Silicotuberculosis and silicosis as occupational diseases: Report of two cases

Milovanović, Aleksandar; Nowak, Dennis; Milovanović, Aleksa; Hering, K. G.; Kline, Joel N.; Kovalevskiy, Evgeny; Kundiev, Ilich Yuriy; Perunicić, B; Popević, Martin B.; Šuštran, Branka; Nenadović, M.

doi:10.2298/sarh1108536m

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…Our studies revealed that both pathological characteristic and bacteriological indexes in different stages of silicosis rats with tuberculosis were similar to that of corresponding clinical patients, 15 which confirmed the reasonableness of it for study. In the future, such a model will be used to explore the specific pathogenesis of silicosis tuberculosis and provide more theoretical support for the treatment.…”

Section: Discussionsupporting

confidence: 77%

Establishment of rat model of silicotuberculosis and its pathological characteristic

Dong

Yabo

et al. 2014

Pathogens and Global Health

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Objective: To establish different stages of silicosis rat model complicated with tuberculosis infection, and compare the pathological characteristics and analyze the impact of silicosis on tuberculosis infection. Methods: SD rats were subjected to intratracheal administration of silica with non-exposure method at the 1st, 30th, or 60th day. At the 50th day, the rats were injected with the suspension of H37Rv (a virulent standard strain of Mycobacterium tuberculosis) via tail-vein. After 40 days post-infection, rats were sacrificed, the lung tissues were isolated, and paraffin was embedded and sectioned. The sections were treated using HE staining for structure observation, acid fast stain of Ziehl-Neelsen for bacterial detection, and Warthin-Starry silver staining for displaying the distribution of dust particles. The bacterial load was quantified by colony counting. Results: Primary to tertiary silicosis could be discovered at the 30th, 60th, and 90th day of post-infection. The rats could be infected by injection of M. tuberculosis via tail vein, with tuberculosis load and the degree of lung tissue lesions positively correlated with silicosis. Conclusion: The rat model of silicotuberculosis was established successfully, which facilitated understanding the 'cross-talk' of silicosis and tuberculosis during the process they drive each other.

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Section: Discussionsupporting

confidence: 77%

Establishment of rat model of silicotuberculosis and its pathological characteristic

Dong

Yabo

et al. 2014

Pathogens and Global Health

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“…In patients with silicosis, it is extremely important to exclude the coexistence of active tuberculosis. However, the diagnosis of active tuberculosis superimposed on silicosis can be very difficult, because the clinical manifestations can be benign and the radiological alterations can be indistinguishable from those resulting from the preexisting silicosis [ 17 ]. Therefore, in cases of clinical suspicion of concomitant active tuberculosis, an appropriate additional investiga¬tion should be performed.…”

Section: Discussionmentioning

confidence: 99%

Silico-tuberculosis and associated risk factors in central province of Iran

Farazi¹,

Jabbariasl²

2015

Pan Afr Med J

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IntroductionCo-existence of silicosis and tuberculosis is known as silico-tuberculosis. This article review the frequency of silicosis and tuberculosis in workers who exposed to silica and evaluate influencing factors that may increase the risk of silico-tuberculosis.MethodsAn analytical cross-sectional study was performed in silica exposed workers in central province of Iran during 2011-2012. Sampling method was un-randomized and considering all workers who at least 6 months exposed to silica. The study was done via questionnaire, clinical examination, spirometry, chest x-ray and tuberculosis investigations.ResultsA total of 3121 workers were included in the study, the mean age of participants was 43.1±12.4 years, and mean employment duration 14.9±6.8 years. Prevalence of TB in silica-exposed workers without silicosis was 172 cases per 100 000 people and prevalence in silicosis cases was 917 cases per 100 000 people. Incidence of TB in silica-exposed workers without silicosis was 69 cases per 100 000 people and incidence in silicosis cases was 459 cases per 100 000 people. The frequency of LTBI/TB was higher in age over thirty years old (P = 0.02), in workers with employment duration over 10 years (P = 0.004), in workers with exposure duration over 5 years (P = 0.03) and smokers with over 5 pack-years (P = 0.01).ConclusionExposure to silica causes a renewed multiplication of bacilli in the healing TB lesions. Prevalence of pulmonary tuberculosis in Silicosis is more common when compared to prevalence in general population, hence all should use prophylactic measures Intensification of work place.

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“…Both the patients presented diffuse lung fibrosis, small nodular opacities, and homogenous calcifications noted predominantly in the upper and middle lobes. 15 The other case study published by Mulliez et al, 16 reported 65-year-old male patient with silicotuberculosis developed broncholithiasis. A case of silicotuberculosis in a 76-yearold woman who has exposure of 3 years to silica dust was complicated by broncholithiasis and oesophagobronchial fistula and relapsed TB even on 9 months of anti-TB treatment.…”

Section: Discussionmentioning

confidence: 93%

Prevalence of concomitant pulmonary tuberculosis in patients with newly diagnosed silicosis in a tertiary care center in South India

2023

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Background: Long-term exposure to silica dust makes people prone for silicosis which raises the risk of the individual in developing pulmonary tuberculosis (PTB). Silicosis is a progressive lung disease characterize with shortness of breath, cough, fever, and bluish skin, caused due to inhalation of crystalline silica dust found in abundance in sand, rock, and quartz. Aims and Objectives: The disease is known to effect the functioning of macrophages making it unable to defend mycobacterium species, thus allowing the bacterium to invade and develop tuberculosis. Materials and Methods: A retrospective cross-sectional study is carried out to estimate the prevalence of PTB in newly diagnosed silicosis patients at Madurai Medical College, Madurai, Tamil Nadu. All the patients who got registered in Occupational Lung Diseases Registry from January 2016 to December 2021 are included in the study. Silicosis patients tested positive on sputum CBNAAT are considered as silicotubercular patients, whose prevalence is calculated. Results: Our study included a total of 54 subjects (90.8% males and 8.2% female) with mean SD age of 38±6.7 years ranging from 26 to 53 years. Of which 22 patients, 40.7% tested positive for Mycobacterium tuberculosis (MTB) on sputum CBNAAT. The prevalence of MTB in among silicosis patients was found to be 40.7%. Conclusions: Association of TB and silicosis is very strong with the prevalence of TB among silicosis patients as 40.7%. Our study also observed the male sex and elder age as elevated risk of developing silicotuberculosis. All the people getting exposed to silica dust need to be educated in the usage and usefulness of protective equipment.

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Silicotuberculosis and silicosis as occupational diseases: Report of two cases

Abstract: In low-income countries, new cases of silicosis and associated lung cancer, chronic obstructive pulmonary disease and tuberculosis are likely to be seen for decades because necessary reduction of silica use will take time to be achieved.

Cited by 8 publications

References 7 publications

Establishment of rat model of silicotuberculosis and its pathological characteristic

Establishment of rat model of silicotuberculosis and its pathological characteristic

Silico-tuberculosis and associated risk factors in central province of Iran

Prevalence of concomitant pulmonary tuberculosis in patients with newly diagnosed silicosis in a tertiary care center in South India

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