Silk suture granuloma with false-positive findings on PET/CT accompanied by peritoneal metastasis after colon cancer surgery

Matsuura, Sohei; Sasaki, Kazuhito; Kawasaki, Hiroshi; Abe, Hideki; Nagai, Hideo; Yoshimi, Fuyo

doi:10.1016/j.ijscr.2016.09.002

Cited by 16 publications

(18 citation statements)

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“…Suture granulomas have shown increased uptake of 18 F-fluorodexyglucose, probably because of the presence of granulation tissue associated with chronic inflammation, during positron emission tomography (PET)/CT examinations in previous studies, thus leading to false-positive results [ [10] , [11] , [12] , [13] ]. In many previous reports, patients have received unnecessary extended resection or harmful chemotherapy for suspected malignancies.…”

Section: Discussionmentioning

confidence: 99%

Suture granulomas developing after the treatment of oral squamous cell carcinoma

Yoshioka

Nakatao

Hamana

et al. 2018

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Suture granulomas developing after the treatment of oral squamous cell carcinoma

Yoshioka

Nakatao

Hamana

et al. 2018

International Journal of Surgery Case Reports

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“…In women who have undergone surgery for ovarian cancer, foreign body granulomas mainly formed around the suture materials or clips. Silk sutures cause more allergic reactions and infections than monofilament sutures, and foreign body granulomas occur more frequently in Asia where silk sutures are used more frequently [ 22 ]. Foreign body granuloma is not well detected on CT or MRI because it is radiopaque.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of integrated ¹⁸F-fluoro-2-deoxyglucose positron emission tomography/computed tomography in recurrent epithelial ovarian cancer: accuracy of patient selection for secondary cytoreduction in 134 patients

et al. 2018

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ObjectiveThe aim of this study was to evaluate the diagnostic value of integrated 18F-fluoro-2-deoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) for suspected recurrence of epithelial ovarian cancer (EOC) with non-disseminated lesions.MethodsWe retrospectively reviewed the medical records of recurrent EOC patients who underwent secondary cytoreduction from January 2000 to December 2013. A total of 134 patients underwent secondary cytoreduction after imaging with either 18F-FDG-PET/CT or contrast-enhanced computed tomography (CECT).ResultsIn a patient-based analysis of 134 patients, 124 (92.5%) were confirmed to be positive for malignancy. Among 72 patients with suspected non-disseminated recurrence on 18F-FDG-PET/CT, 65 (89.0%) were confirmed to have recurrence, giving 98.5% sensitivity, 87.7% accuracy, and 88.9% positive predictive value (PPV). In the 65 patients with recurrence, residual tumor remained in 14 patients, giving an accuracy of patient selection for secondary cytoreduction of 69.4% (50/72) and it is higher than that of CECT (64.0%). In 169 lesions removed from patients who underwent preoperative 18F-FDG-PET/CT, 135 (79.9%) were confirmed to be positive for malignancy and 124 were accurately detected by 18F-FDG-PET/CT, giving 91.9% sensitivity, 81.1% accuracy, and 85.5% PPV. Foreign body granuloma was found in 33.3% of 21 lesions with false-positive 18F-FDG-PET/CT findings (7/21). The mean preoperative cancer antigen 125 (CA-125) level in false-positive patients was 28.8 U/mL.ConclusionCompared with CECT, 18F-FDG-PET/CT shows higher sensitivity in lesion-based analysis and better accuracy of patient selection for secondary cytoreduction. However, there is still a need for integration of the results of 18F-FDG-PET/CT, CECT, and CA-125 levels to aid treatment planning.

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“…15 Its worthwhile to note that suture granulomas can present as enhancing masses on MRI or CT and can be associated with increased uptake at F-18 fluoro deoxy glucose (FDG)-Positron Emission Tomography (PET)/CT imaging. 16,17…”

Section: Discussionmentioning

confidence: 99%

Polypropylene Granuloma After Zone 1-5 Extensor Tendon Repair

Ramakrishnan¹,

Sageer²

2017

jebmh

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BACKGROUND Extensor tendon injuries are common cases seen in any orthopaedic outpatient department. In general, the consequences of repair of extensor tendon injuries are considered favourable with minimal postoperative complications and residual deformities. One of the rare complications seen is a foreign body granuloma occurring at the suture site. This poses a diagnostic challenge to the surgeon as it may be a delayed presentation. MATERIALS AND METHODS Fifteen patients presenting with swelling at suture site and discharging sinus from the suture site after their extensor tendon injuries of hand were sutured with polypropylene formed the study group. RESULTS Removal of suture and debridement with primary closure resulted in resolution of symptoms. CONCLUSION In the event of foreign body granuloma, exploration, debridement and removal of sutures seem to be an adequate procedure, which gives predictable and favourable results. When dealing with tendon repair in areas with minimal subcutaneous tissue, it is advisable not to leave suture ends so that it irritates the skin and may lead to foreign body granulomas.

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Silk suture granuloma with false-positive findings on PET/CT accompanied by peritoneal metastasis after colon cancer surgery

Cited by 16 publications

References 16 publications

Suture granulomas developing after the treatment of oral squamous cell carcinoma

Suture granulomas developing after the treatment of oral squamous cell carcinoma

Diagnostic value of integrated ¹⁸F-fluoro-2-deoxyglucose positron emission tomography/computed tomography in recurrent epithelial ovarian cancer: accuracy of patient selection for secondary cytoreduction in 134 patients

Polypropylene Granuloma After Zone 1-5 Extensor Tendon Repair

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Silk suture granuloma with false-positive findings on PET/CT accompanied by peritoneal metastasis after colon cancer surgery

Cited by 16 publications

References 16 publications

Suture granulomas developing after the treatment of oral squamous cell carcinoma

Suture granulomas developing after the treatment of oral squamous cell carcinoma

Diagnostic value of integrated 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography in recurrent epithelial ovarian cancer: accuracy of patient selection for secondary cytoreduction in 134 patients

Polypropylene Granuloma After Zone 1-5 Extensor Tendon Repair

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Diagnostic value of integrated ¹⁸F-fluoro-2-deoxyglucose positron emission tomography/computed tomography in recurrent epithelial ovarian cancer: accuracy of patient selection for secondary cytoreduction in 134 patients