Silk, metal and bone: why take implants out?

Aspenberg, Per

doi:10.1038/nrrheum.2014.57

Cited by 7 publications

(8 citation statements)

References 9 publications

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“…and for treatment of osteoporotic fractures in the elderly [2,3]. In particular, the need for a secondary surgery [4] and the associated increased risk of infection and various other complications associated with such surgeries have been noted [5,6]. Moreover, the mechanical properties of the current bioinert metal alloy systems are not always ideal for bone fixation, and in some cases can release potentially toxic and irritating metal particulates [7,8].…”

Section: Introductionmentioning

confidence: 99%

Control of magnesium alloy corrosion by bioactive calcium phosphate coating: Implications for resorbable orthopaedic implants

et al. 2019

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Control of the corrosion that occurs in magnesium alloys in vivo is a significant challenge for their use as resorbable orthopaedic implants. In this work, we report on the provision of bioactive calcium phosphate (CaP) coatings on magnesium alloys that can delay substrate corrosion while offering an attendant physiochemical environment with properties known to promote an osteoinductive response in vivo. RF magnetron sputtering from hydroxyapatite (HA) powder targets has been employed to create CaP coatings on AZ31 magnesium alloy substrates. Coatings of 70 and 210 nm thickness were achieved via regulation of sputtering parameters, in particular deposition time. XPS and ToF-SIMS were used to investigate the chemistry of the coating alloy interface and also to confirm composition and thickness. The Ca/P atomic ratio of the coatings was determined by EDX to be 1.54. μCT analysis showed a substrate volume loss after 14 days exposure to SBF of 5.89 ± 3.15 mm 3 for the un-coated alloy while the presence of the ~70 nm CaP coating reduced this to 3.42 ± 0.48 mm 3 and the ~210 nm coating to 0.30 ± 0.28 mm 3. The corrosion rates were calculated to be 1.74 ± 0.06 mmpy for the AZ31 control; 1.57 ± 0.09 mmpy for the ~70 nm CaP coated alloy and 1.01 ± 0.07 mmpy for the ~210 nm thick CaP coating. These data confirm that CaP coating

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Section: Introductionmentioning

confidence: 99%

Control of magnesium alloy corrosion by bioactive calcium phosphate coating: Implications for resorbable orthopaedic implants

et al. 2019

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“…An argument against use of polymers for structural support is that although, metal implants are non-degradable, they have been shown to remain in the body for decades without any complications. Technology has further enhanced adhesion of metal implants with host tissue, and hence it is considered safe to leave the implants in the body and there is no need to perform a second surgery to remove them from the body [96]. …”

Section: Polymeric Implants For Screws and Platesmentioning

confidence: 99%

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

Agarwal

Garcı́a

2015

Advanced Drug Delivery Reviews

635

399

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Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone defects and complex fractures still present a significant challenge to the medical community. Current treatments center on metal implants for structural and mechanical support and auto- or allo-grafts to substitute long bone defects. Metal implants are associated with several complications such as implant loosening and infections. Bone grafts suffer from donor site morbidity, reduced bioactivity, and risk of pathogen transmission. Surgical implants can be modified to provide vital biological cues, growth factors and cells in order to improve osseointegration and repair of bone defects. Here we review strategies and technologies to engineer metal surfaces to promote osseointegration with the host tissue. We also discuss strategies for modifying implants for cell adhesion and bone growth via integrin signaling and growth factor and cytokine delivery for bone defect repair.

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“…[4][5][6] Even so, it would be more useful to control the mechanical strength of the PEEK implant over a wider range to increase its similarity to natural bone. [7,8] However, PEEK demonstrates bioinertness, inferior cell adhesion and growth, and poor integration with the surrounding bone. [9,10] A high percentage of post-orthopedic implant surgery failures are caused by the disintegration of PEEK implant with natural bone at the contact site (interface) with natural bone, which requires additional surgeries.…”

Section: Introductionmentioning

confidence: 99%

Topography‐Supported Nanoarchitectonics of Hybrid Scaffold for Systematically Modulated Bone Regeneration and Remodeling

Jang

Park

Lee

et al. 2022

Adv Funct Materials

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Orthopedic implants should have sufficient strength and promote bone tissue regeneration. However, most conventional implants are optimized for use either under high mechanical load or for active osseointegration. To achieve the dual target of mechanical durability and biocompatibility, polyether ether ketone (PEEK) filaments reinforced with internal titanium dioxide (TiO2) nanoparticles via dopamine‐induced polymerization are additively manufactured into an orthopedic implant through material extrusion (ME). The exterior of the PEEK/TiO2 composite is coated with hydroxyapatite (HA) using radiofrequency (RF) magnetron sputtering to increase both the strength and biocompatibility provided by homogeneous ceramic–ceramic interactions and the protuberant nanoscale topography between the internal TiO2 nanoparticle reinforcement and external HA coating. The hardness, tensile, and compression, and scratch test results demonstrate a considerable enhancement in the mechanical strength of the hierarchical PEEK/TiO2/HA hybrid composite structure compared to that of the conventional 3D‐printed PEEK. Furthermore, PEEK with internal TiO2 reinforcement improves the proliferation and differentiation of bone cells in vitro, whereas the external HA coating leads to a more prevalent osteoblast absorption. Micro‐computed tomography and histological analyses confirm new bone formation and a high bone‐to‐implant contact ratio on the HA‐coated PEEK structure reinforced with TiO2 nanoparticles.

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Silk, metal and bone: why take implants out?

Cited by 7 publications

References 9 publications

Control of magnesium alloy corrosion by bioactive calcium phosphate coating: Implications for resorbable orthopaedic implants

Control of magnesium alloy corrosion by bioactive calcium phosphate coating: Implications for resorbable orthopaedic implants

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

Topography‐Supported Nanoarchitectonics of Hybrid Scaffold for Systematically Modulated Bone Regeneration and Remodeling

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