No abstract

HighlightsA 64-year-old man underwent head and neck surgery for oral squamous cell carcinoma.Multiple suture granulomas mimicking tumor recurrence developed in the radiation field.The suture granulomas developed shortly after adjuvant chemoradiation therapy.Suspect suture granulomas when nodules appear during postoperative radiotherapy.Suture granulomas may show spontaneous resolution.

Currently, immunotherapy using immune checkpoint inhibitors including nivolumab, ipilimumab, and pembrolizumab has been the main treatment for patients with recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). Nivolumab is a human monoclonal antibody targeting programmed death (PD)-1. It is approved for patients with platinum-refractory R/M SCCHN according to the results of the CheckMate 141 trial. 1,2 There have been many reports of immunotherapy with nivolumab for R/M SCCHN in Japan since it was approved by the Japanese Authorized Committee in March 2017. 3,4 However, to the best of our knowledge, no case had been reported of locoregional advanced (LA) tongue cancer successfully controlled for more than 5 years using nivolumab monotherapy after induction chemotherapy (IC) with docetaxel (DTX), cisplatin (CDDP), and 5-fluorouracil (5-FU) followed by bioradiotherapy (BRT) and subsequent cetuximab monotherapy. Herein, we present a case of a patient with LA tongue cancer who achieved complete remission using nivolumab monotherapy after a multidisciplinary therapy. | Case reportA 66-year-old woman was referred to our hospital due to swelling of the left side of her neck in September 2015. She had no history of alcohol drinking or cigarette smoking. However, she had a history of hypertension. Both her father and elder sister died of colorectal and thyroid cancer, respectively. On clinical examination, an ulcerated mass extending to the underside of the left side of the tongue from the lateral tongue margin with a large adhesive cervical mass exceeding 100 mm in diameter was observed (Figure 1A,B).Contrast-enhanced computed tomography (CT) showed that this primary tumor occupied almost half of the left side of the tongue and had invaded the extrinsic muscles of the tongue, extending to

Purpose: To determine the clinical and therapeutic characteristics in adolescent and young adult (AYA) generation with oral cancer. Methods: We retrospectively studied AYA patients with oral cancer, aged 16-40 years who visited our department between 1 April 1997 and 31 December 2017, focusing on clinical characteristics including sex, age distribution, tumor site, pathological classification, stage, treatment, treatment outcome, and social rehabilitation. Results: Forty-two patients of AYA generation (19 males and 23 females), accounting for five. Seven percent of all oral cancer patients (740), were included. Most were aged 35-39 (median, 30.9) years. The most frequent site of tumor occurrence was the tongue (n = 29) and the most common histological type was squamous cell carcinoma (n = 30). Most patients had T2N0 cancer based on the TNM classification, and early stage II. Thirty-nine patients underwent radical treatment, comprising 14 cases of surgery, six of chemo-radiation therapy, four of surgery with chemotherapy, and two of surgery with radiation therapy. Conversely, nine patients underwent radical radiation therapy, comprising five cases of internal radiation therapy and four of This article is based on a study first reported in the Journal of the Japanese