Silicon Nanoparticles and Microparticles

Mu, Chaofeng; Shen, Haifa

doi:10.1007/978-1-4939-3121-7_8

Cited by 5 publications

(4 citation statements)

References 79 publications

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“…The advent of nanoscale particles with revolutionary physico‐chemical properties, specific applicability, and predictable outcome thus accounts for the rise of nanomedicine. In the biomedical arena, the most prized nanomaterial competitors include liposomes, gold, magnetic, polymer, carbon, silicon, and mesoporous silica/organosilica nanomaterials (see Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Croissant

Fatieiev

Almalik

et al. 2017

Adv Healthcare Materials

474

349

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Predetermining the physico-chemical properties, biosafety, and stimuli-responsiveness of nanomaterials in biological environments is essential for safe and effective biomedical applications. At the forefront of biomedical research, mesoporous silica nanoparticles and mesoporous organosilica nanoparticles are increasingly investigated to predict their biological outcome by materials design. In this review, it is first chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica (periodic mesoporous organosilicas) governs not only the physico-chemical properties but also the biosafety of the nanoparticles. The impact of the hybridization on the biocompatibility, protein corona, biodistribution, biodegradability, and clearance of the silica-based particles is described. Then, the influence of the surface engineering, the framework hybridization, as well as the morphology of the particles, on the ability to load and controllably deliver drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic, ultrasound) are presented. To conclude, trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.

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Section: Introductionmentioning

confidence: 99%

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Croissant

Fatieiev

Almalik

et al. 2017

Adv Healthcare Materials

474

349

View full text Add to dashboard Cite

show abstract

“…The smaller particles had longer blood-circulation lifetimes and larger particles had increased excretion through urine, suggesting a change in degradation rate due to a difference in the smaller and larger MSNs. Although size seems to be an obvious cause for the difference in degradation rate, some consensus is on particle porosity, which could increase with particle size [ 61 ]. Additionally, particles smaller than 10 nm risk renal clearance [ 62 ] while particles greater than 200 nm risk activating the complement system immune response [ 63 ].…”

Section: Interaction Of Mesoporous Silica In the Bodymentioning

confidence: 99%

“…High porosity benefits drug delivery as a higher surface area allows for greater amounts of drug encapsulation. However, increased pore size can also pose the risks of increased reactivity and oxidative stress [ 61 , 105 ]. Nanoparticles with larger surface areas have more exposed silanol groups that can generate reactive oxygen species and damage the structure of biomolecules.…”

Section: Interaction Of Mesoporous Silica In the Bodymentioning

confidence: 99%

Recent Advances of Mesoporous Silica as a Platform for Cancer Immunotherapy

Dai

Wang

et al. 2022

Biosensors

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Immunotherapy is a promising modality of treatment for cancer. Immunotherapy is comprised of systemic and local treatments that induce an immune response, allowing the body to fight back against cancer. Systemic treatments such as cancer vaccines harness antigen presenting cells (APCs) to activate T cells with tumor-associated antigens. Small molecule inhibitors can be employed to inhibit immune checkpoints, disrupting tumor immunosuppression and immune evasion. Despite the current efficacy of immunotherapy, improvements to delivery can be made. Nanomaterials such as mesoporous silica can facilitate the advancement of immunotherapy. Mesoporous silica has high porosity, decent biocompatibility, and simple surface functionalization. Mesoporous silica can be utilized as a versatile carrier of various immunotherapeutic agents. This review gives an introduction on mesoporous silica as a nanomaterial, briefly covering synthesis and biocompatibility, and then an overview of the recent progress made in the application of mesoporous silica to cancer immunotherapy.

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“…The nanotoxicity tests are however being usually performed on model cell lines (in vitro tests). It should be noted that nanotoxicity tests based on cellular lines and organelles do not provide sufficient information about the toxicological effect on the entire organism [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Fresh-Water Mollusks as Biomonitors for Ecotoxicity of Nanomaterials

et al. 2021

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The use of different nanoparticles (NPs) is growing every year since discoveries of their unique properties. The wide use of nanomaterials has raised concerns about their safety and possible accumulation in the aquatic environment. Mussels are being considered as one of the most suitable organisms for bioaccumulation monitoring. Within our study, we focused on developing the method that can be applied in field studies of ecotoxicity and can be nondestructive and informative at early times of exposure, while at the same time being based on changes of physiological parameters of fresh water mussels. The changes in the cardiovascular and neural systems of mollusks (Anodonta anatina and Unio tumidus) were measured as biomarkers of toxic effects. Different monometallic and bimetallic NPs, silicon NPs with various ligands were applied as test substances. Changes in cardiovascular and neural functions were in good correlation with accumulation tests for all tested NPs.

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Silicon Nanoparticles and Microparticles

Cited by 5 publications

References 79 publications

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Recent Advances of Mesoporous Silica as a Platform for Cancer Immunotherapy

Fresh-Water Mollusks as Biomonitors for Ecotoxicity of Nanomaterials

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