Silk-coated dexamethasone non-spherical microcrystals for local drug delivery to inner ear

Li, Min; Ai, Mingyue; Yang, Yuzhou; Yao, Xianhua; Zhou, Zhimin; Wang, Haiyan; Li, Chen; Xu, Kaixu

doi:10.1016/j.ejps.2020.105336

Cited by 11 publications

(4 citation statements)

References 36 publications

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“…For the negative control group, PBS buffer was used instead of the primary antibody. To visualize GR binding and study if GR expression was upregulated by the conjugates and NPs, a dose of 1.67 mg/kg was used according to the literature. , The nucleus and cytoplasm were blue, and the receptors appeared brownish yellow (Figure A). According to the immunohistochemistry for the control group, GRs were located in the organ of Corti (OC), spiral ganglion cells (SGCs), and the spiral ligament and stria vascularis (SL&SV) of the cochlea, which were consistent with the results of ref .…”

Section: Resultsmentioning

confidence: 99%

Design, Synthesis, and Biological Evaluation of Dexamethasone–Salvianolic Acid B Conjugates and Nanodrug Delivery against Cisplatin-Induced Hearing Loss

Sun

Peng

et al. 2021

J. Med. Chem.

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Cisplatin (CDDP) is an extensively used chemotherapeutic agent but has a high incidence of severe ototoxicity. Although a few molecules have entered clinical trials, none have been approved to prevent or treat CDDP-induced hearing loss by the Food and Drug Administration. In this study, an amphiphilic drug–drug conjugate was synthesized by covalently linking dexamethasone (DEX) and salvianolic acid B (SAL) through an ester or amide bond. The conjugates could self-assemble into nanoparticles (NPs) with ultrahigh drug loading capacity and favorable stability. Compared with DEX, SAL, or their physical mixture at the same concentrations, both conjugates and NPs showed enhanced otoprotection in vitro and in vivo. More importantly, the conjugates and NPs almost completely restored hearing in a guinea pig model with good biocompatibility. Immunohistochemical analyses suggested that conjugates and NPs activated the glucocorticoid receptor, which may work as one of the major mechanisms for their protective effects.

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Section: Resultsmentioning

confidence: 99%

Design, Synthesis, and Biological Evaluation of Dexamethasone–Salvianolic Acid B Conjugates and Nanodrug Delivery against Cisplatin-Induced Hearing Loss

Sun

Peng

et al. 2021

J. Med. Chem.

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“…After degumming, SF can be prepared into different forms of materials, such as film [ 19 ], gel [ 20 ], microcapsule [ 21 ], 3D printed scaffold [ 22 ], fiber [ 23 , 24 ] and micro/nano particle [ 25 ] among others. These materials can be applied for drug delivery [ 21 , 26 ], wound healing [ 20 , 27 ], tissue engineering [ 28 , 29 ] and environment-related applications as well as in the energy sector [ 30 ]. However, the intrinsic properties of silk proteins depend on their source and processing methods applied [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Research Progress of Ionic Liquid Dissolving Silks for Biomedicine and Tissue Engineering Applications

Heng

Deng

Yang

et al. 2022

IJMS

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Ionic liquids (ILs) show a bright application prospect in the field of biomedicine and energy materials due to their unique recyclable, modifiability, structure of cation and anion adjustability, as well as excellent physical and chemical properties. Dissolving silk fibroin (SF), from different species silkworm cocoons, with ILs is considered an effective new way to obtain biomaterials with highly enhanced/tailored properties, which can significantly overcome the shortcomings of traditional preparation methods, such as the cumbersome, time-consuming and the organic toxicity caused by manufacture. In this paper, the basic structure and properties of SF and the preparation methods of traditional regenerated SF solution are first introduced. Then, the dissolving mechanism and main influencing factors of ILs for SF are expounded, and the fabrication methods, material structure and properties of SF blending with natural biological protein, inorganic matter, synthetic polymer, carbon nanotube and graphene oxide in the ILs solution system are introduced. Additionally, our work summarizes the biomedicine and tissue engineering applications of silk-based materials dissolved through various ILs. Finally, according to the deficiency of ILs for dissolving SF at a high melting point and expensive cost, their further study and future development trend are prospected.

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“…In contrast, water-insoluble polymers such as cellulose acetate (CA), can provide sustained release (Aidana et al, 2021). Such work has increasingly been performed at the nanoscale to generate new advanced DDSs (Démuth, et al, 2015;Grossen, et al, 2017;Li, et al, 2020). However, the influence of the outer shape of nanostructure is carelessly overlooked，in part because few techniques can be employed to manipulate the outer shape at the nanoscale, and fewer can systematically tailor the composition, internal structure, and outer shape.…”

Section: Introductionmentioning

confidence: 99%

Combination of structure-performance and shape-performance relationships for better biphasic release in electrospun Janus fibers

Zheng

Kang

Wang

et al. 2021

International Journal of Pharmaceutics

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Silk-coated dexamethasone non-spherical microcrystals for local drug delivery to inner ear

Cited by 11 publications

References 36 publications

Design, Synthesis, and Biological Evaluation of Dexamethasone–Salvianolic Acid B Conjugates and Nanodrug Delivery against Cisplatin-Induced Hearing Loss

Design, Synthesis, and Biological Evaluation of Dexamethasone–Salvianolic Acid B Conjugates and Nanodrug Delivery against Cisplatin-Induced Hearing Loss

Recent Research Progress of Ionic Liquid Dissolving Silks for Biomedicine and Tissue Engineering Applications

Combination of structure-performance and shape-performance relationships for better biphasic release in electrospun Janus fibers

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