Silkworm-based silk fibers by electrospinning

Zhou, Chan-Juan; Li, Ya; Yao, Shao-Wen; He, Ji‐Huan

doi:10.1016/j.rinp.2019.102646

Cited by 46 publications

(32 citation statements)

References 44 publications

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“…Several procedures have been described to obtain the protein solution require for the creation of the different regenerated silk fibroin formats. For example, Zhous et al (2019) used the solution prepared by mechanically stirring the silkworm cocoon in an alcoholic solution [ 70 ]. However, such methods provide a lower control on the properties of the solution since, for instance, the protein concentration is not easily measured.…”

Section: Fabrication Methods and Platforms For Regenerated Sf-basementioning

confidence: 99%

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

et al. 2021

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Silk refers to a family of natural fibers spun by several species of invertebrates such as spiders and silkworms. In particular, silkworm silk, the silk spun by Bombyx mori larvae, has been primarily used in the textile industry and in clinical settings as a main component of sutures for tissue repairing and wound ligation. The biocompatibility, remarkable mechanical performance, controllable degradation, and the possibility of producing silk-based materials in several formats, have laid the basic principles that have triggered and extended the use of this material in regenerative medicine. The field of neural soft tissue engineering is not an exception, as it has taken advantage of the properties of silk to promote neuronal growth and nerve guidance. In addition, silk has notable intrinsic properties and the by-products derived from its degradation show anti-inflammatory and antioxidant properties. Finally, this material can be employed for the controlled release of factors and drugs, as well as for the encapsulation and implantation of exogenous stem and progenitor cells with therapeutic capacity. In this article, we review the state of the art on manufacturing methodologies and properties of fiber-based and non-fiber-based formats, as well as the application of silk-based biomaterials to neuroprotect and regenerate the damaged nervous system. We review previous studies that strategically have used silk to enhance therapeutics dealing with highly prevalent central and peripheral disorders such as stroke, Alzheimer’s disease, Parkinson’s disease, and peripheral trauma. Finally, we discuss previous research focused on the modification of this biomaterial, through biofunctionalization techniques and/or the creation of novel composite formulations, that aim to transform silk, beyond its natural performance, into more efficient silk-based-polymers towards the clinical arena of neuroprotection and regeneration in nervous system diseases.

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Section: Fabrication Methods and Platforms For Regenerated Sf-basementioning

confidence: 99%

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

et al. 2021

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“…Equation (23) implies that the diffusion rate depends upon only the fiber radius; a smaller fiber predicts a faster diffusion process, so nanoscale hollow fibers by the electrospinning process [36][37][38][39][40][41][42][43][44] are much needed for a fast ion release at the initial stage.…”

Section: Discussionmentioning

confidence: 99%

Fractal diffusion of silver ions in hollow cylinders with unsmooth inner surface

Yao

2019

Journal of Engineered Fibers and Fabrics

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“…Having a fibrous structure, SF should be prone to ES without additives and the feasibility of this process has already been proven in the literature, by performing ES from the formic acid [ 104 , 105 , 106 ] or aqueous solutions [ 107 ]. Still, as the process is challenging, the majority of the studies report performing electrospinning with various co-polymers: collagen [ 108 ], PEO [ 109 , 110 , 111 , 112 ], or PVA [ 113 , 114 ]. Post-electrospinning, the fibers can be stabilized by methanol/ethanol [ 104 , 105 , 106 , 108 , 109 , 110 , 111 ], EDC-NHS [ 107 ], or GTA + HCl [ 113 ].…”

Section: Examples Of the Electrospinnable Biopolymersmentioning

confidence: 99%

“…The indicated stabilization mechanism of the alcohols or EDC-NHS is the transition of the amorphous structure into β-sheet conformation, while GTA + HCl induces chemical cross-linking. Interestingly, Zhou et al [ 114 ] and Serodito et al [ 112 ], in their articles from 2019, indicated that there is no need for additional stabilization steps. While Zhou did not provide proof of a prolonged stability of the fibers, Serodito performed 7-day-long in vitro studies, by directly seeding the human cells from the periodontal ligament (hPDLs) onto the scaffolds.…”

Section: Examples Of the Electrospinnable Biopolymersmentioning

confidence: 99%

Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

Wilk

Benko

2021

JFB

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Biopolymers formed into a fibrous morphology through electrospinning are of increasing interest in the field of biomedicine due to their intrinsic biocompatibility and biodegradability and their ability to be biomimetic to various fibrous structures present in animal tissues. However, their mechanical properties are often unsatisfactory and their processing may be troublesome. Thus, extensive research interest is focused on improving these qualities. This review article presents the selection of the recent advances in techniques aimed to improve the electrospinnability of various biopolymers (polysaccharides, polynucleotides, peptides, and phospholipids). The electrospinning of single materials, and the variety of co-polymers, with and without additives, is covered. Additionally, various crosslinking strategies are presented. Examples of cytocompatibility, biocompatibility, and antimicrobial properties are analyzed. Special attention is given to whey protein isolate as an example of a novel, promising, green material with good potential in the field of biomedicine. This review ends with a brief summary and outlook for the biomedical applicability of electrospinnable biopolymers.

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Silkworm-based silk fibers by electrospinning

Cited by 46 publications

References 44 publications

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

Fractal diffusion of silver ions in hollow cylinders with unsmooth inner surface

Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

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