Safety and feasibility of a novel intravitreal tamponade using a silicone oil/acetyl-salicylic acid suspension for proliferative vitreoretinopathy: first results of the Austrian Clinical Multicenter Study

Kralinger, Martina; Stolba, U.; Velikay, M.; Egger, S.; Binder, Susanne; Wedrich, Andreas; Haas, Anton; Parel, Jean Marie; Kieselbach, G.

doi:10.1007/s00417-010-1389-7

Cited by 16 publications

(17 citation statements)

References 33 publications

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“…50 A novel randomized control trial studied the use of standard SO tamponade compared to SO containing aspirin, given aspirin's anti-inflammatory properties. 51 Although no adverse effects were observed with administration of SO containing aspirin, no significant differences were observed either in visual acuity or detachment rates at 6-month follow-up. It would be interesting to repeat this study with aspirin dosing adjustments to investigate if a varying concentration would prove beneficial.…”

Section: Surgerymentioning

confidence: 83%

Proliferative Vitreoretinopathy (PVR) Update: Current Surgical Techniques and Emerging Medical Management

Kuriakose

Chin

et al. 2017

Journal of VitreoRetinal Diseases

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To provide an update on current surgical techniques and emerging medical management in proliferative vitreoretinopathy (PVR). Methods: A literature search was conducted on studies in the past decade with the inclusion of historical, landmark studies. Results: Proliferative vitreoretinopathy remains the primary obstacle to successful retinal detachment (RD) surgery, despite increasing knowledge on its pathophysiology and efforts to reduce its occurrence. A number of recent visualization and surgical advancements, including smaller gauge vitrectomies, have shown promising results. Likely, effective PVR prevention and treatment may rest on a multimodal approach, with particular attention toward adjunct pharmacological use. There is a growing body of literature on effective anti-inflammatory, antineoplastic/proliferative, antigrowth factor, and antioxidant adjunct therapy. Nonetheless, a number of preoperative and perioperative risk factors must be assessed before considering any surgical or medical management. Newer preoperative risk factor findings, such as smoking, highlight the need for a broad consideration during patient counseling. Discussion: Most studies in this field are retrospective in design, and the number of randomized control trials is limited, owing to the uncommon nature and complicated clinical profiles of patients with PVR RDs. Prospective studies should consider including combination drug formulations as a part of its intervention. Surgical techniques that may mitigate the inflammatory response by reducing ocular trauma should also continue to be investigated.

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Section: Surgerymentioning

confidence: 83%

Proliferative Vitreoretinopathy (PVR) Update: Current Surgical Techniques and Emerging Medical Management

Kuriakose

Chin

et al. 2017

Journal of VitreoRetinal Diseases

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“…Some authors simply do not use any, preferring generic terms, such as minimal, moderate, and severe PVR [ 21 , 22 ]. Furthermore, early stages of PVR (named as grades A and B), which are common to all classifications, are not used, and most authors refer only to most advanced stages, basically grade C [ 20 , 23 ]. Moreover, the presence of classification errors could indicate that there is confusion concerning their use [ 13 , 16 – 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…An important relevant finding is that only a limited number of clinicians appropriately and fully use the current updated classification of 1991 [ 24 – 27 ], while the majority of authors avoid using the added characteristics of localization, extension, and type, limiting the description to the grade. In addition, many colleagues still use the first reported classification [ 4 ], probably because although it presents many limitations, it is easier to use compared to the last version [ 23 , 28 ]. Additionally, some authors decided to use alternative classification, probably to avoid problems evaluating PVR stages [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Classifications for Proliferative Vitreoretinopathy (PVR): An Analysis of Their Use in Publications over the Last 15 Years

Lauro

Kadhim

Charteris

et al. 2016

Journal of Ophthalmology

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Purpose. To evaluate the current and suitable use of current proliferative vitreoretinopathy (PVR) classifications in clinical publications related to treatment. Methods. A PubMed search was undertaken using the term “proliferative vitreoretinopathy therapy”. Outcome parameters were the reported PVR classification and PVR grades. The way the classifications were used in comparison to the original description was analyzed. Classification errors were also included. It was also noted whether classifications were used for comparison before and after pharmacological or surgical treatment. Results. 138 papers were included. 35 of them (25.4%) presented no classification reference or did not use any one. 103 publications (74.6%) used a standardized classification. The updated Retina Society Classification, the first Retina Society Classification, and the Silicone Study Classification were cited in 56.3%, 33.9%, and 3.8% papers, respectively. Furthermore, 3 authors (2.9%) used modified-customized classifications and 4 (3.8%) classification errors were identified. When the updated Retina Society Classification was used, only 10.4% of authors used a full C grade description. Finally, only 2 authors reported PVR grade before and after treatment. Conclusions. Our findings suggest that current classifications are of limited value in clinical practice due to the inconsistent and limited use and that it may be of benefit to produce a revised classification.

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“…A series of studies using acetylsalicylic acid reported relatively high drug loading in 5000 mPa.s SO (1.67 mg/ml), although filtration to remove undissolved drug was not performed (Kralinger et al 2001a; Kralinger et al 2001b). In a subsequent clinical trial, the acetylsalicylic acid–SO solution was filtered to remove undissolved drug crystals and resulting in significantly lower drug loading of 0.2 mg/ml (Kralinger et al 2010). In vitro , a burst release was observed, with concentration reduced after 3 days and the drug metabolite, salicylate, was undetectable after 30 days.…”

Section: Recent Development and Innovation Of Somentioning

confidence: 99%

Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long‐term tamponade agents

Chen

Kearns

Zhou

et al. 2020

Acta Ophthalmologica

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Silicone oil (SO) has been used as a long-term tamponade agent in the treatment of complicated vitreoretinal diseases for about half a century, during which time many advances in surgical techniques and technologies have been made. This review summarizes the chemical and physical properties of SO, its indications and complications, including particularly emulsification. The mechanisms and risk factors for emulsification are discussed, as well as novel strategies for its effective removal. Finally, the review focuses on new improved formulations of SO, including research into slow-release pharmacological agents within SO and provides an overview of alternatives to SO for the purpose of long-term tamponade that are being developed.

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Safety and feasibility of a novel intravitreal tamponade using a silicone oil/acetyl-salicylic acid suspension for proliferative vitreoretinopathy: first results of the Austrian Clinical Multicenter Study

Abstract: Aspirin delivery by intravitreal silicone oil in the human eye is safe and also may provide a delivery vehicle for other antiproliferative agents to the posterior pole.

Cited by 16 publications

References 33 publications

Proliferative Vitreoretinopathy (PVR) Update: Current Surgical Techniques and Emerging Medical Management

Proliferative Vitreoretinopathy (PVR) Update: Current Surgical Techniques and Emerging Medical Management

Classifications for Proliferative Vitreoretinopathy (PVR): An Analysis of Their Use in Publications over the Last 15 Years

Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long‐term tamponade agents

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