Silver-dendrimer nanocomposite as emerging therapeutics in anti-bacteria and beyond

Fu, Xiaoling; Rehman, Urushi; Wei, Liuya; Chen, Zhe‐Sheng; Abourehab, Mohammed A.S.; Kesharwani, Prashant; Chen, Zhihong

doi:10.1016/j.drup.2023.100935

Cited by 21 publications

(7 citation statements)

References 97 publications

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“…112 Silver nanoparticles (AgNPs) have attracted attention for their antimicrobial properties and ability to inhibit angiogenesis, making them an intriguing alternative to AuNPs. 113 Studies have demonstrated that AgNPs in the size range of 15-50 nm exhibit a powerful antioxidant effect, which could potentially be utilized to prevent the development of cataracts. The experimental results demonstrated that AgNPs exhibited concentration-dependent antioxidant activity and potent anti-cataract effects in the selenium cataractogenesis animal model.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Chen,

Ye,

Chen

et al. 2024

IJN

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Cataract is a leading cause of blindness globally, and its surgical treatment poses a significant burden on global healthcare. Pharmacologic therapies, including antioxidants and protein aggregation reversal agents, have attracted great attention in the treatment of cataracts in recent years. Due to the anatomical and physiological barriers of the eye, the effectiveness of traditional eye drops for delivering drugs topically to the lens is hindered. The advancements in nanomedicine present novel and promising strategies for addressing challenges in drug delivery to the lens, including the development of nanoparticle formulations that can improve drug penetration into the anterior segment and enable sustained release of medications. This review introduces various cutting-edge drug delivery systems for cataract treatment, highlighting their physicochemical properties and surface engineering for optimal design, thus providing impetus for further innovative research and potential clinical applications of anti-cataract drugs.

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Section: Metal Nanoparticlesmentioning

confidence: 99%

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Chen,

Ye,

Chen

et al. 2024

IJN

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“…Slow, sustained release of silver ions then disrupts mitochondria, inhibiting ATP production and causing DNA damage, enzyme inactivation, and ROS generation, affecting cellular components. These collective actions contribute to the antimicrobial efficacy of AgNPs@AL, ultimately resulting in bacterial demise [51]. To further elucidate the mechanism underlying AgNPs@AL-induced bacterial eradication, scanning electron microscopy (SEM) was employed to examine bacterial morphological changes.…”

Section: Antibacterial Mechanism Of Agnps@almentioning

confidence: 99%

Solvent-Induced Lignin Conformation Changes Affect Synthesis and Antibacterial Performance of Silver Nanoparticle

Li,

Chen

2024

Nanomaterials

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The emergence of antibiotic-resistant bacteria necessitates the development of novel, sustainable, and biocompatible antibacterial agents. This study addresses cytotoxicity and environmental concerns associated with traditional silver nanoparticles (AgNPs) by exploring lignin, a readily available and renewable biopolymer, as a platform for AgNPs. We present a novel one-pot synthesis method for lignin-based AgNPs (AgNPs@AL) nanocomposites, achieving rapid synthesis within 5 min. This method utilizes various organic solvents, demonstrating remarkable adaptability to a wide range of lignin-dissolving systems. Characterization reveals uniform AgNP size distribution and morphology influenced by the chosen solvent. This adaptability suggests the potential for incorporating lignin-loaded antibacterial drugs alongside AgNPs, enabling combined therapy in a single nanocomposite. Antibacterial assays demonstrate exceptional efficacy against both Gram-negative and Gram-positive bacteria, with gamma-valerolactone (GVL)-assisted synthesized AgNPs exhibiting the most potent effect. Mechanistic studies suggest a combination of factors contributes to the antibacterial activity, including direct membrane damage caused by AgNPs and sustained silver ion release, ultimately leading to bacterial cell death. This work presents a straightforward, adaptable, and rapid approach for synthesizing biocompatible AgNPs@AL nanocomposites with outstanding antibacterial activity. These findings offer a promising and sustainable alternative to traditional antibiotics, contributing to the fight against antibiotic resistance while minimizing environmental impact.

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“…From the standpoint of research and development, nanoparticulate agents used in cancer imaging can be split into two groups: those that target blood vessels and those that selectively target cancerous cells. In regards, a variety of nanoparticle-based targeted agents have been created for use with various detection methods [ 19 – 24 , 29 , 30 , 37 , 43 – 45 ] (Table 1 ).…”

Section: Nanoparticle-based Cancer Imagingmentioning

confidence: 99%

New opportunities for RGD-engineered metal nanoparticles in cancer

et al. 2023

Self Cite

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The advent of nanotechnology has opened new possibilities for bioimaging. Metal nanoparticles (such as gold, silver, iron, copper, etc.) hold tremendous potential and offer enormous opportunities for imaging and diagnostics due to their broad optical characteristics, ease of manufacturing technique, and simple surface modification. The arginine-glycine-aspartate (RGD) peptide is a three-amino acid sequence that seems to have a considerably greater ability to adhere to integrin adhesion molecules that exclusively express on tumour cells. RGD peptides act as the efficient tailoring ligand with a variety of benefits including non-toxicity, greater precision, rapid clearance, etc. This review focuses on the possibility of non-invasive cancer imaging using metal nanoparticles with RGD assistance. Graphical abstract

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Silver-dendrimer nanocomposite as emerging therapeutics in anti-bacteria and beyond

Cited by 21 publications

References 97 publications

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Solvent-Induced Lignin Conformation Changes Affect Synthesis and Antibacterial Performance of Silver Nanoparticle

New opportunities for RGD-engineered metal nanoparticles in cancer

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