Silk Fibroin Crosslinked Glycyrrhizic Acid and Silver Hydrogels for Accelerated Bacteria‐Infected Wound Healing

Zhang, Fan; Yin, Chuanjin; Qi, Xueju; Guo, Chenglin; Wu, Xiaochen

doi:10.1002/mabi.202100407

Cited by 15 publications

(16 citation statements)

References 30 publications

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“…Silk fibroin (SF) is a natural protein-based biopolymer [ 54 , 60 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ]. Silk fibers are primarily composed of proteins derived from silkworms, namely fibroin, sericin, and 18 different amino acids [ 56 , 113 ].…”

Section: Polymersmentioning

confidence: 99%

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Ribeiro,

Simões,

Vitorino

et al. 2024

Gels

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Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol. This review offers a comprehensive overview and critical analysis of the key polymers that can constitute hydrogels, beginning with a brief contextualization of the polymers. It delves into their function, origin, and chemical structure, highlighting key sources of extraction and obtaining. Additionally, this review encompasses the main intrinsic properties of these polymers and their roles in the wound healing process, accompanied, whenever available, by explanations of the underlying mechanisms of action. It also addresses limitations and describes some studies on the effectiveness of isolated polymers in promoting skin regeneration and wound healing. Subsequently, we briefly discuss some application strategies of hydrogels derived from their intrinsic potential to promote the wound healing process. This can be achieved due to their role in the stimulation of angiogenesis, for example, or through the incorporation of substances like growth factors or drugs, such as antimicrobials, imparting new properties to the hydrogels. In addition to substance incorporation, the potential of hydrogels is also related to their ability to serve as a three-dimensional matrix for cell culture, whether it involves loading cells into the hydrogel or recruiting cells to the wound site, where they proliferate on the scaffold to form new tissue. The latter strategy presupposes the incorporation of biosensors into the hydrogel for real-time monitoring of wound conditions, such as temperature and pH. Future prospects are then ultimately addressed. As far as we are aware, this manuscript represents the first comprehensive approach that brings together and critically analyzes fundamental aspects of both natural and synthetic polymers constituting hydrogels in the context of cutaneous wound healing. It will serve as a foundational point for future studies, aiming to contribute to the development of an effective and environmentally friendly dressing for wounds.

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Section: Polymersmentioning

confidence: 99%

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Ribeiro,

Simões,

Vitorino

et al. 2024

Gels

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“…101 Furthermore, silver nanoparticles with antibacterial properties and glycyrrhizic acid (GA) with anti-inflammatory properties were also introduced into the silk fibroin hydrogel matrix to generate a dressing for wound healing. 102 structure of which contributes to the strength and hierarchical structure of bone tissue. 103 Benefiting from their high toughness, robust mechanical strength, excellent biocompatibility, and slow biodegradability, silk fibroin hydrogel-derived bone tissue engineering scaffolds have been developed as a very popular choice.…”

Section: Skin Regenerationmentioning

confidence: 99%

Silk fibroin hydrogels for biomedical applications

Zhang

et al. 2022

Smart Medicine

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Silk fibroin hydrogels occupy an essential position in the biomedical field due to their remarkable biological properties, excellent mechanical properties, flexible processing properties, as well as abundant sources and low cost. Herein, we introduce the unique structures and physicochemical characteristics of silk fibroin, including mechanical properties, biocompatibility, and biodegradability. Then, various preparation strategies of silk fibroin hydrogels are summarized, which can be divided into physical cross‐linking and chemical cross‐linking. Emphatically, the applications of silk fibroin hydrogel biomaterials in various biomedical fields, including tissue engineering, drug delivery, and wearable sensors, are systematically summarized. At last, the challenges and future prospects of silk fibroin hydrogels in biomedical applications are discussed.

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“…The structural amphiphilicity and chirality make GA molecules display anisotropic self-assembly behavior in aqueous solutions, forming long and semiflexible nanofibrils with a right-handed twist, 2.5 nm thickness, and 9 nm periodicity, which further form supramolecular hydrogels with a hydrogen-bond 3D network at a concentration over 0.3 wt %. , Our previous studies have shown that the controllable assembly of these GA nanofibrils at liquid interfaces and in the aqueous phase makes them highly suitable as building blocks for preparing multiphase colloidal materials with high stability, stimulability, and processability. − Furthermore, the multiple functional groups, rigid skeletons, and unique stacking behaviors of GA molecules render them as an ideal platform for creating various GA derivatives, which can be further used as building blocks to develop versatile soft material. , Inspired by the unique combination of the interesting self-assembly and the inherent biological activities, we speculate that GA can be used as natural bifunctional building blocks for fabricating bioactive hydrogels with the capability to combat bacterial infections, suppress inflammatory responses, and thereby restore wound tissue function back to normal physiological activity. Recent studies also demonstrate that GA-based bioactive hydrogels show the potential for wound dressings. − However, owing to the lack of adequate mechanical strength, adhesion, and self-healing ability, the GA hydrogel dressings would be easily damaged by normal human body movement or local stress, which results in low therapeutic efficiency and limits their practical biomedical applications. Therefore, endowing the GA hydrogels with sufficient mechanical strength and multifunctionality is critical for the development of new bioactive GA hydrogel dressings with ideal potential clinical transformation effects.…”

Section: Introductionmentioning

confidence: 99%

Injectable Self-Healing Adhesive Natural Glycyrrhizic Acid Bioactive Hydrogel for Bacteria-Infected Wound Healing

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Bioactive hydrogels self-assembled from naturally occurring herbal small molecules are attracting growing interest for applications in wound healing, due to their versatile intrinsic biological activities, excellent biocompatibility, as well as facile, sustainable, and eco-friendly processes. However, the development of supramolecular herb hydrogels with sufficient strength and multifunctionality as an ideal wound dressing in clinical practice remains a challenge. In this work, inspired by the efficient clinic therapy and directed self-assembly of natural saponin glycyrrhizic acid (GA), we create a novel GA-based hybrid hydrogel to promote full-thickness wound healing and bacterial-infected wound healing. This hydrogel possesses excellent stability and mechanical performance and multifunctional properties, including injectable, shape-adaptation and remodeling, self-healing, and adhesive abilities. This is attributed to the hierarchical dual-network that comprises the self-assembled hydrogen-bond fibrillar network of aldehyde-contained GA (AGA) and the dynamic covalent network through Schiff base reaction between AGA and a biopolymer carboxymethyl chitosan (CMC). Notably, benefiting from the inherent strong biological activity of GA, the AGA-CMC hybrid hydrogel exhibits unique and significant anti-inflammation effects and antibacterial ability, especially toward the Gram-positive Staphylococcus aureus (S. aureus). In vivo experiments demonstrate that the AGA-CMC hydrogel promotes uninfected skin wound healing and S. aureus-infected skin wound healing by enhancing the formation of granulation tissue, facilitating collagen deposition, reducing bacterial infection, and downregulating inflammatory response. This study highlights the design of new and multifunctional bioactive herb hydrogels from natural drug-food homologous small molecules, which can serve as a promising wound-healing dressing for biomedical applications.

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Silk Fibroin Crosslinked Glycyrrhizic Acid and Silver Hydrogels for Accelerated Bacteria‐Infected Wound Healing

Cited by 15 publications

References 30 publications

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Silk fibroin hydrogels for biomedical applications

Injectable Self-Healing Adhesive Natural Glycyrrhizic Acid Bioactive Hydrogel for Bacteria-Infected Wound Healing

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