Silver-doped calcium phosphate nanopowders prepared by electrostatic spraying

Hwang, Kyu–Seog; Hwangbo, Seung; Kim, Jin‐Tae

doi:10.1007/s11051-008-9404-1

Cited by 36 publications

(19 citation statements)

References 5 publications

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“…The ion-exchange process can occur through various methods such as the nucleation of HA (co-precipitation), 15 electrostatic spraying 16 and microwave processing processes. The ion-exchange process can occur through various methods such as the nucleation of HA (co-precipitation), 15 electrostatic spraying 16 and microwave processing processes.…”

Section: Introductionmentioning

confidence: 99%

“…Based on the ion-exchange ability of the apatite structure, Ag þ ions are adsorbed from the solution and incorporated into the Ca site of HA. The ion-exchange process can occur through various methods such as the nucleation of HA (co-precipitation), 15 electrostatic spraying 16 and microwave processing processes. 17 As the natural bone mineral is mainly made up of apatite, obtaining phase-pure silversubstituted hydroxyapatite (AgHA) is desired for favorable cell interaction.…”

Section: Introductionmentioning

confidence: 99%

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Effect of silver content on the antibacterial and bioactive properties of silver‐substituted hydroxyapatite

Lim

Teo

et al. 2013

J Biomedical Materials Res

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The long-term success of a biomaterial used during surgery may be compromised by infection. A possible effective solution is to make the biomaterial osteoconductive and antibacterial. A range of silver-substituted hydroxyapatite (AgHA) of up to 1.1 wt. % of Ag was synthesized. AgHA displayed a rod-like morphology of dimensions ~50 nm in length and ~15 nm in width. Phase-pure AgHA was demonstrated in the X-ray diffraction patterns and Fourier transform infrared spectroscopy spectra. Comparing with hydroxyaptite (HA), 0.5AgHA exhibited a 3-log reduction in the number of bacteria. Diffusion of the entrapped Ag(+) ions towards the crystal structure surface was revealed by an increase of 6 at. % Ag in the X-ray photoelectron spectroscopy results. Furthermore, less than 0.5 ppm of Ag(+) ions being released from 0.5AgHA into the deionized water medium was evidenced from the inductively coupled plasma mass spectrometry results. AgHA produced by co-precipitation gave rise to minimal release of Ag(+) ions. It was hypothesized that the diffused surface Ag(+) ions damaged the bacteria cell membrane and impede its replication. With the culturing time, significant increase in the number of human mesenchymal stem cells (p < 0.05) was demonstrated on 0.5AgHA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of silver content on the antibacterial and bioactive properties of silver‐substituted hydroxyapatite

Lim

Teo

et al. 2013

J Biomedical Materials Res

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“…To narrow the subject of the review, with a few important exceptions, undoped and un-substituted calcium orthophosphates are considered and discussed only. The readers interested in various nanodimensional and nanocrystalline ion-substituted calcium orthophosphates [25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51], calcium orthophosphate-based nanocomposites [52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70] or nanodimensional calcium orthophosphate-based composites [71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86] are advised to read the original papers. Furthermore, addi...…”

Section: Introductionmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Dorozhkin¹

2009

Materials

246

150

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Recent developments in biomineralization have already demonstrated that nanosized particles play an important role in the formation of hard tissues of animals. Namely, the basic inorganic building blocks of bones and teeth of mammals are nanodimensional and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds nanocrystals of a biological apatite were found to be combined into self-assembled structures under the control of various bioorganic matrixes. In addition, the structures of both dental enamel and bones could be mimicked by an oriented aggregation of nanosized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nanodimensional and nanocrystalline calcium orthophosphates for a clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various types of cells were detected on smaller crystals of calcium orthophosphates. Thus, the nanodimensional and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the field of hard tissue engineering starting from bone repair and augmentation to the controlled drug delivery devices. This paper reviews current state of knowledge and recent developments of this subject starting from the synthesis and characterization to biomedical and clinical applications. More to the point, this review provides possible directions of future research and development.

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“…It is known that the insertion of CO 3 2-into the B-type sites of HA can decrease the (h k 0) distances and increase the (0 0 l) distances. The opposite behavior is observed when CO 3 2-ions are placed in the A-type sites 20,26,27 . However, these distortions are much more remarkable when CO 3 2-is confined in the hydroxyl channels of HA, which may explain the behavior observed in this work.…”

Section: Structural Changesmentioning

confidence: 92%

Crystallographic Aspects Regarding the Insertion of Ag+ Ions into a Hydroxyapatite Structure

et al. 2015

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Silver-doped calcium phosphate nanopowders prepared by electrostatic spraying

Cited by 36 publications

References 5 publications

Effect of silver content on the antibacterial and bioactive properties of silver‐substituted hydroxyapatite

Effect of silver content on the antibacterial and bioactive properties of silver‐substituted hydroxyapatite

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Crystallographic Aspects Regarding the Insertion of Ag+ Ions into a Hydroxyapatite Structure

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