Silicon retinal tack for the epiretinal fixation of the polyimide electrode array

Seo, Jong-Mo; Paik, Seung Joon; Kim, Eui‐Tae; Byun, Sung Su; Lee, Ah Ra; Cho, Dong‐il Dan; Kim, Sung June; Yu, Hyeong Gon; Yu, Young Suk; Chung, Hum

doi:10.1016/j.cap.2005.04.013

Cited by 11 publications

(3 citation statements)

References 4 publications

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“…However, substrate integrated flexible MEAs offer an alternative to traditional methods for recording or stimulating the electrical activity from neural cells. The common polymers such as polyimide [10] and PMDS [11], which have become one of the hottest substrate materials for implantable systems in the world, have been applied to manufacture MEAs for their flexibilities. These polymers, however, have some shortcomings themselves such as dielectric loss, vapor permeation and mechanical intensity which are confined to their applications to some extent [12].…”

Section: Introductionmentioning

confidence: 99%

Development of Flexible Neural Microelectode Arrays Based on Parylene for Retinal Prosthesis

Xing

et al. 2008

2008 IEEE International Conference on Networking, Sensing and Control

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Microelectrode arrays (MEAs) have become key components in retinal implants for recording of neural signals or electrical stimulation of nerves. In this paper, implantable flexible MEAs based on a novel polymer, parylene, were developed by designing MEMS process. And electrical performance of prepared microelectrodes was characterized electrochemically. Results showed that impedance and phase delay of testing MEAs were 2000 QA100 Q and -20°from 103Hz to 105 Hz, respectively, which would supply a better application with neural interface for retinal prosthesis.

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Section: Introductionmentioning

confidence: 99%

Development of Flexible Neural Microelectode Arrays Based on Parylene for Retinal Prosthesis

Xing

et al. 2008

2008 IEEE International Conference on Networking, Sensing and Control

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“…In our companion article, we described a method for assessing the localized histopathology of the eye surrounding an implant positioned in the suprachoroidal space 16 The epiretinal location is the most commonly utilised position for locating a visual prosthesis. Electrode arrays situated here are typically affixed to the retina with a metal tack that penetrates all the layers of the eye [17][18][19][20] . Prior to the techniques described in the present manuscript, it was difficult to accurately assess the retinal and other tissues immediately surrounding a tack.…”

Section: Introductionmentioning

confidence: 99%

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

Nayagam

Durmo²,

McGowan

et al. 2015

JoVE

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Retinal prostheses for the treatment of certain forms of blindness are gaining traction in clinical trials around the world with commercial devices currently entering the market. In order to evaluate the safety of these devices, in preclinical studies, reliable techniques are needed. However, the hard metal components utilised in some retinal implants are not compatible with traditional histological processes, particularly in consideration for the delicate nature of the surrounding tissue. Here we describe techniques for assessing the health of the eye directly adjacent to a retinal implant secured epiretinally with a metal tack.Retinal prostheses feature electrode arrays in contact with eye tissue. The most commonly used location for implantation is the epiretinal location (posterior chamber of the eye), where the implant is secured to the retina with a metal tack that penetrates all the layers of the eye. Previous methods have not been able to assess the proximal ocular tissue with the tack in situ, due to the inability of traditional histological techniques to cut metal objects. Consequently, it has been difficult to assess localized damage, if present, caused by tack insertion.Therefore, we developed a technique for visualizing the tissue around a retinal tack and implant. We have modified an established technique, used for processing and visualizing hard bony tissue around a cochlear implant, for the soft delicate tissues of the eye. We orientated and embedded the fixed eye tissue, including the implant and retinal tack, in epoxy resin, to stabilise and protect the structure of the sample. Embedded samples were then ground, polished, stained, and imaged under various magnifications at incremental depths through the sample. This technique allowed the reliable assessment of eye tissue integrity and cytoarchitecture adjacent to the metal tack.

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“…The epiretinal location is the most commonly utilised position for locating a visual prosthesis. Electrode arrays situated here are typically affixed to the retina with a metal tack that penetrates all the layers of the eye [17][18][19][20] . Prior to the techniques described in the present manuscript, it was difficult to accurately assess the retinal and other tissues immediately surrounding a tack.…”

Section: Introductionmentioning

confidence: 99%

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Silicon retinal tack for the epiretinal fixation of the polyimide electrode array

Cited by 11 publications

References 4 publications

Development of Flexible Neural Microelectode Arrays Based on Parylene for Retinal Prosthesis

Development of Flexible Neural Microelectode Arrays Based on Parylene for Retinal Prosthesis

Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks

JoVE Video Dataset

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