Silk fibroin nanoparticle as a novel drug delivery system

Mottaghitalab, Fatemeh; Farokhi, Mehdi; Shokrgozar, Mohammad Ali; Hosseinkhani, Hossein

doi:10.1016/j.jconrel.2015.03.020

Cited by 342 publications

(211 citation statements)

References 230 publications

(208 reference statements)

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“…The improvement of cellular uptake, the reduction of the side effects, the control of drug release, the enhancement of drug bioavailability, and the reduction of the drug degradation rate are the purposes of drug delivery systems [2]. Recently, nanoparticles are considered to be suitable for drug delivery due to their ability to act as modifiable platforms, their tunable size, and their high surface-to-volume ratio [2]. In addition, they can be used to deliver hydrophilic and hydrophobic drug molecules as well [3].…”

Section: Introductionmentioning

confidence: 99%

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Silk Fibroin Nanoparticles for Drug Delivery: Effect of Bovine Serum Albumin and Magnetic Nanoparticles Addition on Drug Encapsulation and Release

et al. 2018

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Silk fibroin nanoparticles were prepared in the present study based on phase separation between silk fibroin and polyvinyl alcohol. The drug encapsulation efficiency of the prepared nanoparticles was examined at a range of concentrations from 10 ppm to 500 ppm for pramipexole, curcumin, and propranolol hydrochloride. Silk fibroin nanoparticles encapsulated with propranolol presented the highest drug release profile. In order to improve the drug encapsulation efficiency and drug release performance, a modification of silk fibroin nanoparticles with bovine serum albumin and magnetic nanoparticles was tried. The modification was found to improve the drug encapsulation and release of the modified nanoparticles. Bovine-serum-modified nanoparticles presented the best improvement.

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Section: Introductionmentioning

confidence: 99%

“…Silk fibroin, from the silk worm Bombyx mori, consists of hydrophobic and hydrophilic regions [2]. The hydrophobic domains, i.e., protein crystals and beta sheets, are dominated by repeats of alanine, glycine-alanine, and glycine-alanine-serine.…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin Nanoparticles for Drug Delivery: Effect of Bovine Serum Albumin and Magnetic Nanoparticles Addition on Drug Encapsulation and Release

et al. 2018

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“…7 Nevertheless, in consideration of bio-safety and bioconsistency, natural materials show much greater advantages and development potential than synthetic materials especially in the food and pharmaceutical elds.…”

Section: -4mentioning

confidence: 99%

Synthesis and characterization of calcium-induced peanut protein isolate nanoparticles

et al. 2017

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A convenient and green synthetic route using calcium ion induction was first used to prepare peanut protein isolate (PPI) nanoparticles. Through dynamic light scattering (DLS) and transmission electron microscopy (TEM), the role of each procedure in the formation of nanoparticles was systematically investigated by means of particle size, size distribution, and morphology observation. The size of the obtained nanoparticles ranged from 80 to 140 nm, and they exhibited a uniform size distribution and spherical shape. After dry processing, PPI nanoparticles still display a good state in terms of size and morphology.Stability test results indicated that PPI nanoparticles have good thermal stability, gastrointestinal pH stability, dilution stability and storage stability. In particular, these nanoparticles still have good stability with their concentration diluted to 0.05 mg mL À1 while they can be stored for up to 60 days with particle sizes still below 120 nm at room temperature. All these features endow PPI nanoparticles with great potential in the delivery of bioactive compounds.

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“…However, the potential biohazards of engineered inorganic nanoparticles, including their impact on health and environment, have extensively limited their clinical applications. Therefore, researchers have shifted their focus from inorganic to organic nanomaterials, such as poly(lactic-co-glycolic acid), 10,11 chitosan, 12 polypeptides, 13 liposomes, 14 silk fibroin, 15 lipids, [16][17][18] and carbon-based nanomaterials. 19,20 Recently, carbon nanomaterials including carbon nanotubes, 21 carbon nanohorns (CNHs), 22 carbon nanodiamonds, 23 and graphene (GN) 24 have been studied for applications in drug delivery, owing to their excellent biocompatibility, superhydrophilicity, cell internalization property, enhanced permeability and retention (EPR) effect, and flexibility toward surface modifications.…”

Section: Introductionmentioning

confidence: 99%

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

Zhang¹,

Yao²,

Wei³

et al. 2017

IJN

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Low toxicity and high efficacy are the key factors influencing the real-world clinical applications of nanomaterial-assisted drug delivery. In this study, novel hollow carbon spheres (HCSs) with narrow size distribution were developed. In addition to demonstrating their ease of synthesis for large-scale production, we also demonstrated in vitro that the HCSs possessed high drug-loading capacity, lower cell toxicity, and optimal drug release profile at low pH, similar to the pH in the tumor microenvironment. The HCSs also displayed excellent immunocompatibility and could rapidly distribute themselves in the cytoplasm to escape lysosomal clearance. More importantly, the HCSs could efficiently deliver doxorubicin (a representative chemotherapeutic drug) to tumor sites, which resulted in significant inhibition of tumor growth in an esophageal xenograft cancer model. This also prolonged the circulation time and altered the biodistribution of the drug. In conclusion, this study revealed a novel drug delivery system for targeted tumor therapy.

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Silk fibroin nanoparticle as a novel drug delivery system

Cited by 342 publications

References 230 publications

Silk Fibroin Nanoparticles for Drug Delivery: Effect of Bovine Serum Albumin and Magnetic Nanoparticles Addition on Drug Encapsulation and Release

Silk Fibroin Nanoparticles for Drug Delivery: Effect of Bovine Serum Albumin and Magnetic Nanoparticles Addition on Drug Encapsulation and Release

Synthesis and characterization of calcium-induced peanut protein isolate nanoparticles

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

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