly. Interestingly, serum total cholesterol level was not significantly different in myocardial infarction patients compared with controls. Patients cholesterol level was 5.8 ± 1.3 mmol/l and that of controls was 5.2 ± 1.2 mmol/l. In addition, cholesterol/albumin ratio in infarction patients (0.14 ± 0.04) found to be significantly higher than that in healthy controls (0.11 ± 0.03).

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Silent myocardial ischemia in diabetic and nondiabetic patients with coronary artery disease

Cited by 37 publications

References 49 publications

Stress Testing in Patients With Diabetes Mellitus

Stress Testing in Patients With Diabetes Mellitus

The epidemiology of left ventricular hypertrophy in type 2 diabetes mellitus

The Association of Blood Biochemical Parameters with Myocardial Infarction

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