Silk-based anisotropical 3D biotextiles for bone regeneration

Ribeiro, Viviana P.; Silva‐Correia, Joana; Nascimento, Ana Isabel; Morais, Alain da Silva; Marques, A. P.; Ribeiro, Ana Sofia; Silva, Carla Joana; Bonifácio, Graça; Sousa, Rui A.; Oliveira, Joaquim M.; Oliveira, Ana; Reis, Rui L.

doi:10.1016/j.biomaterials.2017.01.027

Cited by 52 publications

(49 citation statements)

References 60 publications

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“…In natural cartilage tissue, the ECM provides a complex environment of physical, chemical and mechanical cues that directly affect and guide cell behavior. In the recent years, SF has demonstrated to be a robust natural material widely explored for bone [41], cartilage [27] and osteochondral [42] TE. Its processing versatility allowed to extend the use of SF for TE applications of ligament [43], blood vessels [44] or skin [45].…”

Section: Discussionmentioning

confidence: 99%

Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration

et al. 2018

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In cartilage tissue engineering (TE), several processing technologies have been combined to create scaffolds for efficient tissue repair. In our study, we propose novel silk fibroin (SF) scaffolds derived from enzymatically crosslinked SF hydrogels processed by salt-leaching and freeze-drying technologies, for articular cartilage applications. Though these scaffolds, we were able to combine the elastic properties of hydrogel-based systems, with the stability, resilience and controlled porosity of scaffolds processed via salt-leaching and freeze-drying technologies. SF protein has been extensively explored for TE applications, as a result of its mechanical strength, elasticity, biocompatibility, and biodegradability. Thus, the structural, mechanical and biological performance of the proposed scaffolds potentiates their use as three-dimensional matrices for cartilage regeneration.

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Section: Discussionmentioning

confidence: 99%

Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration

et al. 2018

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“…Silk‐based scaffolds presented good biological performance when seeded with hASCs. In a work performed by Ribeiro et al, SF biotextiles also showed good hASCs adhesion and proliferation, as well as the ability of these type of cells to differentiate in an osteogenic lineage.…”

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confidence: 99%

Fast Setting Silk Fibroin Bioink for Bioprinting of Patient‐Specific Memory‐Shape Implants

Costa

Silva‐Correia

Oliveira

et al. 2017

Adv Healthcare Materials

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The pursuit for the "perfect" biomimetic and personalized implant for musculoskeletal tissue regeneration remains a big challenge. 3D printing technology that makes use of a novel and promising biomaterials can be part of the solution. In this study, a fast setting enzymatic-crosslinked silk fibroin (SF) bioink for 3D bioprinting is developed. Their properties are fine-tuned and different structures with good resolution, reproducibility, and reliability can be fabricated. Many potential applications exist for the SF bioinks including 3D bioprinted scaffolds and patient-specific implants exhibiting unique characteristics such as good mechanical properties, memory-shape feature, suitable degradation, and tunable pore architecture and morphology.

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“…Silk is a natural fibrous polymer consisting of repetitive protein sequences and due to its characteristics such as elasticity, biocompatibility and biodegradability have applicability for bone regeneration [113][114][115]. Three different scaffolds: alginate, alginate/hydroxyapatite, and alginate/hydroxyapatite/silk fibroin were analyzed in an experiment [115].…”

Section: Polymer Biomaterialsmentioning

confidence: 99%

Scaffolds and coatings for bone regeneration

Pereira

Cengiz

Silva

et al. 2020

J Mater Sci: Mater Med

109

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Bone tissue has an astonishing self-healing capacity yet only for non-critical size defects (<6 mm) and clinical intervention is needed for critical-size defects and beyond that along with non-union bone fractures and bone defects larger than critical size represent a major healthcare problem. Autografts are, still, being used as preferred to treat large bone defects. Mostly, due to the presence of living differentiated and progenitor cells, its osteogenic, osteoinductive and osteoconductive properties that allow osteogenesis, vascularization, and provide structural support. Bone tissue engineering strategies have been proposed to overcome the limited supply of grafts. Complete and successful bone regeneration can be influenced by several factors namely: the age of the patient, health, gender and is expected that the ideal scaffold for bone regeneration combines factors such as bioactivity and osteoinductivity. The commercially available products have as their main function the replacement of bone. Moreover, scaffolds still present limitations including poor osteointegration and limited vascularization. The introduction of pores in scaffolds are being used to promote the osteointegration as it allows cell and vessel infiltration. Moreover, combinations with growth factors or coatings have been explored as they can improve the osteoconductive and osteoinductive properties of the scaffold. This review focuses on the bone defects treatments and on the research of scaffolds for bone regeneration. Moreover, it summarizes the latest progress in the development of coatings used in bone tissue engineering. Despite the interesting advances which include the development of hybrid scaffolds, there are still important challenges that need to be addressed in order to fasten translation of scaffolds into the clinical scenario. Finally, we must reflect on the main challenges for bone tissue regeneration. There is a need to achieve a proper mechanical properties to bear the load of movements; have a scaffolds with a structure that fit the bone anatomy. Graphical Abstract* Helena Filipa Pereira

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Silk-based anisotropical 3D biotextiles for bone regeneration

Cited by 52 publications

References 60 publications

Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration

Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration

Fast Setting Silk Fibroin Bioink for Bioprinting of Patient‐Specific Memory‐Shape Implants

Scaffolds and coatings for bone regeneration

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