Silver Decahedral Nanoparticles-Enhanced Fluorescence Resonance Energy Transfer Sensor for Specific Cell Imaging

Li, Hui; Hu, Hongting; Xu, Danke

doi:10.1021/ac5045274

Cited by 41 publications

(19 citation statements)

References 36 publications

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“…These results reflect the established ability of Sgc8 aptamer to target leukemia cells [20]. Sgc8 recognizes PTK-7 on the surface of CEM cells [18], recruiting nanoparticles to the surface and thereby making their uptake more efficient [23]. Our results suggest that Sgc8-MSN/Dox may target PTK-7-expressing cancer cells at primary as well as secondary sites or in circulation, making it useful for controlling metastasis.…”

Section: Dox Release From Sgc8-msn/dox In Vitrosupporting

confidence: 71%

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

et al. 2019

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How to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery system (Sgc8-MSN/Dox) based on aptamer-modified mesoporous silica nanoparticles that relies on the tumor-targeting ability of the aptamer Sgc8 to deliver doxorubicin (Dox) to leukemia cells in a targeted way, thereby improving therapeutic efficacy and reducing toxicity. In this work, Sgc8-MSN/Dox showed sustained Dox release, and they targeted and efficiently killed CCRF-CEM human acute T lymphocyte leukemia cells, suggesting potential as a cancer therapy.

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Section: Dox Release From Sgc8-msn/dox In Vitrosupporting

confidence: 71%

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

et al. 2019

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“…On the other hand, the signal enhancement associated with the use of nanomaterial-biomolecue assemblies provides the basis for ultrasensitive detection of analyte targets [7][8][9]. Among the different kinds of nanomaterials, noble metal based nanomaterials, such metal nanoparticles, metal nanorod and metal nanowire have attracted significant research interest due to the unique optical and electrical properties [10,11]. For example, studies have proved metal nanomaterials could promote electron transfer and then enhance the catalytic activity of enzymes [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical detection of carcinoembryonic antigen based on silver nanocluster/horseradish peroxidase nanocomposite as signal probe

Zuo

et al. 2015

Electrochimica Acta

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“…Incorporating an ATP aptamer to trigger ATP‐responsive structure transformation of ASNCB, ATP binding event induced ASNCB conformational transition and increased fluorescent signal of silver nanoclusters. Besides NCs, other silver nanomaterials, such as silver nanoparticles and silver decahedral nanoparticles, possess interesting properties, such as metal‐enhanced fluorescence that increases the emission intensity of fluorophores nearby. Taking advantage of this feature, Li et al (Figure D) developed a multifunctional theranostic agent based on the aptamer−silver conjugation and applied it for cancer therapy and fluorescence‐enhanced cell imaging .…”

Section: Molecular Engineering Of Aptamer‐based Nanomaterials Toward mentioning

confidence: 99%

Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications

Zhang

Lan

2019

Adv Healthcare Materials

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equally exciting and perhaps more challenging field of application is toward their in vivo applications, including living animals and human bodies, in diverse areas, [2] such as sensing, drug delivery, medical imaging, and cancer therapy. However, most of these nanomaterials lack selectivity toward targets of interests. Therefore, to employ these nanomaterials for a wider range of in vivo applications, various molecular engineering approaches have been employed to obtained nanomaterials functionalized with biomolecules to enable selective targeting. [3][4][5] Among these biomolecules, functional nucleic acids, or FNAs, have shown the most promise.FNAs are DNA or RNA molecules that can interact with or bind to a specific analyte, resulting in a conformational change and/or a catalytic reaction. [6] As their names suggested, ribozymes and deoxyribozymes (called DNAzyme hereafter) can act as enzymes in the presence of cofactors to catalyze various reactions, including cleavage and ligation of RNA/DNA, and phosphorylation and peroxidation of DNA. On the other hand, riboswitches and DNA aptamers are antibody-like receptors that can bind target molecules with high affinity and selectivity. Furthermore, the binding abilities of riboswitches and aptamers can be combined with the enzymatic function of ribozymes or DNAzymes to form aptazymes so that the binding of targets can inhibit or enhance the catalytic activities. These nucleic acids, including DNAzymes, aptamers, and aptazymes, are collectively known as FNAs to emphasize their functions beyond the traditional genetic storage and transformations roles for DNA and RNA. Unlike DNA and RNA inside biological systems, FNAs are isolated via a combinatorial technique known as in vitro selection, or a process also known as systematic evolution of ligands by exponential enrichment (SELEX). The discovery of new functions of nucleic acids has not only resulted in major advances in the fields of molecular biology and biochemistry, but also revolutionized sensors designs for both in vitro and in vivo applications. [7,8] Over the past decade, numerous FNA-based nanomaterials have been developed. [9][10][11][12] Among these FNA-based nanosystems, the functions of FNAs can be categorized into two types: diagnostic function and therapeutic function. For the diagnostic function, the FNAs serve either as the biorecognition ligands for direct sensing and imaging of the Recent advances in nanotechnology and engineering have generated many nanomaterials with unique physical and chemical properties. Over the past decade, numerous nanomaterials are introduced into many research areas, such as sensors for environmental monitoring, food safety, point-ofcare diagnostics, and as transducers for solar energy transfer. Meanwhile, functional nucleic acids (FNAs), including nucleic acid enzymes, aptamers, and aptazymes, have attracted major attention from the biomedical community due to their unique target recognition and catalytic properties. Benefiting from the recent progress of molecular engine...

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Silver Decahedral Nanoparticles-Enhanced Fluorescence Resonance Energy Transfer Sensor for Specific Cell Imaging

Cited by 41 publications

References 36 publications

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

Electrochemical detection of carcinoembryonic antigen based on silver nanocluster/horseradish peroxidase nanocomposite as signal probe

Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications

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