Silicon electronics on silk as a path to bioresorbable, implantable devices

Kim, Dae‐Hyeong; Kim, Yun-Soung; Amsden, Jason J.; Panilaitis, Bruce; Kaplan, David L.; Omenetto, Fiorenzo G.; Zakin, M. R.; Rogers, John A.

doi:10.1063/1.3238552

Cited by 269 publications

(242 citation statements)

References 13 publications

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“…Silk films have been patterned with metal electrodes and intimately 'bioresorbed' onto brain and skin tissues for electro-mapping experiments 21,23 . Recent work has demonstrated the ability to fabricate active electronic components such as transistors 24 and metamaterials 25 on films of regenerated silk.…”

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confidence: 99%

Graphene-based wireless bacteria detection on tooth enamel

et al. 2012

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Direct interfacing of nanosensors onto biomaterials could impact health quality monitoring and adaptive threat detection. Graphene is capable of highly sensitive analyte detection due to its nanoscale nature. Here we show that graphene can be printed onto water-soluble silk. This in turn permits intimate biotransfer of graphene nanosensors onto biomaterials, including tooth enamel. The result is a fully biointerfaced sensing platform, which can be tuned to detect target analytes. For example, via self-assembly of antimicrobial peptides onto graphene, we show bioselective detection of bacteria at single-cell levels. Incorporation of a resonant coil eliminates the need for onboard power and external connections. Combining these elements yields two-tiered interfacing of peptide-graphene nanosensors with biomaterials. In particular, we demonstrate integration onto a tooth for remote monitoring of respiration and bacteria detection in saliva. overall, this strategy of interfacing graphene nanosensors with biomaterials represents a versatile approach for ubiquitous detection of biochemical targets.

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Graphene-based wireless bacteria detection on tooth enamel

et al. 2012

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“…Silk fibroin derived films are highly flexible, biodegradable and biocompatible in-vitro and in-vivo [15,16]. These properties make silk an outstanding material and an excellent substrate for the fabrication of implantable and degradable bio-optical devices [17].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, silk's ability to be functionalized with biochemistries on one hand and with optical components on the other hand suggests that silk forms an excellent underlying substance for fabricating biomedical materials and biomolecular sensing devices [18][19][20]. Silk films are particularly good for implants and biocompatible substrates (for electronic devices) as they have the ability to establish conformal contact with the curved surfaces of the tissues and organs [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of biocompatible nanodiamond-silk hybrid material

Khalid¹,

Lodin²,

Domachuk³

et al. 2014

Biomed. Opt. Express

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Abstract:A new hybrid material consisting of nanodiamonds (NDs) and silk has been synthesized and investigated. NDs can contain bright fluorescence centers, important for bioprobes to image biological structures at the nanoscale and silk provides a transparent, robust matrix for these nanoparticles in-vivo or in-vitro. The ND-silk hybrid films were determined to be highly transparent in the visible to near infrared wavelength range. The NDs embedded in silk exhibited significant enhancement of emission relative to air, correlating with theoretical predictions. Furthermore, animal toxicity tests confirmed ND-silk films to be non-toxic in an in-vivo mice model. ©201 Optical Society of America

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“…Third, the bottom-up approach also enables high-performance NWFET fabrication on transparent and flexible substrates (24) that facilitates highresolution optical imaging at both surfaces of tissue samples, such as acute brain slices, and intracellular patch clamp measurements. The freedom to design device structures and arrays on substrates adapted to specific applications also opens up unique possibilities for interfacing with living tissues, for example, flexible silicon electronics (25) as well as bio-resorbable and implantable devices (26). Fourth, the active junction area of typical NWFETs, 0.06 μm 2 , is much more localized and, thus, can provide better spatial resolution of signals compared to MEA and planar FETs that are 60 to 10 4 times larger in active area.…”

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Nanowire transistor arrays for mapping neural circuits in acute brain slices

Qing¹,

Pal²,

Tian³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

186

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Revealing the functional connectivity in natural neuronal networks is central to understanding circuits in the brain. Here, we show that silicon nanowire field-effect transistor (Si NWFET) arrays fabricated on transparent substrates can be reliably interfaced to acute brain slices. NWFET arrays were readily designed to record across a wide range of length scales, while the transparent device chips enabled imaging of individual cell bodies and identification of areas of healthy neurons at both upper and lower tissue surfaces. Simultaneous NWFET and patch clamp studies enabled unambiguous identification of action potential signals, with additional features detected at earlier times by the nanodevices. NWFET recording at different positions in the absence and presence of synaptic and ion-channel blockers enabled assignment of these features to presynaptic firing and postsynaptic depolarization from regions either close to somata or abundant in dendritic projections. In all cases, the NWFET signal amplitudes were from 0.3-3 mV. In contrast to conventional multielectrode array measurements, the small active surface of the NWFET devices, ∼0.06 μm 2 , provides highly localized multiplexed measurements of neuronal activities with demonstrated sub-millisecond temporal resolution and, significantly, better than 30 μm spatial resolution. In addition, multiplexed mapping with 2D NWFET arrays revealed spatially heterogeneous functional connectivity in the olfactory cortex with a resolution surpassing substantially previous electrical recording techniques. Our demonstration of simultaneous high temporal and spatial resolution recording, as well as mapping of functional connectivity, suggest that NWFETs can become a powerful platform for studying neural circuits in the brain.

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Silicon electronics on silk as a path to bioresorbable, implantable devices

Cited by 269 publications

References 13 publications

Graphene-based wireless bacteria detection on tooth enamel

Graphene-based wireless bacteria detection on tooth enamel

Synthesis and characterization of biocompatible nanodiamond-silk hybrid material

Nanowire transistor arrays for mapping neural circuits in acute brain slices

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