Silver nanoparticle-adjuvanted vaccine protects against lethal influenza infection through inducing BALT and IgA-mediated mucosal immunity

Sanchez-Guzman, Daniel; Guen, Pierre Le; Villeret, Bérengère; Sola, N Rudi; Borgne, Rémi Le; Guyard, Alice; Kemmel, Alix; Crestani, Bruno; Sallenave, Jean-Michel; García-Verdugo, Ignacio

doi:10.1016/j.biomaterials.2019.119308

Cited by 60 publications

(36 citation statements)

References 51 publications

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“…This vaccine which was made from inactivated S. aureus in combination with AgNO 3 , has been shown to be more effective than a vaccine with S. aureus alone and has led to an increase in T-cell and B-cell counts while raising the rate of phagocytes and antibodies in the mice blood serum. Also, the positive effects of such nanoparticles on the respiratory viruses have been demonstrated [39,40]. Furthermore, it has been shown that when nanoparticles are used as adjuvants in vaccine production, they lead to increased antigen presentation and stronger immunity than common adjuvants [40,41].…”

Section: Discussionmentioning

confidence: 99%

Green Synthesized Silver Nanoparticles Using Anise (Pimpinella anisum L.) have Antibacterial Effects

Rashnaei

Siadat

Sepahi

et al. 2020

vacres

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Silver nanoparticles are particles of silver with a size of 1 to 100 nm. These agents have various applications and particularly have received much attention for their antibacterial activity and their use in vaccine production. Among the various methods of synthesizing nanoparticles, using plants due to their high reducing capabilities and also their eco-friendliness is of interest. Methods: Silver nanoparticles (AgNPs) were synthesized using plant anise (Pimpinella anisum L.) and validated using UVspectrophotometer, transmission electron microscopy and Fourier transform infrared spectroscopy. The produced AgNPs were used against Escherichia coli, Salmonella typhimurium, Staphylococcus aureus and Enterococcus faecalis to examine their antibacterial activities via agar well diffusion, disk diffusion and minimum inhibitory concentration methods. Furthermore, AgNPs were used in combination with three antibiotic disks, namely, Ceftriaxone, Tetracycline and Gentamicin to seek any cooperative effect. Results: Antibacterial effects due to the synthesized AgNPs were observed toward E. coli, S. aureus, S. typhimurium in this order; however, E. faecalis showed the highest resistance to the synthesized AgNPs. Conclusion: AgNPs synthesized using anise had similar antibacterial effects as conventional antibiotics; however with potentially less side effects.

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Section: Discussionmentioning

confidence: 99%

Green Synthesized Silver Nanoparticles Using Anise (Pimpinella anisum L.) have Antibacterial Effects

Rashnaei

Siadat

Sepahi

et al. 2020

vacres

View full text Add to dashboard Cite

show abstract

“…In the process of vaccination, the utilizing of vaccine adjuvants and follow-up evaluations are very critical. For instance, silver NPs can be deployed as an adjuvant in mucosal vaccines based on inactivated influenza virus, which stimulates the remarkable antigen specific IgA formation with low toxicity by stimulating bronchus-associated lymphoid tissue (BALT) neogenesis [127]. Additionally, in one study, gold NPs and toll-like receptor agonists (applied as operative adjuvant in UV-inactivated SARS-CoV vaccine) were investigated as vaccine adjuvants for application with recombinant S protein [50].…”

Section: Covs and Nanovaccinesmentioning

confidence: 99%

Nanomaterials and Nanotechnology-Associated Innovations against Viral Infections with a Focus on Coronaviruses

et al. 2020

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Viral infections have recently emerged not only as a health threat to people but rapidly became the cause of universal fatality on a large scale. Nanomaterials comprising functionalized nanoparticles (NPs) and quantum dots and nanotechnology-associated innovative detection methods, vaccine design, and nanodrug production have shown immense promise for interfacing with pathogenic viruses and restricting their entrance into cells. These viruses have been scrutinized using rapid diagnostic detection and therapeutic interventional options against the caused infections including vaccine development for prevention and control. Coronaviruses, namely SARS-CoV, MERS-CoV, and SARS-CoV-2, have endangered human life, and the COVID-19 (caused by SARS-CoV-2) outbreak has become a perilous challenge to public health globally with huge accompanying morbidity rates. Thus, it is imperative to expedite the drug and vaccine development efforts that would help mitigate this pandemic. In this regard, smart and innovative nano-based technologies and approaches encompassing applications of green nanomedicine, bio-inspired methods, multifunctional bioengineered nanomaterials, and biomimetic drug delivery systems/carriers can help resolve the critical issues regarding detection, prevention, and treatment of viral infections. This perspective review expounds recent nanoscience advancements for the detection and treatment of viral infections with focus on coronaviruses and encompasses nano-based formulations and delivery platforms, nanovaccines, and promising methods for clinical diagnosis, especially regarding SARS-CoV-2.

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“…35 There are a number of exciting tissue-engineered human in vitro lung models currently available that could be leveraged for studying viral infection 36,37 and established in vivo models for respiratory viruses, including NHPs, already in use. [38][39][40] Elements that may improve the relevance of in vitro models include: (1) human rather than animal cell lines; (2) co-culture of multiple pulmonary cell lines; (3) 3D scaffolds that mimic native pulmonary architecture; and (4) culture methods that permit generation of ECM prior to viral inoculation. Additional head-to-head studies will need to be performed to determine if these components are necessary to capture the pathophysiology of viral infection.…”

Section: In Vitro Modelsmentioning

confidence: 99%

“…71 Silver nanoparticles have also been used to deliver inactivated influenza vaccine locally with some specificity to lung immune cells, resulting in greater IgG titers and reduced mortality in a murine model. 40 While there are currently fewer studies regarding coronavirus vaccines, there has been some success in mice in which nanoparticles were prepared from a SARS-CoV-1 peptide sequence, and subsequent sera was successful in preventing infection of Vero cells. 72 In addition to various particle-based platforms, tissue engineering strategies have been harnessed to create scaffold systems for vaccination enhancement.…”

Section: Vaccine Platformsmentioning

confidence: 99%

Role of Tissue Engineering in COVID-19 and Future Viral Outbreaks

Tatara

2020

Tissue Engineering Part A

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Silver nanoparticle-adjuvanted vaccine protects against lethal influenza infection through inducing BALT and IgA-mediated mucosal immunity

Cited by 60 publications

References 51 publications

Green Synthesized Silver Nanoparticles Using Anise (Pimpinella anisum L.) have Antibacterial Effects

Green Synthesized Silver Nanoparticles Using Anise (Pimpinella anisum L.) have Antibacterial Effects

Nanomaterials and Nanotechnology-Associated Innovations against Viral Infections with a Focus on Coronaviruses

Role of Tissue Engineering in COVID-19 and Future Viral Outbreaks

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