Silicosis in sandblasters of shipyard versus silicosis in stone carvers in Brazil: A comparison of imaging findings, lung function variables and cardiopulmonary exercise testing parameters

Lopes, Agnaldo José; Costa, W.S.; Mafort, Thiago Thomáz; Ferreira, Arthur de Sá; Menezes, Sara Lucia Silveira de; Guimarães, Fernando Silva

doi:10.1016/j.rppnen.2012.06.002

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…Remarkably, evidence has been shown indicating that silicotic rats treated with cortisone also showed reduction of the amount of silica particles in the lungs and a little increase of silica detected in the lymph nodes (45). It is known from patients that inhaled silica particles not only affect the lungs but also other organs, mainly mediastinal lymph nodes, although the underlying mechanism is still poorly understood (46)(47)(48). Thus, it is conceivable that IL-13-PE might exert its inhibitory effect upon pulmonary silicosis, at least in part, by increasing the lymphaticmediated drainage of silica crystals from the lungs.…”

Section: Discussionmentioning

confidence: 99%

IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice

Ferreira

Arantes

Nascimento

et al. 2013

The Journal of Immunology

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Instillation of silica into the lungs of rodents results in pathological changes that strongly mimic human silicosis, an occupational lung disease marked by restrictive airway obstruction, inflammation, and fibrosis. Because IL-13 is a pivotal proinflammatory and fibrogenic cytokine, we examined whether a recombinant immunotoxin comprised of human IL-13 and a mutated form of Pseudomonas exotoxin (IL-13–PE) might affect pathological features of experimental silicosis. Mice received a single intranasal instillation of silica particles and were treated with intranasal IL-13–PE every other day from days 21 to 27 postsilica. The sensitivity of putative cell targets to IL-13–PE was also assessed in in vitro settings. Upregulation of IL-13, its receptor subunits IL-13Rα1 and IL-13Rα2, and shared receptor IL-4Rα were associated with development of granulomatous lung inflammation triggered by silica. IL-13–PE inhibited silica-induced granuloma and fibrotic responses noted at 24 h and 15 d after the last treatment. Upregulation of TNF-α, TGF-β, and chemokines, as well as increased collagen deposition and airway hyperreactivity to methacholine were all clearly sensitive to IL-13–PE. In addition, IL-13–PE inhibited both IL-13–induced proliferation of cultured lung fibroblasts from silicotic mice and silica-induced IL-8 generation from A549 cells. In conclusion, our findings show that therapeutic treatment with IL-13–PE can reverse important pathological features caused by inhalation of silica particles, suggesting that this recombinant immunotoxin is a promising molecular template in drug discovery for the treatment of silicosis.

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Section: Discussionmentioning

confidence: 99%

IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice

Ferreira

Arantes

Nascimento

et al. 2013

The Journal of Immunology

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“…The TLV (i.e. the sum of air plus tissue volume) was calculated as follows: [(size of the pixel) 2 3 slice thickness 3 total number of pixels of the region of interest for the whole lung]. The X-ray attenuation of each pixel, expressed in Hounsfield units (HU), was calculated by the density (mass/volume ratio) of the tissue and shown as the CT number, that is, CT/(-1000) 5 [volume of gas/(volume of gas 1 volume of tissue)].…”

Section: Pulmonary Densitometrymentioning

confidence: 99%

“…12,14,31 This CT number is achieved, in any given pixel, by determining the percentage of radiation absorbed by that volume of the lung. Then, the weight of the lungs was calculated as follows: [(1 2 CT/21000) 3 (size of the pixel) 2 3 slice thickness 3 total number of pixels of the region of interest for the whole lung]. 12,14,32,33 The weight of the lungs was the sum of the weight of all selected pixels.…”

Section: Pulmonary Densitometrymentioning

confidence: 99%

“…The most common occupations at risk for silicosis are those involving tunnels, quarry and mine drilling, and foundry activities. 2 Simple silicosis is characterized by the presence of multiple nodules measuring 1-10 mm in diameter that are distributed predominantly in the superior and posterior segments of the upper lobes. Complicated silicosis, also called progressive massive fibrosis (PMF), is characterized by the presence of large opacities with homogeneous consolidation areas that mainly affect the superior and middle segments of the lungs.…”

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confidence: 99%

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Relationships between the pulmonary densitometry values obtained by CT and the forced oscillation technique parameters in patients with silicosis

Lopes

Mogami²,

Camilo³

et al. 2015

BJR

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Objective: To evaluate the correlations between pulmonary densitometry values and forced oscillation technique (FOT) parameters in patients with silicosis. Methods: This cross-sectional study comprised 36 nonsmoker patients with silicosis and 20 matched control subjects who were submitted to FOT and multidetector CT (MDCT). Results: Compared with the control subjects, the MDCT evaluation demonstrated that patients with silicosis exhibited greater total lung mass. These patients also had larger non-aerated and poorly aerated compartments, which included nodules and scarring. Compared with the control subjects, FOT evaluation demonstrated that patients with silicosis exhibited changes in both reactive and resistive properties of the respiratory system. In these patients, there was a greater heterogeneity of the respiratory system and increased work of breathing. Significant correlations between non-aerated compartment size and FOT parameters that reflect the non-homogeneity of the respiratory system were observed. The dynamic compliance of the respiratory system was negatively correlated with non-aerated compartment size, while the impedance at 4 Hz was positively correlated with non-aerated compartment size. Conclusion: Patients with silicosis have heavier lungs. In these patients, a larger non-aerated compartment is associated with a worsening of lung function. A more significant pulmonary involvement is associated with a loss of homogeneity and increased mechanical load of the respiratory system. Advances in knowledge: The findings provided by both pulmonary densitometry and FOT may add valuable information to the subjective analysis of silicosis; however, more studies are necessary to evaluate the potential use of these methods for assessing disease progression.

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Cardiopulmonary Exercise Stress Testing – an Update

Demeter¹

2014

AMA Guides® Newsletter

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This article updates one published in The Guides Newsletter in January/February 1998 and reflects changing legislation in the workers’ compensation area and also in motor accident compensation. In the various Australian state and federal jurisdictions, impairment rating has become an important component of independent medical examinations, and in many areas, impairment guides have been adopted as a mandatory tool for assessing permanent impairment. For example, in the mid-1990s the state of Victoria established use of the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fourth Edition, as the sole tool for evaluating impairment and continues to use this edition to the present time. Despite the publication of the AMA Guides, Fifth Edition, in 2000, the Motor Accidents Authority in New South Wales (NSW) continues to use the fourth edition, supplemented with the NSW Motor Accidents Authority Guidelines. In November 2001, Tasmania adopted the same guidelines that were being used by the NSW Motor Accidents Authority. Despite publication of the AMA Guides, Sixth Edition, in 2007, there has remained a general reticence in Australia to progress to use of this latest edition either as stand-alone impairment rating tools or an underpinning of the purpose-developed impairment guidelines already in place. A large number of Australian medical assessors have become used to the model based on the NSW WorkCover Guides for the Evaluation of Permanent Impairment, which interprets the AMA Guides, Fifth Edition.

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Silicosis in sandblasters of shipyard versus silicosis in stone carvers in Brazil: A comparison of imaging findings, lung function variables and cardiopulmonary exercise testing parameters

Cited by 7 publications

References 28 publications

IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice

IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice

Relationships between the pulmonary densitometry values obtained by CT and the forced oscillation technique parameters in patients with silicosis

Cardiopulmonary Exercise Stress Testing – an Update

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