Silica Nanospheres: Hollow Structure Improved Anti-Cancer Immunity of Mesoporous Silica Nanospheres In Vivo (Small 26/2016)

Wang, Xiupeng; Li, Xia; Ito, Atsuo; Yoshiyuki, Kazuko; Sogo, Yu; Watanabe, Yohei; Yamazaki, Atsushi; Ohno, Tadao; Tsuji, Noriko M.

doi:10.1002/smll.201670129

Cited by 10 publications

(4 citation statements)

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“…MSNs present a number of excellent material properties, such as good in vitro and in vivo biocompatibility, chemical and mechanical stability, and easy functionalization ability . In fact, the favorable structural features of MSNs, such as intrinsic tunable pore size, high pore volume, and high surface area, could guarantee an extraordinary drug loading capacity and high encapsulation efficiency of a wide variety of cargo molecules . Additionally, their surfaces can be functionalized with “gate keepers,” some of which are highly sensitive to a variety of exogenous and endogenous stimuli, such as light, pH, temperature, and remote magnetic actuation, enabling controlled and on‐command release of the cargo …”

Section: Introductionmentioning

confidence: 99%

TPGS‐Functionalized Polydopamine‐Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance

Cheng

Liang

et al. 2017

Small

240

118

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A nanocarrier system of d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized polydopamine-coated mesoporous silica nanoparticles (NPs) is developed for sustainable and pH-responsive delivery of doxorubicin (DOX) as a model drug for the treatment of drug-resistant nonsmall cell lung cancer. Such nanoparticles are of desired particle size, drug loading, and drug release profile. The surface morphology, surface charge, and surface chemical properties are also successfully characterized by a series of techniques such as transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) method, thermal gravimetric analysis (TGA), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR). The normal A549 cells and drug-resistant A549 cells are employed to access the cytotoxicity and cellular uptake of the NPs. The therapeutic effects of TPGS-conjugated nanoparticles are evaluated in vitro and in vivo. Compared with free DOX and DOX-loaded NPs without TPGS ligand modification, MSNs-DOX@PDA-TPGS exhibits outstanding capacity to overcome multidrug resistance and shows better in vivo therapeutic efficacy. This splendid drug delivery platform can also be sued to deliver other hydrophilic and hydrophobic drugs.

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Section: Introductionmentioning

confidence: 99%

TPGS‐Functionalized Polydopamine‐Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance

Cheng

Liang

et al. 2017

Small

240

118

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“…Based on the extensive porous network, high specific surface area and excellent biocompatibility, mesoporous silica has emerged as a common drug carrier [27,28,29,30,31]. When mesoporous silica is incorporated in cellulose membrane, hierarchic pore structure will be attained inside the mesoporous matrix of the cellulose–silica membranes.…”

Section: Introductionmentioning

confidence: 99%

Engineering Sustainable Antimicrobial Release in Silica-Cellulose Membrane with CaCO3-Aided Processing for Wound Dressing Application

et al. 2019

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The sustained release of antimicrobial therapeutics for wound dressing has become an attractive design strategy for prolonging the timespan of wound dressings and for reducing the risk of chronic wound infection. Recently, cellulose-based membrane has become a preferred option of wound dressings for the treatment of burn wounds and skin ulcers. In this work, novel cellulose membrane incorporated with mesoporous silica particles (SBA-15) was developed as an antimicrobial wound dressing with desirable sustained release functionality for targeting persistent bacterial pathogens. Attributed to a coated layer of calcium carbonate (CaCO3), SBA-15 particles were free from corrosion in alkaline condition during the preparation of cellulose-based composite membranes. SEM, TEM and BET results showed that the morphology, specific surface area, pore size and pore volume of pristine SBA-15 were preserved after the incorporation of CaCO3-coated SBA-15 into the cellulose matrix, while the mesoporous structure of SBA-15 was significantly disrupted without the use of CaCO3 coating. The resultant composite membranes containing 30 wt% SBA-15 (denoted as CM-Ca2-SBA(30%)) achieved 3.6 wt% of antimicrobial drug loading. Interestingly, CM-Ca2-SBA(30%) demonstrated the sustained release property of chloramphenicol for 270 h, driven by a two-stage drug release processes of SBA-15/cellulose. The water vapor permeability (WVTR) and swelling properties of composite membranes were shown to have complied with the primary requirements of wound dressing. Antibacterial assays revealed that strong antibacterial activities (144 h) of the composite membranes against Staphylococcus aureus and Eschericia coli were achieved. All results displayed that the strategy of coating silica with CaCO3 helps to obtain cellulose–silica composite membranes with desirable sustained release profiles and strong antibacterial activities. The antibacterial SBA-15/cellulose composite membranes show potential for the application of wound dressing.

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“…[ 13 ] Additionally, hollow MSNs were proven to increase the number of CD4 + and CD8 + T cells in spleen cells and promote antitumor immunity in vivo. [ 14 ] Some studies also have shown that MSNs can induce Th1 and Th2 immune responses, promote lymphocyte proliferation, and stimulate secretion of pro‐inflammatory cytokines, which is conducive to reverse the immunosuppressive tumor microenvironment (TME). [ 15 ] In short, MSNs are considered to be one of the most promising nanoadjuvant materials for various vaccine applications.…”

Section: Introductionmentioning

confidence: 99%

Effects of Skeleton Structure of Mesoporous Silica Nanoadjuvants on Cancer Immunotherapy

Tan,

Ding,

Chen

et al. 2023

Small

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Mesoporous silica nanoparticles (MSNs) have been widely praised as nanoadjuvants in vaccine/tumor immunotherapy thanks to their excellent biocompatibility, easy‐to‐modify surface, adjustable particle size, and remarkable immuno‐enhancing activity. However, the application of MSNs is still greatly limited by some severe challenges including the unclear and complicated relationships of structure and immune effect. Herein, three commonly used MSNs with different skeletons including MSN with tetrasulfide bonds (TMSN), MSN containing ethoxy framework (EMSN), and pure −Si−O−Si− framework of MSN (MSN) are comprehensively compared to study the impact of chemical construction on immune effect. The results fully demonstrate that the three MSNs have great promise in improving cellular immunity for tumor immunotherapy. Moreover, the TMSN performs better than the other two MSNs in antigen loading, cellular uptake, reactive oxygen species (ROS) generation, lymph node targeting, immune activation, and therapeutic efficiency. The findings provide a new paradigm for revealing the structure‐function relationship of mesoporous silica nanoadjuvants, paving the way for their future clinical application.

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Silica Nanospheres: Hollow Structure Improved Anti-Cancer Immunity of Mesoporous Silica Nanospheres In Vivo (Small 26/2016)

Cited by 10 publications

References 0 publications

TPGS‐Functionalized Polydopamine‐Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance

TPGS‐Functionalized Polydopamine‐Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance

Engineering Sustainable Antimicrobial Release in Silica-Cellulose Membrane with CaCO3-Aided Processing for Wound Dressing Application

Effects of Skeleton Structure of Mesoporous Silica Nanoadjuvants on Cancer Immunotherapy

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