Silicosis – brief review and experience of a pulmonology ward

Santos, Cid Aimbiré de Moraes; Norte, Ana; Fradinho, Fátima; Catarino, André P.; Ferreira, António Jorge; Loureiro, Mário; Baganha, M. Fontes

doi:10.1016/s2173-5115(10)70021-x

Cited by 14 publications

(13 citation statements)

References 15 publications

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“…or mixed?) in silicosis [34]. In the present study, we measured the lung function of individuals to investigate the possible relationship between lung function loss and silicosis.…”

Section: Discussionmentioning

confidence: 98%

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Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis

Liu

Tian

et al. 2020

Mediators of Inflammation

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Silicosis is a devastating disease caused by inhalation of silica dust that leads to inflammatory cascade and then scarring of the lung tissue. Increasing evidences indicate that soluble receptor for advanced glycation end products (sRAGE) is involved in inflammatory diseases. However, no data on the possible relationship between sRAGE and inflammation of silicosis are available. In this study, serum from subjects with silicosis (n=59) or from healthy controls (HC, n=14) was analyzed for the secretion of sRAGE, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), transforming growth factor-β1 (TGF-β1), and oxidized low-density lipoprotein (ox-LDL). The associations between sRAGE and cytokines and ox-LDL and lung function were assessed by Pearson’s correlation analyses. Mean levels of serum sRAGE were lower in silicosis than those in controls (p<0.05). The subjects who had a longer term of occupational exposure had higher levels of sRAGE (p<0.05). The secretion of TNF-α, IL-1β, IL-6, TGF-β1, and ox-LDL was significantly higher in the silicosis group than that in the HC group (p<0.05). Furthermore, the levels of sRAGE were negatively correlated with TNF-α, IL-6, IL-1β, and ox-LDL. There is no correlation between sRAGE and TGF-β1 and lung function. The optimal point of sRAGE for differentiating silicosis from healthy controls was 14250.02 pg/ml by ROC curve analysis. A decrease in serum sRAGE and its association with inflammatory response might suggest a role for sRAGE in the pathogenesis of silicosis.

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“…or mixed?) in silicosis [34]. In the present study, we measured the lung function of individuals to investigate the possible relationship between lung function loss and silicosis.…”

Section: Discussionmentioning

confidence: 98%

“…Silicosis is a complicated disease, which can present as acute silicosis, accelerated silicosis, and chronic silicosis [34]. As far as we know, the diagnosis of silicosis is based on a history of silica exposure and the radiography abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis

Liu

Tian

et al. 2020

Mediators of Inflammation

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“…A apresentação clínica e a evolução da silicose estão muito dependentes da interação entre o hospedeiro e o ambiente ocupacional. Assim, a silicose pode apresentar-se sob diversas formas: silicose crónica (simples ou complicada), silicose acelerada e silicoproteinose (Santos et al 2010;Greenberg, Waksman, & Curtis, 2007, Leung, Yu, & Chen, 2012.…”

Section: Silicoseunclassified

Doenças Ocupacionais Respiratórias – Perspetivas Atuais

Ferreira

2018

RILP

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As doenças ocupacionais são uma das causas mais significativas de morte e incapacidade relacionada com o trabalho. Dentro das múltiplas patologias desta família que podem afetar o ser humano, tomam principal destaque as afeções ocupacionais de etiologia respiratória, quer pelo seu significado a nível nacional e internacional, quer sobretudo pela sua gravidade e anos potenciais de vida perdidos. Constituem uma causa significativa de sintomatologia respiratória no trabalhador, bem como de absentismo, incapacidade e morte. Dentro da grande variedade de doenças ocupacionais respiratórias, o autor dá particular destaque às Pneumoconioses (provocadas pela inalação de poeiras minerais, quer sejam fibras ou partículas e sua subsequente resposta pulmonar, com particular impacto para a inalação de sílica cristalina respirável e amianto); Pneumonite de Hipersensibilidade Profissional (doença pulmonar complexa causada por uma reação imunitária desencadeada após a exposição respiratória a uma ampla variedade de antigénios; Asma Ocupacional (caracterizada por limitação variável do fluxo aéreo e/ou hiper-reatividade das vias aéreas, devidas a causas e condições atribuíveis a um ambiente de trabalho em particular e não a estímulos encontrados fora do local de trabalho) e Neoplasias Respiratórias Ocupacionais, com particular destaque para o cancro do pulmão e o mesotelioma pleural maligno).

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“…Currently there is no specific treatment for silicosis. Although stopping silica exposure can improve the prognosis, it does not prevent disease progression, which ultimately leads to death …”

Section: Introductionmentioning

confidence: 99%

“…Although stopping silica exposure can improve the prognosis, it does not prevent disease progression, which ultimately leads to death. [5][6][7][8][9] According to data from the International Society for Heart and Lung Transplantation, 10 silicosis rarely indicates lung transplantation (LTx). However, end-stage silicosis can cause irreversible and severe lung damage, and in this case, LTx can be lifesaving and may represent the only option for these patients.…”

Section: Introductionmentioning

confidence: 99%

What is expected in lung function after lung transplantation due to end‐stage pulmonary silicosis?

Sidney-Filho

Watte

Santos

et al. 2017

Clinical Transplantation

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In this study, we aimed to determine the impact of lung transplantation (LTx) on pulmonary function tests (PFTs) and survival among patients with end-stage silicosis. We included patients with end-stage silicosis on the wait list for LTx, between January 1989 and July 2015 (N = 26). Sixteen of these patients received LTx; 10 were eligible, but did not undergo LTx (non-LTx) during the study period. Retrospective information on PFTs (spirometry [volumes and flows], 6-minute walking test [6MWT], and DLCO) was retrieved from patients' medical charts, including baseline information for all patients and follow-up information for the LTx. At baseline, most patients presented with spirometric and 6MWT values that were suggestive of severe disease (FEV /FVC 76.5 ± 29.7; 6MWT 267.4 ± 104.5 m). Significant increases in these values were observed at follow-up in the LTx (P = .036 and .151, respectively). The overall median survival of patients in the LTx and non-LTx was 3.35 years (95% CI: 0.16-14.38) and 0.78 years (95% confidence interval [CI]: 0.12-3.65) (P = 0.002), respectively. For patients with end-stage silicosis, LTx offers significant benefits regarding pulmonary function and survival when compared to non-LTx, and is a reliable tool to help this critical population of patients, whose only treatment option is LTx.

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Silicosis – brief review and experience of a pulmonology ward

Cited by 14 publications

References 15 publications

Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis

Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis

Doenças Ocupacionais Respiratórias – Perspetivas Atuais

What is expected in lung function after lung transplantation due to end‐stage pulmonary silicosis?

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