Silk proteins for biomedical applications: Bioengineering perspectives

Kundu, Banani; Kurland, Nicholas E.; Bano, Subia; Patra, Chinmoy; Engel, Felix B.; Yadavalli, Vamsi K.; Kundu, Subhas C.

doi:10.1016/j.progpolymsci.2013.09.002

Cited by 393 publications

(342 citation statements)

References 204 publications

(242 reference statements)

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“…Despite the remarkable of man-made synthetics biomaterial, their applications have been limited by challenges in biocompatibility, biodegradability and bioresorbability. Keys for improvement is lies in the development of functional materials that can interact with biological systems [1]. Virgin silks, is having an issues of biocompatibility if uses as sutures, with reactions from delayed hypersensitivity to acute and chronic process of inflammatory.…”

Section: Introductionmentioning

confidence: 99%

“…The absence of the silk sericin that is released by degummed silk fiber, demonstrate minimum reaction of inflammatory, which enables successful implantation and cell culture. silk for biomaterial requires the separation of sericin from fibroin [1]. The biomaterial extracted from silk can be produce in the form of particle, fiber, hydrogels, scaffold, and film [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…silk for biomaterial requires the separation of sericin from fibroin [1]. The biomaterial extracted from silk can be produce in the form of particle, fiber, hydrogels, scaffold, and film [1,2]. Some silks already explored for biomaterial such as Bombyxmorifrom domesticated mulberry silkworm or from non-mulberry silk such as Antheraeamylitta, Antheraeaassamenis, Antheraeapernyi, Philosamiaricini, Samiacyn-thiaricini [1].…”

Section: Introductionmentioning

confidence: 99%

“…The biomaterial extracted from silk can be produce in the form of particle, fiber, hydrogels, scaffold, and film [1,2]. Some silks already explored for biomaterial such as Bombyxmorifrom domesticated mulberry silkworm or from non-mulberry silk such as Antheraeamylitta, Antheraeaassamenis, Antheraeapernyi, Philosamiaricini, Samiacyn-thiaricini [1]. Other African source of non-mulberry wild silkworm cocoon also come in to attention like Gonometapostica, Epiphorabauhiniae, Anaphe panda, and Argemamimosae [3].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Indigenous Indonesian Wild Silkworm Cocoon of Attacus atlas as Biocompatible Film Biomaterial

Nindhia¹,

Knejzlı́k²,

Ruml³

et al. 2017

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. The biocompatible film made from wild silkworm cocoon of Attacus atlas is intorduced in this research for anticipation of demand on biocompatible film for regenerative medicine. The wild silkworm cocoon was indigenous Indonesia and was taken from it original location in Indonesia. Protocol for degumming method was obtained in this research by using treatment with NaOH solution at 0.1 M for 1 hour. The film was prepared by grinding the wet degummed fiber until pulp like state was obtained. The mixture was dropped in sequence on the hot ceramic plate with temperature around 60 o C. The film thickness can be controlled precisely by using this technique. The film is soaked in alcohor for 1 day for stability testing and the result is found stable. The film is introduced in to COS-1 Cell suspension with previously washed in PBS solution and put in a chamber for biocompatibility testing. The cell are found able to grow and attach in first day observation and dramatically increase after 3 days observation. This is an indicate that the film that is produced from wild silkworm cocon of Attacus atlas has excellent biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Indigenous Indonesian Wild Silkworm Cocoon of Attacus atlas as Biocompatible Film Biomaterial

Nindhia¹,

Knejzlı́k²,

Ruml³

et al. 2017

IOP Conf. Ser.: Mater. Sci. Eng.

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“…Silk fibroin is a nature protein and is known to promote cell attachment and proliferation and tissue regeneration. It has been reported that the biological features of silk fibroin make it a very good choice for use as regeneration [2,3]. Silk fibroin has been widely explored in many biomedical applications due to its impressive biocompatibility, biodegradability, minimal inflammatory reactions [4,5].…”

Section: Introductionmentioning

confidence: 99%

Property of electrospinning silk fibroin nanofibers prepared by different dissolved methods

Zhou

Yao

et al. 2016

MATEC Web Conf.

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Abstract. In the present study, silk was dissolved in CaCl 2 -formic acid and CaCl 2 -C 2 H 5 OH-H 2 O to obtain silk fibroin solution. The dissolve process, morphology, structure and mechanical properties of nanofibers prepared by electrospinning were studied. It showed that nanofibril structures were exhibited in the silk fibroin solution in CaCl 2 -formic acid compared with traditional method dissolving in CaCl 2 -C 2 H 5 OH-H 2 O solution, and the viscosity of the solution was much higher. The average diameter of nanofibers prepared by CaCl 2 -formic acid dissolution method was 375±26nm, and it showed well drawability, after stretching to 1 times, its breaking strength and elongation at break reaching 18.6±3.8MPa and 14.0±2.5%, respectively, was improved obviously relative to nanofibers prepared by CaCl 2 -C 2 H 5 OH-H 2 O dissolution method. It demonstrated that the good mechanical property of fibers was contributed to the fibrillar structures in the solution.

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Silk

Asakura

Kametani

Suzuki

2018

Encyclopedia of Polymer Science and Technology

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Silks are naturally spun fibrous proteins most often associated with silkworms and spiders. For more than 5000 years, silk fiber from Bombyx mori silkworm has been used by mankind as an excellent textile fiber “queen of textiles.” Silk fibers possess excellent mechanical properties due to a combination of strength and extensibility, biocompatibility, and biodegradability. Thus, silks are of high interest for researchers in many fields. Here, we review the current understandings of the production, structures, processing, and properties of silkworms and spider silks. In vivo and in vitro findings in the field of silk research are the basis for the design of new proteins and processing strategies, which will enable applications of these fascinating protein‐based materials in the fields of biomedicine and materials engineering.

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Silk proteins for biomedical applications: Bioengineering perspectives

Cited by 393 publications

References 204 publications

Indigenous Indonesian Wild Silkworm Cocoon of Attacus atlas as Biocompatible Film Biomaterial

Indigenous Indonesian Wild Silkworm Cocoon of Attacus atlas as Biocompatible Film Biomaterial

Property of electrospinning silk fibroin nanofibers prepared by different dissolved methods

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