Silver molybdate nanoparticles based immunosensor for the non-invasive detection of Interleukin-8 biomarker

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

“…Hence, interleukin (IL) is a term that describes this group of cytokines that are capable of being signaling cells. Of the various IL species, in this section the focus will be on IL-6 and IL-8, which are important biomarkers for colorectal and oral cancers, respectively [ 282 , 284 ]. IL-6 contains 184 amino acids that iss about 26 kDa in MW [ 284 ].…”

“…Of the various IL species, in this section the focus will be on IL-6 and IL-8, which are important biomarkers for colorectal and oral cancers, respectively [ 282 , 284 ]. IL-6 contains 184 amino acids that iss about 26 kDa in MW [ 284 ]. This glycoprotein is responsible for signaling cancer cells, and overexpression is related to colorectal cancer [ 282 ].…”

“…This glycoprotein is responsible for signaling cancer cells, and overexpression is related to colorectal cancer [ 282 ]. On the other hand, the MW of IL-8 is about 8.5 kDa, with its 70 amino acids [ 284 ]. Enzyme-linked immunosorbent assay (ELISA) and a few other methods are commercially available for the detection of these biomarkers [ 285 , 290 ].…”

Fabrication of Electrochemical Immunosensor for Detection of Interleukin 8 Biomarker via Layer‐by‐layer Self‐assembly Process on Cost‐effective Fluorine Tin Oxide Electrode

“…These works clearly indicate that IL‐8 protein has an effect in cancer formation, and it can be used as a diagnostic biomarker [4]. The IL 8 protein levels in saliva are found as 250 pg/mL and 720 pg/mL in healthy human and patients with oral cancer, respectively [3,5]. The level of IL‐8 protein in human serum of a healthy person and patients with a head and neck cancer are <13 pg/mL and >20 pg/mL, respectively [1].…”

“…It contains two N-terminal cysteines separated by an amino acid [2]. Several researchers have displayed that obtained levels of IL-8 protein is related to metastatic potential of melanoma, breast, renal, gastric, ovarian, pancreatic, and colorectal cancers [2][3]. Additionally, the overexpression of IL 8 corresponds to disease progression of urogenital cancers such as bladder transitional cell and prostate cancer.…”