Silibinin releasing mesoporous bioactive glass nanoparticles with potential for breast cancer therapy

Nawaz, Qaisar; Fuentes-Chandía, Miguel; Tharmalingam, Varun; Rehman, Muhammad Atiq Ur; Leal‐Egaña, Aldo; Boccaccını, Aldo R.

doi:10.1016/j.ceramint.2020.08.083

Cited by 32 publications

(19 citation statements)

References 57 publications

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“…Relatively high porosity in the synthesized MBGNs is responsible for the high surface area [35]. This porous nature opens up other biomedical applications such as drug delivery and microbial cell encapsulation [26].…”

Section: Morphological Characterizationmentioning

confidence: 98%

“…On the other hand, mesoporous silica have pores in the range of 2 -50 nm which increase the surface area, and serve as a channel for adsorption/desorption of drugs for targeted drug delivery system [20][21][22]. Moreover, the therapeutic release of antibacterial and bioactive ions is anticipated to inhibit biofilm formation and resultant agony from infection, which is the main objective of this research work [21,[23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Silver–Strontium (Ag-Sr) Doped Mesoporous Bioactive Glass Nanoparticles

Bano¹,

Akhtar²,

Yasir³

et al. 2021

Preprint

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Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc. are increasing globally. Mesoporous bioactive glass nanoparticles (MBGNs) are used in biomedical devices due to their osteointegration and bioactive properties. In this study, silver (Ag) and strontium (Sr) doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were prepared by a modified Stöber process. In this method, Ag+ & Sr2+ were co-substituted in pure MBGNs to harvest the antibacterial properties of Ag ions, as well as pro-osteogenic potential of Sr2 ions. The effect of the two ion concentration on morphology, surface charge, composition, antibacterial ability, and in-vitro bioactivity was studied. Scanning electron microscopy (SEM), X-Ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) confirmed the doping of Sr and Ag in MBGNs. SEM and EDX analysis confirmed the spherical morphology and typical composition of MBGNs, respectively. The Ag-Sr MBGNs showed a strong antibacterial effect against Staphylococcus carnosus and Escherichia coli bacteria determined via turbidity and disc diffusion method. Moreover, the synthesized Ag-Sr MBGNs develop apatite-like crystals upon immersion in simulated body fluid (SBF), which suggested that the addition of Sr improved in-vitro bioactivity. The Ag-Sr MBGNs synthesize in this study can be used for the preparation of scaffolds or as a filler material in the composite coatings for bone tissue engineering.

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Section: Morphological Characterizationmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Silver–Strontium (Ag-Sr) Doped Mesoporous Bioactive Glass Nanoparticles

Bano¹,

Akhtar²,

Yasir³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, Ag-doped MBGNs are potential building blocks for preparing orthopedic implants. Bari et al studied MBGNs with admirable textural properties, in vitro bioactivity, and excellent antibacterial properties against different bacteria [20,[22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

“…Relatively high porosity in the synthesized MBGNs may lead to the high surface area[29]. This porous nature opens up other biomedical applications such as drug delivery and microbial cell encapsulation[25].…”

mentioning

confidence: 99%

Synthesis and Characterization of Silver–Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles

Bano

Akhtar

Yasir

et al. 2021

Gels

Self Cite

View full text Add to dashboard Cite

Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc., are increasing globally. Mesoporous bioactive glass nanoparticles (MBGNs) are used in biomedical devices due to their osteointegration and bioactive properties. In this study, silver (Ag)- and strontium (Sr)-doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were prepared by a modified Stöber process. In this method, Ag+ and Sr2+ were co-substituted in pure MBGNs to harvest the antibacterial properties of Ag ions, as well as pro-osteogenic potential of Sr2 ions. The effect of the two-ion concentration on morphology, surface charge, composition, antibacterial ability, and in-vitro bioactivity was studied. Scanning electron microscopy (SEM), X-Ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) confirmed the doping of Sr and Ag in MBGNs. SEM and EDX analysis confirmed the spherical morphology and typical composition of MBGNs, respectively. The Ag-Sr MBGNs showed a strong antibacterial effect against Staphylococcus carnosus and Escherichia coli bacteria determined via turbidity and disc diffusion method. Moreover, the synthesized Ag-Sr MBGNs develop apatite-like crystals upon immersion in simulated body fluid (SBF), which suggested that the addition of Sr improved in vitro bioactivity. The Ag-Sr MBGNs synthesized in this study can be used for the preparation of scaffolds or as a filler material in the composite coatings for bone tissue engineering.

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“…Influencing molecules, such as phenol derivatives, amino acids and flavonoids, can improve SBN's bioavailability [14]. To overcome these limitations and to mitigate the unfavorable pharmacokinetic profile, different nanoparticle-based drug delivery approaches are being developed to improve SBN bioavailability [15,16]. Systems based on polymeric nanoparticles demonstrate long-term stability, improved effectiveness, non-toxicity, and targeted drug release in comparison with traditional carriers [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

PEG-Modified tert-Octylcalix[8]arenes as Drug Delivery Nanocarriers of Silibinin

et al. 2021

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The hepatoprotective properties of silibinin, as well its therapeutic potential as an anticancer and chemo-preventive agent, have failed to progress towards clinical development and commercialization due to this material’s unfavorable pharmacokinetics and physicochemical properties, low aqueous solubility, and chemical instability. The present contribution is focused on the feasibility of using PEGylated calixarene, in particular polyoxyethylene-derivatized tert-octylcalix[8]arene, to prepare various platforms for the delivery of silibinin, such as inclusion complexes and supramolecular aggregates thereof. The inclusion complex is characterized by various instrumental methods. At concentrations exceeding the critical micellization concentration of PEGylated calixarene, the tremendous solubility increment of silibinin is attributed to the additional solubilization and hydrophobic non-covalent interactions of the drug with supramolecular aggregates. PEG-modified tert-octylcalix[8]arenes, used as drug delivery carriers for silibinin, were additionally investigated for cytotoxicity against human tumor cell lines.

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Silibinin releasing mesoporous bioactive glass nanoparticles with potential for breast cancer therapy

Cited by 32 publications

References 57 publications

Synthesis and Characterization of Silver–Strontium (Ag-Sr) Doped Mesoporous Bioactive Glass Nanoparticles

Synthesis and Characterization of Silver–Strontium (Ag-Sr) Doped Mesoporous Bioactive Glass Nanoparticles

Synthesis and Characterization of Silver–Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles

PEG-Modified tert-Octylcalix[8]arenes as Drug Delivery Nanocarriers of Silibinin

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