Silver Containing Biomaterials

Poulter, Neil; Vasilev, Krasimir; Griesser, Stefani S.; Griesser, Hans J.

doi:10.1007/978-1-4614-1031-7_14

Cited by 7 publications

(7 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, since silver is increasingly used to hinder bacterial infections, widespread silver resistance that may cause adverse effects on humans and the ecosystem is of increasing concern. 2,3 Antibacterial coatings in biomedical applications may in vivo be compromised by protein adsorption that influences the kinetics of the silver release and provides a platform for bacterial attachment at the adsorbed protein layer. 3 It is well known that spontaneous and nonspecific adsorption of proteins in solution will take place in contact with a surface due to the heterogeneous molecular surface of proteins that consists of hydrophobic and hydrophilic patches with positive and negative charges, dipoles, and hydrogen-bonding groups.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years the number of applications has increased due to its broad spectrum of antimicrobial properties. − Because of the rapid development of nanotechnology, the use of silver has accelerated in medical and biomedical applications, for air and water purification, in food manufacturing, in cosmetics, in clothing, and in a number of household products (such as refrigerators). It has been shown that the antimicrobial properties to a large extent derive from the release of silver ions from the silver-containing product. − In biomedical applications silver has mainly been used as an active species incorporated in antibacterial coatings on biomaterials and in wound dressings. Antibacterial biomaterial surfaces should not cause any adverse effects on cells, tissues, or fluids (e.g., blood, tears).…”

Section: Introductionmentioning

confidence: 99%

“…Antibacterial biomaterial surfaces should not cause any adverse effects on cells, tissues, or fluids (e.g., blood, tears). However, since silver is increasingly used to hinder bacterial infections, widespread silver resistance that may cause adverse effects on humans and the ecosystem is of increasing concern. , …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adsorption of Lysozyme on Silver and Its Influence on Silver Release

et al. 2014

View full text Add to dashboard Cite

Silver is increasingly used in antimicrobial coatings of biomedical devices and implants to hinder infections. As proteins have been shown to largely influence the extent of released metals from various metal surfaces at biological conditions, silver may also be influenced in the same way. The aim of this study is to relate the structure of adsorbed lysozyme (LSZ) to the release of silver from metallic silver surfaces. Simultaneous adsorption measurements were performed in real time on the same surface using combined ellipsometry and quartz crystal microbalance with dissipation monitoring measurements to provide a more comprehensive understanding on the adsorption kinetics and the layer structures. The concentration of LSZ in 0.15 M NaNO3 solution (pH 7, 25 °C) influences the structure of the adsorbed layer. Monolayer coverage is obtained at concentrations ≤0.1 g/L, while a bilayer structure with a rigid inner layer and a relatively loosely adsorbed outer layer is formed at 1 g/L. The inner layer of LSZ is assumed to bind firmly to silver via disulfide bridges, which makes it irreversibly adsorbed with respect to dilution. The amount of released silver is further influenced by the structure of the LSZ layer. At low LSZ concentrations (≤0.1 g/L) the amount of released silver is not significantly different compared with non-protein-containing NaNO3 solutions; however, noticeable reduction was observed at higher concentrations (1 g/L). This reduction in silver release has several possible explanations, including (i) surface complexation between LSZ and silver ions that may result in the incorporation of silver in the irreversible adsorbed layer and, hence, reduce the amount of released silver into solution, and (ii) net charge reversal at the protein/solution interface to slightly positive surface potentials. Any release of silver will therefore exhibit an electrostatic repulsion during transportation through the protein layer results in a reduced amount of silver in solution.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adsorption of Lysozyme on Silver and Its Influence on Silver Release

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In fact, silver in the form of salts, metal films, and NPs have been the dominant component of antibacterial technology over the last two decades [ 30 , 37 ]. Numerous research reports have explored the synthesis of AgNPs by various means [ 117 , 118 , 119 ], the preparation of hybrid AgNP containing materials [ 118 , 120 , 121 , 122 ], as well as the applications of Ag nanomaterials in developing antibacterial coatings [ 123 , 124 , 125 , 126 , 127 , 128 ].…”

