Silicone Oils: Physicochemical Properties

Safety and feasibility of a novel intravitreal tamponade using a silicone oil/acetyl-salicylic acid suspension for proliferative vitreoretinopathy: first results of the Austrian Clinical Multicenter Study

“…The use of SiO for surgical stabilization and also for delivering an antiproliferative drug such as aspirin (acetylsalicylic acid, AS) is promising [12]. Our previous studies of the in vitro and in vivo release of AS from an AS/ silicone oil suspension (AS SiO) indicated that significant amounts of AS and salicylic acid (SA) can be released from SiO over a period of 2 to 3 weeks [13].…”

Liquid Injectable Silicone for the Upper Third of the Face

“…Most LIS prior to 1990 was obtained from clandestine sources. Studies have proven that most of those products contained impurities that adversely affected biocompatibility (Parel 1989 ). Injection of such products prior to 1990 was extremely common, with publicity surrounding associated adverse events leading to a negative public image (Duffy 2005 ).…”

Evaluation of silicon oil on bacterial growth

“…According to previous studies, exogenous endophthalmitis incidence is higher in cases of ocular trauma (2.4 -8%), trabeculectomy (0.2 -9.6%) and cataract surgery (0.04 -0.7%). In the event of an ocular trauma with intraocular foreign body, the incidence increases up to 30%, according to some authors (3,4,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) . The most frequently responsible microorganisms of acute exogenous endophthalmitis are Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Streptococcus pneumoniae.…”

“…But it was only after the 1970's, with modern microsurgery, that this technique was widely spread around the world, Jean Haute (France), Relja Zivojnovic (Holand) and Peter Lever (England) combined successfully intraocular injection of the silicon oil and pars plana vitrectomy. Currently, the main indications of its use are complicated cases, when long term tampon effects are required, and infectious en dophthalmitis (1)(2)(3)(4)(5)(6) . One of the most important indications and reason of this study is the infectious endophthalmitis, the most feared complication of the ophthalmological surgeons.…”

“…Silicon oil is a term designated to denominate a group of clear, inert and hydrophobic polymers, chemically derived from siloxane (1)(2)(3)(4) . The first reference of its use in ophthalmology dates back to 1958 with Stone, as a substitute of the vitreous humor in experimental intraocular surgery.…”