Section: Immune Response Of Silver-coated Implantsmentioning

confidence: 99%

The Impact of Engineered Silver Nanomaterials on the Immune System

2020

Self Cite

View full text Add to dashboard Cite

Over the last decades there has been a tremendous volume of research efforts focused on engineering silver-based (nano)materials. The interest in silver has been mostly driven by the element capacity to kill pathogenic bacteria. In this context, the main area of application has been medical devices that are at significant risk of becoming colonized by bacteria and subsequently infected. However, silver nanomaterials have been incorporated in a number of other commercial products which may or may not benefit from antibacterial protection. The rapid expansion of such products raises important questions about a possible adverse influence on human health. This review focuses on examining currently available literature and summarizing the current state of knowledge of the impact of silver (nano)materials on the immune system. The review also looks at various surface modification strategies used to generate silver-based nanomaterials and the immunomodulatory potential of these materials. It also highlights the immune response triggered by various silver-coated implantable devices and provides guidance and perspective towards engineering silver nanomaterials for modulating immunological consequences.

show abstract

“…These two strategies are often used in combination to maximize their impact. 8 However, the continued rise of antibiotic-resistant bacteria and concerns over silver nanoparticle toxicity 9 necessitate developing alternative strategies for biofilm disruption.…”

Section: ■ Introductionmentioning

confidence: 99%

Synthesis of Siliconized Photosensitizers for Use in ¹O₂-Generating Silicone Elastomers: An Electron Paramagnetic Resonance Study

et al. 2021

View full text Add to dashboard Cite

Biomedical devices based on silicone are essential tools in modern healthcare but can be compromised by the development of device-acquired infections (DAIs). Unfortunately, the continued rise of antibiotic-resistant organisms makes current strategies to combat DAIs insufficient. Recently, the use of photoactive coatings that produce reactive oxygen species, specifically singlet oxygen (1O2), has attracted attention as a potential alternative to traditional strategies to prevent DAIs. However, the synthesis and characterization of silicone devices capable of 1O2 production are not trivial. Development is hindered by the incompatibility of photosensitizers with the silicone matrix and an incomplete understanding of how the method of incorporation impacts 1O2 production. Using the Piers–Rubinsztajn reaction, the photosensitizer 5,10,15,20-(tetra-3-methoxyphenyl)porphyrin (TPMP) was derivatized to be compatible with silicone matrices without the assistance of solvents and could be incorporated either covalently or physically within silicone elastomers. Electron paramagnetic resonance measurements indicated that 1O2 was more efficiently generated from elastomers containing a covalently cross-linked TPMP derivative than their physically dispersed counterparts, due to the minimization of aggregates.

show abstract

Silver Containing Biomaterials

Cited by 7 publications

References 98 publications

Adsorption of Lysozyme on Silver and Its Influence on Silver Release

Adsorption of Lysozyme on Silver and Its Influence on Silver Release

The Impact of Engineered Silver Nanomaterials on the Immune System

Synthesis of Siliconized Photosensitizers for Use in ¹O₂-Generating Silicone Elastomers: An Electron Paramagnetic Resonance Study

Contact Info

Product

Resources

About

Silver Containing Biomaterials

Cited by 7 publications

References 98 publications

Adsorption of Lysozyme on Silver and Its Influence on Silver Release

Adsorption of Lysozyme on Silver and Its Influence on Silver Release

The Impact of Engineered Silver Nanomaterials on the Immune System

Synthesis of Siliconized Photosensitizers for Use in 1O2-Generating Silicone Elastomers: An Electron Paramagnetic Resonance Study

Contact Info

Product

Resources

About

Synthesis of Siliconized Photosensitizers for Use in ¹O₂-Generating Silicone Elastomers: An Electron Paramagnetic Resonance Study